Protein: PRS10
26S proteasome subunit RPT4 (26S protease subunit SUG2) (Proteasomal cap subunit)

Gene: PRS10, RPT4
Organism: Saccharomyces cerevisiae S288C
Interactions: 141
UniProt ID: P53549

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006289 - nucleotide-excision repair
GO:0008540 - proteasome regulatory particle, base subcomplex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850121

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

24

20

Small-scale

0.988

High

750742

PRS6A
26S proteasome regulatory subunit 6A

15

18

Small-scale

0.982

High

750982

PRS7
26S proteasome regulatory subunit 7 homolog

12

20

Small-scale

0.978

High

750875

PRS6B
26S proteasome regulatory subunit 6B homolog

10

19

Small-scale

0.973

High

803632

RPN1
26S proteasome regulatory subunit RPN1

10

20

Small-scale

0.972

High

921097

PRS8
26S proteasome regulatory subunit 8 homolog

8

19

Small-scale

0.970

High

826317

PSMD9
Probable 26S proteasome regulatory subunit p27

8

9

Small-scale

0.966

High

921115

RPN5
26S proteasome regulatory subunit RPN5

7

20

Small-scale

0.960

High

645193

PSB4
Proteasome subunit beta type-4

5

20

Small-scale

0.906

High

850327

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

17

High-throughput

0.896

High

744005

RAD23
UV excision repair protein RAD23

4

20

Small-scale

0.875

High

921105

RPN7
26S proteasome regulatory subunit RPN7

3

20

High-throughput

0.855

High

798567

HSM3
DNA mismatch repair protein HSM3

3

2

Small-scale

0.848

High

893067

PSD10
Probable 26S proteasome regulatory subunit p28

3

13

Small-scale

0.847

High

822420

PRS4
26S proteasome regulatory subunit 4 homolog

3

20

High-throughput

0.839

High

921112

RPN8
26S proteasome regulatory subunit RPN8

3

20

High-throughput

0.839

High

661548

PSA2
Proteasome subunit alpha type-2

3

20

High-throughput

0.827

High

636598

PSA7
Probable proteasome subunit alpha type-7

2

20

High-throughput

0.754

High

636678

PSA1
Proteasome subunit alpha type-1

2

20

High-throughput

0.754

High

727211

HS104
Heat shock protein 104

2

8

High-throughput

0.737

High

806780

RPN10
26S proteasome regulatory subunit RPN10

6

17

Small-scale

0.734

High

921117

RPN6
26S proteasome regulatory subunit RPN6

5

20

High-throughput

0.714

High

314897

SEM1
26S proteasome complex subunit SEM1

5

2

Small-scale

0.706

High

918100

RPN14
26S proteasome regulatory subunit RPN14

4

18

Small-scale

0.696

High

738331

RPN12
26S proteasome regulatory subunit RPN12

4

9

High-throughput

0.694

High

921094

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

12

High-throughput

0.691

High

921102

RPN9
26S proteasome regulatory subunit RPN9

4

18

High-throughput

0.691

High

740197

RPN2
26S proteasome regulatory subunit RPN2

4

20

High-throughput

0.683

High

408429

GAL4
Regulatory protein GAL4

3

2

Small-scale

0.674

High

803155

ECM29
Proteasome component ECM29

3

13

High-throughput

0.656

High

509663

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

777088

BDF1
Bromodomain-containing factor 1

1

8

High-throughput

0.621

High

616437

SEC18
Vesicular-fusion protein SEC18

1

20

High-throughput

0.618

High

661424

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.618

High

668402

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.618

High

679917

CDC48
Cell division control protein 48

1

20

High-throughput

0.618

High

721269

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.618

High

721323

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

735944

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.618

High

800854

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

821978

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

822009

PSA4
Proteasome subunit alpha type-4

1

20

High-throughput

0.618

High

921088

PRS10
26S proteasome subunit RPT4

1

19

High-throughput

0.618

High

150300

RPN13
26S proteasome regulatory subunit RPN13

2

3

High-throughput

0.611

High

817076

RPN3
26S proteasome regulatory subunit RPN3

2

17

High-throughput

0.601

High

670969

SIS1
Protein SIS1

2

12

High-throughput

0.584

High

454472

PHO4
Phosphate system positive regulatory protein PHO4

1

2

Small-scale

0.561

High

486497

TBA3
Tubulin alpha-3 chain

1

11

High-throughput

0.536

High

633496

PP11
Serine/threonine-protein phosphatase PP1-1

1

12

High-throughput

0.536

High

736122

ARP2
Actin-related protein 2

1

10

High-throughput

0.536

High

739991

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

7

Small-scale

0.536

High

796104

IMB2
Importin subunit beta-2

1

8

High-throughput

0.536

High

921098

ESC1
Silent chromatin protein ESC1

2

7

High-throughput

0.533

High

445358

CDC31
Cell division control protein 31

1

8

Small-scale

0.501

High

750196

UFD4
Ubiquitin fusion degradation protein 4

1

20

Small-scale

0.501

High

740085

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

2

High-throughput

0.494

High

921091

TMEDA
Endoplasmic reticulum vesicle protein 25

1

4

High-throughput

0.489

High

921103

UTP5
U3 small nucleolar RNA-associated protein 5

1

14

High-throughput

0.489

High

921111

SHS1
Seventh homolog of septin 1

1

10

High-throughput

0.489

High

794749

RTG3
Retrograde regulation protein 3

1

1

High-throughput

0.481

High

863934

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

5

High-throughput

0.481

High

921106

NKP2
Inner kinetochore subunit NKP2

1

1

High-throughput

0.481

High

364668

CDK1
Cyclin-dependent kinase 1

1

10

High-throughput

0.479

High

393104

HSP82
ATP-dependent molecular chaperone HSP82

1

15

High-throughput

0.479

High

435253

RS3
Small ribosomal subunit protein uS3

1

8

High-throughput

0.479

High

545739

SSB1
Ribosome-associated molecular chaperone SSB1

1

16

High-throughput

0.479

High

555267

RAD50
DNA repair protein RAD50

1

7

High-throughput

0.479

High

564786

ATN1
Sodium/potassium exporting P-type ATPase 1

1

13

High-throughput

0.479

High

579813

HSC82
ATP-dependent molecular chaperone HSC82

1

15

High-throughput

0.479

High

603089

EST1
Telomere elongation protein EST1

1

2

High-throughput

0.479

High

646482

RAD53
Serine/threonine-protein kinase RAD53

1

6

High-throughput

0.479

High

647175

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

5

High-throughput

0.479

High

682350

SPB4
ATP-dependent rRNA helicase SPB4

1

11

High-throughput

0.479

High

707772

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

735083

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

738889

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

739705

SPT16
FACT complex subunit SPT16

1

4

Small-scale

0.479

High

763952

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

779300

CENPA
Histone H3-like centromeric protein CSE4

1

8

High-throughput

0.479

High

792166

GBLP
Small ribosomal subunit protein RACK1

1

15

High-throughput

0.479

High

826705

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.479

High

864790

MPS3
Spindle pole body assembly component MPS3

1

3

High-throughput

0.479

High

877869

VATG
V-type proton ATPase subunit G

1

3

High-throughput

0.479

High

921089

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

11

High-throughput

0.479

High

921090

APJ1
J domain-containing protein APJ1

1

12

High-throughput

0.479

High

921092

SEN1
Helicase SEN1

1

2

High-throughput

0.479

High

921093

CDC14
Tyrosine-protein phosphatase CDC14

1

13

High-throughput

0.479

High

921099

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

3

High-throughput

0.479

High

921100

RUVB1
RuvB-like protein 1

1

9

High-throughput

0.479

High

921104

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.479

High

921107

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

921108

TFC6
Transcription factor tau 91 kDa subunit

1

3

High-throughput

0.479

High

921118

DBP10
ATP-dependent RNA helicase DBP10

1

14

High-throughput

0.479

High

921119

RUVB2
RuvB-like protein 2

1

9

High-throughput

0.479

High

921121

SMC6
Structural maintenance of chromosomes protein 6

1

4

High-throughput

0.479

High

921095

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.460

High

921109

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.460

High

921120

TMA17
Translation machinery-associated protein 17

1

0

High-throughput

0.460

High

921101

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

440960

CDC7
Cell division control protein 7

1

20

Small-scale

0.445

High

676215

MAS5
Mitochondrial protein import protein MAS5

1

12

High-throughput

0.445

High

737012

CDC3
Cell division control protein 3

1

8

High-throughput

0.439

High

809212

END3
Actin cytoskeleton-regulatory complex protein END3

1

9

High-throughput

0.439

High

817745

TSC11
Target of rapamycin complex 2 subunit TSC11

1

4

High-throughput

0.439

High

843252

KRI1
Protein KRI1

1

1

High-throughput

0.439

High

919516

AP18B
Clathrin coat assembly protein AP180B

1

3

High-throughput

0.439

High

921116

GYP5
GTPase-activating protein GYP5

1

3

High-throughput

0.439

High

383815

RS17A
Small ribosomal subunit protein eS17A

1

5

High-throughput

0.437

High

410252

RL25
Large ribosomal subunit protein uL23

1

5

High-throughput

0.437

High

433761

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.437

High

436080

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.437

High

442032

RS14A
Small ribosomal subunit protein uS11A

1

7

High-throughput

0.437

High

455180

RS19A
Small ribosomal subunit protein eS19A

1

6

High-throughput

0.437

High

503159

RS22A
Small ribosomal subunit protein uS8A

1

5

High-throughput

0.437

High

504333

RL31A
Large ribosomal subunit protein eL31A

1

4

High-throughput

0.437

High

514752

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.437

High

557620

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

9

Small-scale

0.437

High

558818

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

674745

RS2
Small ribosomal subunit protein uS5

1

7

High-throughput

0.437

High

677503

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

689575

RS7A
Small ribosomal subunit protein eS7A

1

7

High-throughput

0.437

High

753499

RS3A1
Small ribosomal subunit protein eS1A

1

7

High-throughput

0.437

High

778455

RS27A
Small ribosomal subunit protein eS27A

1

6

High-throughput

0.437

High

782658

PXL1
Paxillin-like protein 1

1

3

High-throughput

0.437

High

795470

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.437

High

802296

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

812521

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

815189

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

5

High-throughput

0.437

High

824758

MLP2
Protein MLP2

1

10

High-throughput

0.437

High

844555

UTP10
U3 small nucleolar RNA-associated protein 10

1

3

High-throughput

0.437

High

874440

RS12
Small ribosomal subunit protein eS12

1

5

High-throughput

0.437

High

921096

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

921110

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

921113

RS10A
Small ribosomal subunit protein eS10A

1

11

High-throughput

0.437

High

921114

ATG9
Autophagy-related protein 9

1

3

High-throughput

0.437

High

738679

EI2BB
Translation initiation factor eIF2B subunit beta

1

4

High-throughput

0.407

High

843214

SKP2
F-box protein SKP2

1

0

High-throughput

0.279

Low

600701

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.251

Low

796345

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

849699

FMP32
Protein FMP32, mitochondrial

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025