Protein: STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase (EC 4.3.1.17) (L-serine deaminase); L-threonine dehydratase (EC 4.3.1.19) (L-threonine deaminase)]

Gene: STDH, CHA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 101
UniProt ID: P25379

Gene Ontology (top 5):
GO:0003941 - L-serine ammonia-lyase activity
GO:0004794 - threonine deaminase activity
GO:0005739 - mitochondrion
GO:0006565 - L-serine catabolic process
GO:0006567 - L-threonine catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

368131

THDH
Threonine dehydratase, mitochondrial

1

20

High-throughput

0.618

High

673500

RCK1
Serine/threonine-protein kinase RCK1

2

3

Small-scale

0.543

High

673492

SPT7
SAGA complex subunit SPT7

1

2

High-throughput

0.536

High

673519

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

673510

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

4

High-throughput

0.500

High

673524

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

7

High-throughput

0.500

High

673477

XPO1
Exportin-1

1

2

High-throughput

0.489

High

673495

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

1

High-throughput

0.489

High

673527

GCN5
Histone acetyltransferase GCN5

1

1

High-throughput

0.489

High

673478

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.479

High

366943

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

456340

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.479

High

510235

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.479

High

514477

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

578920

HSC82
ATP-dependent molecular chaperone HSC82

1

11

High-throughput

0.479

High

594886

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

626608

HSP60
Heat shock protein 60, mitochondrial

1

3

High-throughput

0.479

High

635931

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

673474

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

673475

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.479

High

673487

PREP
Presequence protease, mitochondrial

1

1

High-throughput

0.479

High

673490

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.479

High

673493

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.479

High

673494

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.479

High

673501

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

673508

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

3

High-throughput

0.479

High

673512

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

673515

ALAT1
Alanine aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

673522

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

673532

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

13

High-throughput

0.479

High

361472

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.458

High

452634

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

484729

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

531445

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.458

High

604909

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

619327

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.458

High

642121

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

654582

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

673365

NFS1
Cysteine desulfurase, mitochondrial

1

0

High-throughput

0.458

High

673471

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

673472

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

0

High-throughput

0.458

High

673481

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.458

High

673482

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.458

High

673499

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.458

High

673503

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

673507

OXA1
Mitochondrial inner membrane protein OXA1

1

0

High-throughput

0.458

High

673509

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

673511

ETFB
Probable electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

673514

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.458

High

673518

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

673523

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.458

High

673525

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

673539

ETFD
Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.458

High

673542

ETFA
Probable electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

437884

KAPC
cAMP-dependent protein kinase type 3

1

2

High-throughput

0.457

High

470108

SPS1
Sporulation-specific protein 1

1

2

High-throughput

0.457

High

673473

RFA2
Replication factor A protein 2

1

2

High-throughput

0.457

High

673484

MKK2
MAP kinase kinase MKK2/SSP33

1

4

High-throughput

0.457

High

673489

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.457

High

673506

RV167
Reduced viability upon starvation protein 167

1

3

High-throughput

0.457

High

383535

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

392294

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.437

High

434856

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.437

High

435795

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

594215

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

Small-scale

0.437

High

673476

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

673479

HS104
Heat shock protein 104

1

7

High-throughput

0.437

High

673483

HOG1
Mitogen-activated protein kinase HOG1

1

4

High-throughput

0.437

High

673488

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

673496

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

673497

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.437

High

673505

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

673521

H3
Histone H3

1

1

High-throughput

0.437

High

673526

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

673528

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

673529

RUVB1
RuvB-like protein 1

1

7

High-throughput

0.437

High

673533

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.437

High

673537

MCA1
Metacaspase-1

1

1

High-throughput

0.437

High

673538

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

673541

RUVB2
RuvB-like protein 2

1

7

High-throughput

0.437

High

673485

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.407

High

673502

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.407

High

673504

YM11
Uncharacterized protein YMR124W

1

1

High-throughput

0.407

High

673517

SDA1
Protein SDA1

1

0

High-throughput

0.269

Low

449317

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

High-throughput

0.261

Low

575571

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

0

High-throughput

0.261

Low

660772

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

0

High-throughput

0.261

Low

673480

ARP2
Actin-related protein 2

1

0

High-throughput

0.261

Low

673486

RAD24
Checkpoint protein RAD24

1

0

High-throughput

0.261

Low

673491

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.261

Low

673498

LSM2
LSM complex subunit LSM2

1

0

High-throughput

0.261

Low

673513

LSM8
LSM2-LSM8 complex subunit LSM8

1

0

High-throughput

0.261

Low

673520

OCA2
Tyrosine-protein phosphatase-like protein OCA2

1

0

High-throughput

0.261

Low

673530

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.261

Low

673531

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.261

Low

673534

ASR1
Alcohol-sensitive RING finger protein 1

1

0

High-throughput

0.261

Low

673535

RBX1
RING-box protein HRT1

1

0

High-throughput

0.261

Low

673540

HRT3
F-box protein HRT3

1

0

High-throughput

0.261

Low

531617

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.249

Low

673516

CDH1
APC/C activator protein CDH1

1

0

Small-scale

0.249

Low

673536

SGO1
Shugoshin

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025