HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: LMTK1 (Q6ZMQ8)
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
Gene: AATK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0016020 - membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1374
+	Hs
		383605 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR2_HUMAN (17-456): 6.43e-126: 412: 19.75
+	Hs
		383711 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB1_HUMAN (6-505): 2.12e-123: 410: 19.80
+	Hs
		383632 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB2_HUMAN (6-404): 5.81e-122: 408: 22.77
+	Hs
		383608 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR3_HUMAN (29-448): 5.82e-123: 403: 23.42
+	Hs
		383562 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR1_HUMAN (28-460): 6.26e-120: 396: 21.00
+	Hs
		383831 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK3_HUMAN (24-398): 5.5e-110: 369: 25.54
+	Hs
		383710 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA5_HUMAN (12-404): 9.44e-107: 365: 22.68
+	Hs
		383631 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA3_HUMAN (12-404): 1.11e-104: 358: 23.74
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (98-410): 1.51e-107: 352: 24.20
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (109-410): 9.62e-106: 347: 24.75
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (104-408): 1.36e-104: 344: 30.07
+	Hs
		383527 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		INSR_HUMAN (111-395): 4.12e-41: 167: 36.27
+	Hs
		383541 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		IGF1R_HUMAN (119-391): 2.65e-38: 159: 34.51
+	Hs
		383779 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTK7_HUMAN (32-391): 2.34e-37: 155: 31.90
+	Hs
		383575 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		INSRR_HUMAN (119-425): 6.94e-34: 144: 33.43
+	Hs
		383519 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK1_HUMAN (120-398): 5.02e-34: 143: 32.77
+	Hs
		383704 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BMX_HUMAN (119-391): 1.16e-32: 138: 32.12
+	Hs
		383672 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TXK_HUMAN (125-391): 2.9e-32: 135: 33.83
+	Hs
		383671 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TEC_HUMAN (119-412): 1.84e-31: 134: 30.07
+	Hs
		337300 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL1_HUMAN (588-1118): 4.91e-10: 66.4: 13.32