HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 15812817, 8665853, 8816440, 12896906, 30523157, 9130710, 25315821, 30898150, 25898135, 19060928, 15504738, 17148612, 21203579, 22733765, 25326665, 16843263, 19411071, 20227043, 21075308, 21278786 and 5 others

more...
Identification Methods affinity chromatography technology, pull down, two hybrid, protein complementation assay, beta galactosidase complementation, anti bait coimmunoprecipitation, cross-linking study, protein cross-linking with a bifunctional reagent
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Furin-like~Furin-like, Furin-like~GF_recep_IV, Furin-like~Recep_L_domain, GF_recep_IV~GF_recep_IV, GF_recep_IV~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain
Common GO terms GO:0004888 - transmembrane signaling receptor activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
and 16 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1255
Hs

1 1342
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024