HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PPAC (P24666)
Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)
Gene: ACP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 158
+	Hs
		337951 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		623729 EPHB1_HUMAN (644-1077): 3.21e-126: 415: 28.54		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		623719 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		623718 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		411300 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00