Protein: XRN1
5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)

Gene: XRN1
Organism: Homo sapiens
Interactions: 233
UniProt ID: Q8IZH2

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0000956 - nuclear-transcribed mRNA catabolic process
GO:0002151 - G-quadruplex RNA binding
GO:0003723 - RNA binding
GO:0004534 - 5'-3' RNA exonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1224383

RENT1
Regulator of nonsense transcripts 1

4

5

Small-scale

0.694

High

1158976

EDC4
Enhancer of mRNA-decapping protein 4

4

1

Small-scale

0.691

High

1224420

DCP1A
mRNA-decapping enzyme 1A

3

3

Small-scale

0.642

High

908018

RS16
Small ribosomal subunit protein uS9

2

2

High-throughput

0.628

High

1224403

RBM4
RNA-binding protein 4

2

5

High-throughput

0.628

High

803632

BAG6
Large proline-rich protein BAG6

2

2

High-throughput

0.625

High

347292

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.611

High

1224433

NAGK
N-acetyl-D-glucosamine kinase

2

0

High-throughput

0.602

High

1198356

PATL1
Protein PAT1 homolog 1

2

5

Small-scale

0.588

High

1224167

DCP1B
mRNA-decapping enzyme 1B

2

3

High-throughput

0.586

High

228020

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

553154

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

651655

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

High-throughput

0.584

High

1043941

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

3

High-throughput

0.584

High

1224431

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.584

High

644290

TTP
mRNA decay activator protein ZFP36

2

1

Small-scale

0.584

High

513431

FGF3
Fibroblast growth factor 3

2

1

High-throughput

0.574

High

875543

FGF8
Fibroblast growth factor 8

2

1

High-throughput

0.574

High

369972

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

71179

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

5

High-throughput

0.536

High

180372

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

269795

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

6

High-throughput

0.536

High

400991

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.536

High

470453

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

489148

H14
Histone H1.4

1

1

High-throughput

0.536

High

559822

H12
Histone H1.2

1

1

High-throughput

0.536

High

609954

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

5

High-throughput

0.536

High

614072

TBG1
Tubulin gamma-1 chain

1

1

High-throughput

0.536

High

642448

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.536

High

736578

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

773445

RL13A
Large ribosomal subunit protein uL13

1

3

High-throughput

0.536

High

842569

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.536

High

911183

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.536

High

916690

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.536

High

921901

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.536

High

922624

RL10A
Large ribosomal subunit protein uL1

1

5

High-throughput

0.536

High

923426

RL8
Large ribosomal subunit protein uL2

1

2

High-throughput

0.536

High

1028992

SRSF6
Serine/arginine-rich splicing factor 6

1

11

High-throughput

0.536

High

1170009

QSOX2
Sulfhydryl oxidase 2

1

1

High-throughput

0.536

High

1224379

PSPC1
Paraspeckle component 1

1

8

High-throughput

0.536

High

1224398

RBM4B
RNA-binding protein 4B

1

6

High-throughput

0.536

High

1224415

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.536

High

720889

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.533

High

271359

NPM3
Nucleoplasmin-3

1

0

High-throughput

0.513

High

451496

CLCA
Clathrin light chain A

1

0

High-throughput

0.513

High

851587

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

906875

PRS4
26S proteasome regulatory subunit 4

1

0

High-throughput

0.513

High

1169047

ZN574
Zinc finger protein 574

1

0

High-throughput

0.513

High

1224391

ZN668
Zinc finger protein 668

1

0

High-throughput

0.513

High

1224392

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1224401

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.513

High

1224434

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

1224444

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.513

High

1224452

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.513

High

453472

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

8

High-throughput

0.508

High

1031389

PABP4
Polyadenylate-binding protein 4

1

2

High-throughput

0.508

High

1059727

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

2

High-throughput

0.508

High

1224410

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.508

High

1072693

UBE3C
Ubiquitin-protein ligase E3C

1

3

High-throughput

0.489

High

276376

AP1G2
AP-1 complex subunit gamma-like 2

1

0

High-throughput

0.486

High

277088

STAM2
Signal transducing adapter molecule 2

1

0

High-throughput

0.486

High

334240

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.486

High

375973

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.486

High

821305

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.486

High

1191048

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.486

High

1224384

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

0

High-throughput

0.486

High

285166

DXO
Decapping and exoribonuclease protein

1

4

High-throughput

0.481

High

745223

RBMX
RNA-binding motif protein, X chromosome

1

2

High-throughput

0.481

High

786985

MTREX
Exosome RNA helicase MTR4

1

5

High-throughput

0.481

High

930918

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

High-throughput

0.481

High

966437

EXOSX
Exosome complex component 10

1

2

High-throughput

0.481

High

995396

LG3BP
Galectin-3-binding protein

1

1

High-throughput

0.481

High

1074478

SKI2
Superkiller complex protein 2

1

6

High-throughput

0.481

High

1130034

EXOS6
Exosome complex component MTR3

1

2

High-throughput

0.481

High

1224385

EXOS8
Exosome complex component RRP43

1

1

High-throughput

0.481

High

1224393

B3GT6
Beta-1,3-galactosyltransferase 6

1

1

High-throughput

0.481

High

1224402

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

2

High-throughput

0.481

High

1224414

PKHG2
Pleckstrin homology domain-containing family G member 2

1

2

High-throughput

0.481

High

1224443

SRRM2
Serine/arginine repetitive matrix protein 2

1

3

High-throughput

0.481

High

1224451

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

2

High-throughput

0.481

High

1224454

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.481

High

1224449

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

118884

GTPB1
GTP-binding protein 1

1

1

High-throughput

0.479

High

162975

XPO1
Exportin-1

1

1

High-throughput

0.479

High

232312

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

232930

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

241582

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

272633

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

301923

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

308877

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.479

High

322867

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

385148

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

569868

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

608041

FGFR4
Fibroblast growth factor receptor 4

1

2

High-throughput

0.479

High

668387

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

5

High-throughput

0.479

High

718006

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

742388

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

760167

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

779720

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

818237

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

820972

PRC2A
Protein PRRC2A

1

3

High-throughput

0.479

High

918512

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

966592

OTUD4
OTU domain-containing protein 4

1

1

High-throughput

0.479

High

968430

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

3

High-throughput

0.479

High

1025834

TADBP
TAR DNA-binding protein 43

1

5

High-throughput

0.479

High

1038523

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.479

High

1065004

R3HD1
R3H domain-containing protein 1

1

1

High-throughput

0.479

High

1066379

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1085813

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

1089527

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

6

High-throughput

0.479

High

1127645

PRC2B
Protein PRRC2B

1

3

High-throughput

0.479

High

1135874

TUT4
Terminal uridylyltransferase 4

1

2

High-throughput

0.479

High

1136166

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1162085

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1187663

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

1188544

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1200045

EST1A
Telomerase-binding protein EST1A

1

3

High-throughput

0.479

High

1219192

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

2

High-throughput

0.479

High

1222904

DI3L2
DIS3-like exonuclease 2

1

2

High-throughput

0.479

High

1224364

RHG18
Rho GTPase-activating protein 18

1

1

High-throughput

0.479

High

1224366

NIN
Ninein

1

1

High-throughput

0.479

High

1224371

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.479

High

1224375

PUM2
Pumilio homolog 2

1

1

High-throughput

0.479

High

1224378

PHIP
PH-interacting protein

1

4

High-throughput

0.479

High

1224381

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

1224382

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1224387

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.479

High

1224390

FUBP3
Far upstream element-binding protein 3

1

4

High-throughput

0.479

High

1224395

CEP89
Centrosomal protein of 89 kDa

1

1

High-throughput

0.479

High

1224397

ATX2
Ataxin-2

1

3

High-throughput

0.479

High

1224404

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

7

High-throughput

0.479

High

1224406

WWTR1
WW domain-containing transcription regulator protein 1

1

3

High-throughput

0.479

High

1224408

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1224409

RNF41
E3 ubiquitin-protein ligase NRDP1

1

1

Small-scale

0.479

High

1224411

YTDC2
3'-5' RNA helicase YTHDC2

1

5

High-throughput

0.479

High

1224416

RENT2
Regulator of nonsense transcripts 2

1

1

Small-scale

0.479

High

1224419

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

1

High-throughput

0.479

High

1224424

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

1224436

AGO2
Protein argonaute-2

1

1

High-throughput

0.479

High

1224437

AGO1
Protein argonaute-1

1

1

High-throughput

0.479

High

1224439

CC14A
Dual specificity protein phosphatase CDC14A

1

2

High-throughput

0.479

High

1224442

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

3

High-throughput

0.479

High

1224446

NINL
Ninein-like protein

1

1

High-throughput

0.479

High

1224447

R3HD2
R3H domain-containing protein 2

1

1

High-throughput

0.479

High

1224453

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.479

High

1224455

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

3

High-throughput

0.479

High

234129

FADS1
Acyl-CoA

1

0

High-throughput

0.460

High

323479

TM50A
Transmembrane protein 50A

1

0

High-throughput

0.460

High

453976

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

0

High-throughput

0.460

High

602121

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.460

High

656741

PSB5
Proteasome subunit beta type-5

1

0

High-throughput

0.460

High

800457

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.460

High

823062

AGRE5
Adhesion G protein-coupled receptor E5

1

0

High-throughput

0.460

High

823211

DPOD2
DNA polymerase delta subunit 2

1

0

High-throughput

0.460

High

1135490

RN187
E3 ubiquitin-protein ligase RNF187

1

0

High-throughput

0.460

High

1154535

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.460

High

1224377

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.460

High

1224425

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

1

0

High-throughput

0.460

High

1224426

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.460

High

1224448

EXOS1
Exosome complex component CSL4

1

0

High-throughput

0.460

High

61410

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

149678

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

164960

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.458

High

302557

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

328893

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

522051

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

776358

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.458

High

813599

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

982260

1433F
14-3-3 protein eta

1

0

High-throughput

0.458

High

1068802

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

1074365

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

1100882

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1127265

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.458

High

1145827

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

1148128

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1200487

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1205979

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

1218143

CEP97
Centrosomal protein of 97 kDa

1

0

High-throughput

0.458

High

1224372

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1224380

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

1224389

BICD1
Protein bicaudal D homolog 1

1

0

High-throughput

0.458

High

1224396

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.458

High

1224399

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1224407

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

1224412

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1224413

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1224417

CENPJ
Centromere protein J

1

0

High-throughput

0.458

High

1224421

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1224422

TLR9
Toll-like receptor 9

1

0

Small-scale

0.458

High

1224423

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1224429

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

0

High-throughput

0.458

High

1224435

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

1224440

CP131
Centrosomal protein of 131 kDa

1

0

High-throughput

0.458

High

1224441

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

1224445

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

1224450

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

87374

PATL2
Protein PAT1 homolog 2

1

4

Small-scale

0.445

High

167704

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

3

Small-scale

0.445

High

402234

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

1153285

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.445

High

1215858

DCP2
m7GpppN-mRNA hydrolase

1

2

Small-scale

0.445

High

431248

CATB
Cathepsin B

1

2

High-throughput

0.439

High

817323

LEPR
Leptin receptor

1

1

High-throughput

0.439

High

1170756

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1172671

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.437

High

1224368

CE120
Centrosomal protein of 120 kDa

1

1

High-throughput

0.437

High

1224369

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.437

High

1224370

POC1A
POC1 centriolar protein homolog A

1

2

High-throughput

0.437

High

1224376

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.437

High

1224386

PF21A
PHD finger protein 21A

1

3

High-throughput

0.437

High

1224430

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.437

High

1224438

HECD1
E3 ubiquitin-protein ligase HECTD1

1

5

High-throughput

0.437

High

1037289

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.426

High

1224394

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

873604

ADPRH
ADP-ribosylhydrolase ARH1

2

0

High-throughput

0.328

High

1224388

SCRN2
Secernin-2

2

0

High-throughput

0.318

High

1224365

VW5B2
von Willebrand factor A domain-containing protein 5B2

1

0

High-throughput

0.265

Low

1224374

SPT20
Spermatogenesis-associated protein 20

1

0

High-throughput

0.265

Low

1224428

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.265

Low

1224432

DPP2
Dipeptidyl peptidase 2

1

0

High-throughput

0.265

Low

116517

DNS2A
Deoxyribonuclease-2-alpha

1

0

High-throughput

0.251

Low

330330

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.251

Low

985797

AT5G2
ATP synthase F(0) complex subunit C2, mitochondrial

1

0

High-throughput

0.251

Low

1224373

ANGL6
Angiopoietin-related protein 6

1

0

High-throughput

0.251

Low

1224400

PADC1
Protease-associated domain-containing protein 1

1

0

High-throughput

0.251

Low

1224456

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.251

Low

230984

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.249

Low

855926

ZN131
Zinc finger protein 131

1

0

High-throughput

0.249

Low

1166839

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1224367

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

1224405

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.249

Low

1224418

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low

1224427

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024