Protein: PRS8
26S proteasome regulatory subunit 8 homolog (Protein CIM3) (Protein SUG1) (Tat-binding protein TBY1)

Gene: PRS8, RPT6
Organism: Saccharomyces cerevisiae S288C
Interactions: 219
UniProt ID: Q01939

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006289 - nucleotide-excision repair
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850159

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

29

20

Small-scale

0.991

High

750994

PRS7
26S proteasome regulatory subunit 7 homolog

19

20

Small-scale

0.987

High

803658

RPN1
26S proteasome regulatory subunit RPN1

16

20

Small-scale

0.984

High

750885

PRS6B
26S proteasome regulatory subunit 6B homolog

12

19

Small-scale

0.979

High

744009

RAD23
UV excision repair protein RAD23

11

20

Small-scale

0.975

High

921097

PRS10
26S proteasome subunit RPT4

8

19

Small-scale

0.970

High

750756

PRS6A
26S proteasome regulatory subunit 6A

9

18

Small-scale

0.968

High

645200

PSB4
Proteasome subunit beta type-4

9

20

Small-scale

0.963

High

893071

PSD10
Probable 26S proteasome regulatory subunit p28

7

10

Small-scale

0.963

High

1033907

RPN5
26S proteasome regulatory subunit RPN5

7

20

Small-scale

0.962

High

798570

HSM3
DNA mismatch repair protein HSM3

7

2

Small-scale

0.956

High

1033891

RPN7
26S proteasome regulatory subunit RPN7

6

20

High-throughput

0.947

High

822426

PRS4
26S proteasome regulatory subunit 4 homolog

6

20

Small-scale

0.945

High

1033899

RPN8
26S proteasome regulatory subunit RPN8

6

20

Small-scale

0.938

High

826319

PSMD9
Probable 26S proteasome regulatory subunit p27

5

10

Small-scale

0.925

High

850335

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

15

Small-scale

0.925

High

1033874

PRS8
26S proteasome regulatory subunit 8 homolog

3

19

Small-scale

0.839

High

661431

PSA3
Proteasome subunit alpha type-3

3

20

Small-scale

0.827

High

661551

PSA2
Proteasome subunit alpha type-2

3

20

High-throughput

0.827

High

721271

PSB5
Proteasome subunit beta type-5

3

20

Small-scale

0.817

High

752627

HSP78
Heat shock protein 78, mitochondrial

2

6

High-throughput

0.793

High

509686

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

20

High-throughput

0.768

High

918103

RPN14
26S proteasome regulatory subunit RPN14

10

14

Small-scale

0.760

High

1033896

RIX7
Ribosome biogenesis ATPase RIX7

2

14

High-throughput

0.759

High

668404

PSB2
Proteasome subunit beta type-2

2

20

Small-scale

0.754

High

679984

CDC48
Cell division control protein 48

2

14

High-throughput

0.754

High

806801

RPN10
26S proteasome regulatory subunit RPN10

7

16

Small-scale

0.746

High

740209

RPN2
26S proteasome regulatory subunit RPN2

9

20

Small-scale

0.746

High

738333

RPN12
26S proteasome regulatory subunit RPN12

6

9

Small-scale

0.732

High

1033909

RPN6
26S proteasome regulatory subunit RPN6

6

20

High-throughput

0.732

High

1033882

RPN9
26S proteasome regulatory subunit RPN9

6

16

Small-scale

0.730

High

314902

SEM1
26S proteasome complex subunit SEM1

6

2

Small-scale

0.724

High

763006

SPT7
SAGA complex subunit SPT7

1

4

Small-scale

0.724

High

408432

GAL4
Regulatory protein GAL4

4

2

Small-scale

0.694

High

1033876

GCN5
Histone acetyltransferase GCN5

1

5

High-throughput

0.691

High

750203

UFD4
Ubiquitin fusion degradation protein 4

3

20

Small-scale

0.681

High

561511

TBP
TATA-box-binding protein

3

5

Small-scale

0.672

High

449359

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

3

1

High-throughput

0.667

High

150302

RPN13
26S proteasome regulatory subunit RPN13

3

2

Small-scale

0.662

High

803163

ECM29
Proteasome component ECM29

3

9

High-throughput

0.656

High

817082

RPN3
26S proteasome regulatory subunit RPN3

3

14

High-throughput

0.650

High

524883

HSP71
Heat shock protein SSA1

3

11

High-throughput

0.624

High

701733

URA7
CTP synthase 1

2

3

High-throughput

0.621

High

726240

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

2

1

Small-scale

0.621

High

636603

PSA7
Probable proteasome subunit alpha type-7

1

20

High-throughput

0.618

High

636682

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.618

High

662053

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.618

High

675258

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

721327

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

727256

HS104
Heat shock protein 104

1

4

High-throughput

0.618

High

735953

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.618

High

800857

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

821984

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

822014

PSA4
Proteasome subunit alpha type-4

1

20

High-throughput

0.618

High

873803

DSK2
Ubiquitin domain-containing protein DSK2

1

20

Small-scale

0.618

High

822969

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.613

High

1033912

RUVB2
RuvB-like protein 2

2

5

High-throughput

0.611

High

471428

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

1

High-throughput

0.601

High

671033

SIS1
Protein SIS1

2

7

High-throughput

0.601

High

917352

HUL5
E3 ubiquitin-protein ligase HUL5

2

19

High-throughput

0.601

High

1033901

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.586

High

440966

CDC7
Cell division control protein 7

2

20

Small-scale

0.584

High

625972

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

Small-scale

0.578

High

393193

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.571

High

454478

PHO4
Phosphate system positive regulatory protein PHO4

1

1

Small-scale

0.561

High

486509

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.536

High

545944

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.536

High

555272

RAD50
DNA repair protein RAD50

1

2

High-throughput

0.536

High

722179

XPO1
Exportin-1

1

3

High-throughput

0.536

High

739999

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

2

Small-scale

0.536

High

1025009

NUM1
Nuclear migration protein NUM1

2

2

High-throughput

0.535

High

1033878

ESC1
Silent chromatin protein ESC1

2

5

High-throughput

0.533

High

678994

NOT1
General negative regulator of transcription subunit 1

1

2

Small-scale

0.515

High

666529

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.513

High

761135

NOT4
General negative regulator of transcription subunit 4

1

0

Small-scale

0.512

High

445362

CDC31
Cell division control protein 31

1

4

Small-scale

0.501

High

656589

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.501

High

437950

KAPC
cAMP-dependent protein kinase type 3

1

8

High-throughput

0.500

High

470153

SPS1
Sporulation-specific protein 1

1

7

High-throughput

0.500

High

599062

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

3

High-throughput

0.500

High

647821

RFA1
Replication factor A protein 1

1

6

High-throughput

0.500

High

919640

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.500

High

924414

CBK1
Serine/threonine-protein kinase CBK1

1

6

High-throughput

0.500

High

1027258

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

7

High-throughput

0.500

High

1033886

KU80
ATP-dependent DNA helicase II subunit 2

1

1

High-throughput

0.500

High

920941

SOK2
Protein SOK2

1

0

High-throughput

0.493

High

923107

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.489

High

932619

TMEDA
Endoplasmic reticulum vesicle protein 25

1

1

High-throughput

0.489

High

548718

RNA1
Ran GTPase-activating protein 1

1

1

High-throughput

0.481

High

646075

KIN3
Serine/threonine-protein kinase KIN3

1

13

High-throughput

0.481

High

802526

SYSM
Serine--tRNA ligase, mitochondrial

1

4

High-throughput

0.481

High

829788

MAD1
Spindle assembly checkpoint component MAD1

1

3

High-throughput

0.481

High

636939

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.479

High

639570

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.479

High

651977

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.479

High

684080

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.479

High

1033905

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.479

High

435296

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.479

High

460741

CDC4
Cell division control protein 4

1

8

Small-scale

0.479

High

579917

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

597540

EF3A
Elongation factor 3A

1

3

High-throughput

0.479

High

647188

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

676668

SGF29
SAGA complex subunit SGF29

1

1

Small-scale

0.479

High

707937

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

735119

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

738902

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

748005

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

763974

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

779095

EF1G2
Elongation factor 1-gamma 2

1

2

High-throughput

0.479

High

779320

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.479

High

780000

POC2
Proteasome assembly chaperone 2

1

2

High-throughput

0.479

High

792196

GBLP
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.479

High

793973

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

8

Small-scale

0.479

High

797535

UMP1
Proteasome maturation factor UMP1

1

2

High-throughput

0.479

High

826756

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

849944

BLM10
Proteasome activator BLM10

1

7

High-throughput

0.479

High

864808

MPS3
Spindle pole body assembly component MPS3

1

2

High-throughput

0.479

High

877883

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.479

High

924456

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

9

High-throughput

0.479

High

924992

APJ1
J domain-containing protein APJ1

1

7

High-throughput

0.479

High

1033875

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

1033877

RPN4
Protein RPN4

1

2

Small-scale

0.479

High

1033879

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

1033880

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.479

High

1033881

CTK1
CTD kinase subunit alpha

1

8

Small-scale

0.479

High

1033884

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

1033893

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

1033894

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

1033902

CDC53
Cell division control protein 53

1

7

Small-scale

0.479

High

1033904

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

1033910

DBP10
ATP-dependent RNA helicase DBP10

1

6

High-throughput

0.479

High

755284

NUF2
Kinetochore protein NUF2

1

0

High-throughput

0.460

High

797903

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.460

High

817021

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

866057

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.460

High

1033892

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.460

High

402092

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

550073

RAP1
DNA-binding protein RAP1

1

0

Small-scale

0.458

High

739730

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.458

High

796175

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

849806

EPL1
Enhancer of polycomb-like protein 1

1

0

Small-scale

0.458

High

1033897

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1033913

MEX67
mRNA export factor MEX67

1

0

Small-scale

0.458

High

617414

GBB
Guanine nucleotide-binding protein subunit beta

1

10

High-throughput

0.457

High

737111

CDC11
Cell division control protein 11

1

3

High-throughput

0.457

High

797984

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.457

High

808541

TEM1
Protein TEM1

1

1

High-throughput

0.457

High

836086

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.457

High

364699

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.445

High

481731

HSP73
Heat shock protein SSA3

1

11

High-throughput

0.445

High

527461

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.445

High

597247

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.445

High

676275

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

740280

SMI1
Cell wall assembly regulator SMI1

1

1

High-throughput

0.445

High

742205

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.445

High

807259

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.445

High

811374

CAJ1
Protein CAJ1

1

8

High-throughput

0.445

High

819546

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

865043

TCPQ
T-complex protein 1 subunit theta

1

8

High-throughput

0.445

High

865635

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.445

High

924315

NOP13
Nucleolar protein 13

1

4

High-throughput

0.445

High

1033890

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

12

High-throughput

0.445

High

809221

END3
Actin cytoskeleton-regulatory complex protein END3

1

5

High-throughput

0.439

High

817752

TSC11
Target of rapamycin complex 2 subunit TSC11

1

2

High-throughput

0.439

High

1033885

VPS20
Vacuolar protein sorting-associated protein 20

1

1

High-throughput

0.439

High

383848

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

410290

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

436115

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

455214

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

503192

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504371

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

512140

RS4A
Small ribosomal subunit protein eS4A

1

2

Small-scale

0.437

High

512599

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.437

High

513165

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514783

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

557626

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

7

Small-scale

0.437

High

674782

RS2
Small ribosomal subunit protein uS5

1

6

High-throughput

0.437

High

677530

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

679056

FUB1
Silencing boundary-establishment protein FUB1

1

2

High-throughput

0.437

High

689611

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.437

High

734184

EF2
Elongation factor 2

1

2

High-throughput

0.437

High

747531

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

753534

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.437

High

778487

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

795497

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.437

High

802332

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

812579

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

816092

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

1

High-throughput

0.437

High

824769

MLP2
Protein MLP2

1

6

High-throughput

0.437

High

827585

RLP7
Ribosome biogenesis protein RLP7

1

5

High-throughput

0.437

High

844580

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

874475

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.437

High

918145

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

1

High-throughput

0.437

High

1033510

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

1033888

POC1
Proteasome chaperone 1

1

2

High-throughput

0.437

High

1033895

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

1033900

RS10A
Small ribosomal subunit protein eS10A

1

7

High-throughput

0.437

High

416827

DNLI1
DNA ligase 1

1

0

High-throughput

0.426

High

653891

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

672026

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.426

High

740429

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.426

High

763257

SQT1
Ribosome assembly protein SQT1

1

9

High-throughput

0.407

High

826475

DJP1
DnaJ-like protein 1

1

8

High-throughput

0.407

High

605922

HPR1
THO complex subunit HPR1

2

0

Small-scale

0.310

High

748192

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

Small-scale

0.282

High

1033906

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.269

Low

1033911

LAS17
Proline-rich protein LAS17

1

0

High-throughput

0.261

Low

550684

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.251

Low

743876

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.251

Low

1033889

ENT2
Epsin-2

1

0

High-throughput

0.251

Low

1033898

MPC54
Meiotic plaque component protein 54

1

0

High-throughput

0.251

Low

828312

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.249

Low

863975

YJQ3
Uncharacterized membrane protein YJL163C

1

0

High-throughput

0.249

Low

1033903

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

812204

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.232

Low

1033883

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.232

Low

1033887

SNO4
Probable glutathione-independent glyoxalase SNO4

1

0

High-throughput

0.232

Low

1033908

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025