HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.845

The method score is based on:

Property Details
Experiments 22973453, 35384245, 16273093
Identification Methods pull down, affinity chromatography technology, unspecified method, protein array
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0005829 - cytosol
GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1255
Hs

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Last updated: 15 Jul 2024