HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: EPHA5 (P54756)
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Gene: EPHA5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	30898150
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Furin-like~fn3, EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1, Recep_L_domain~fn3
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1037
+	Hs
		383631 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA3_HUMAN (51-1037): 0: 1232: 66.53
+	Hs
		383712 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA4_HUMAN (33-1035): 0: 1223: 62.04
+	Hs
		383711 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB1_HUMAN (59-1034): 0: 1217: 55.98
+	Hs
		383632 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB2_HUMAN (60-1034): 0: 1209: 56.80
+	Hs
		383709 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB3_HUMAN (57-1037): 0: 1155: 54.13
+	Hs
		383630 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA2_HUMAN (58-1037): 0: 1105: 50.86
+	Hs
		383604 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA1_HUMAN (47-1028): 0: 995: 41.78
+	Hs
		171278 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB6_HUMAN (43-1023): 0: 944: 38.18
+	Hs
		383769 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MERTK_HUMAN (295-1003): 1.15e-151: 478: 21.77
+	Hs
		383541 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		IGF1R_HUMAN (294-1017): 7.97e-145: 469: 23.00
+	Hs
		383763 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TYRO3_HUMAN (293-975): 8.48e-147: 462: 21.19
+	Hs
		383608 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR3_HUMAN (404-988): 2.12e-147: 461: 21.80
+	Hs
		383752 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TIE2_HUMAN (357-949): 5.11e-141: 453: 26.79
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (653-933): 1.21e-65: 232: 42.76
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (659-933): 1.73e-65: 231: 43.68
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (669-933): 3.12e-64: 229: 44.20
+	Hs
		383527 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		INSR_HUMAN (372-515): 2.51e-11: 70.4: 17.09
+	Hs
		442833 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		HCK_HUMAN (653-933): 1.21e-65: 232: 42.76
+	Hs
		433770 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		LYN_HUMAN (659-933): 1.73e-65: 231: 43.68
+	Hs
		412202 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		FYN_HUMAN (669-933): 3.12e-64: 229: 44.20