Protein: STH1
Nuclear protein STH1/NPS1 (EC 3.6.4.12) (ATP-dependent helicase STH1) (Chromatin structure-remodeling complex protein STH1) (SNF2 homolog)

Gene: STH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 160
UniProt ID: P32597

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

743143

RSC2
Chromatin structure-remodeling complex subunit RSC2

23

19

Small-scale

0.989

High

743147

RSC58
Chromatin structure-remodeling complex protein RSC58

12

2

Small-scale

0.979

High

743123

RSC4
Chromatin structure-remodeling complex subunit RSC4

12

20

Small-scale

0.976

High

743139

ARP9
Actin-like protein ARP9

10

20

Small-scale

0.975

High

743155

ARP7
Actin-related protein 7

11

20

Small-scale

0.974

High

743114

RSC1
Chromatin structure-remodeling complex subunit RSC1

10

19

Small-scale

0.970

High

743121

H3
Histone H3

7

20

Small-scale

0.961

High

381968

H4
Histone H4

5

14

Small-scale

0.928

High

381025

H2B1
Histone H2B.1

4

20

Small-scale

0.903

High

419661

H2A2
Histone H2A.2

4

20

Small-scale

0.867

High

743097

ATAD2
ATPase histone chaperone YTA7

4

8

Small-scale

0.867

High

381455

H2B2
Histone H2B.2

3

20

High-throughput

0.830

High

401937

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

9

Small-scale

0.827

High

734400

BTAF1
TATA-binding protein-associated factor MOT1

2

16

Small-scale

0.789

High

743105

RSC8
Chromatin structure-remodeling complex protein RSC8

13

20

Small-scale

0.761

High

743115

RT102
Regulator of Ty1 transposition protein 102

11

2

Small-scale

0.757

High

743144

RSC3
Chromatin structure-remodeling complex protein RSC3

11

2

Small-scale

0.756

High

678306

RSC6
Chromatin structure-remodeling complex protein RSC6

11

20

Small-scale

0.756

High

402204

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

9

Small-scale

0.754

High

743067

RSC7
Chromatin structure-remodeling complex subunit RSC7

9

3

Small-scale

0.754

High

743141

SFH1
Chromatin structure-remodeling complex subunit SFH1

9

11

Small-scale

0.752

High

743126

RSC9
Chromatin structure-remodeling complex subunit RSC9

9

2

Small-scale

0.748

High

743159

HTL1
High temperature lethal protein 1

7

2

Small-scale

0.746

High

743079

CENPA
Histone H3-like centromeric protein CSE4

2

20

Small-scale

0.743

High

743075

TAF14
Transcription initiation factor TFIID subunit 14

6

2

Small-scale

0.740

High

743158

H2AZ
Histone H2A.Z

2

20

High-throughput

0.737

High

743127

GCN5
Histone acetyltransferase GCN5

2

20

High-throughput

0.712

High

743089

RSC30
Chromatin structure-remodeling complex protein RSC30

5

2

Small-scale

0.711

High

643620

SNF2
Transcription regulatory protein SNF2

1

18

High-throughput

0.691

High

743084

LDB7
Chromatin structure-remodeling complex protein RSC14

4

2

Small-scale

0.689

High

743153

SCC1
Sister chromatid cohesion protein 1

4

6

Small-scale

0.686

High

743094

SCC4
MAU2 chromatid cohesion factor homolog

3

4

Small-scale

0.664

High

743131

SCC2
Sister chromatid cohesion protein 2

3

3

Small-scale

0.664

High

523401

HSP71
Heat shock protein SSA1

3

18

High-throughput

0.633

High

534237

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

9

Small-scale

0.618

High

594266

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.618

High

647058

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.618

High

679502

CDC48
Cell division control protein 48

1

3

High-throughput

0.618

High

726865

HS104
Heat shock protein 104

1

4

High-throughput

0.618

High

743066

CHD1
Chromo domain-containing protein 1

1

16

High-throughput

0.618

High

743078

BDF1
Bromodomain-containing factor 1

1

20

High-throughput

0.618

High

743081

GBLP
Small ribosomal subunit protein RACK1

1

13

High-throughput

0.618

High

743082

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

17

High-throughput

0.618

High

743130

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.618

High

743145

BDF2
Bromodomain-containing factor 2

1

20

High-throughput

0.618

High

743156

RUVB2
RuvB-like protein 2

1

8

High-throughput

0.618

High

743142

PDP3
NuA3 HAT complex component PDP3

2

9

Small-scale

0.611

High

689771

INO2
Protein INO2

2

1

Small-scale

0.602

High

544218

SSB1
Ribosome-associated molecular chaperone SSB1

2

18

High-throughput

0.601

High

547777

NHP6A
Non-histone chromosomal protein 6A

2

20

Small-scale

0.601

High

547861

NHP6B
Non-histone chromosomal protein 6B

2

20

High-throughput

0.588

High

743111

RFX1
RFX-like DNA-binding protein RFX1

2

7

High-throughput

0.588

High

550040

RAP1
DNA-binding protein RAP1

2

2

Small-scale

0.585

High

743101

DSN1
Kinetochore-associated protein DSN1

2

4

High-throughput

0.584

High

736619

ASF1
Histone chaperone ASF1

1

11

High-throughput

0.575

High

743137

RCO1
Transcriptional regulatory protein RCO1

1

20

High-throughput

0.575

High

743140

SWR1
Helicase SWR1

1

15

High-throughput

0.575

High

743074

SAS3
Histone acetyltransferase SAS3

2

7

High-throughput

0.571

High

743076

SPT10
Protein SPT10

2

4

High-throughput

0.571

High

743119

APJ1
J domain-containing protein APJ1

2

9

High-throughput

0.571

High

743125

HOS3
Histone deacetylase HOS3

2

20

High-throughput

0.571

High

743136

POB3
FACT complex subunit POB3

2

8

High-throughput

0.571

High

638986

VPS1
Vacuolar protein sorting-associated protein 1

1

4

High-throughput

0.536

High

743154

HSP42
Heat shock protein 42

1

3

High-throughput

0.536

High

737807

HOG1
Mitogen-activated protein kinase HOG1

1

1

Small-scale

0.515

High

743085

TCM62
Mitochondrial chaperone TCM62

1

1

High-throughput

0.515

High

743103

RIM15
Serine/threonine-protein kinase RIM15

1

3

High-throughput

0.515

High

743083

NU170
Nucleoporin NUP170

1

0

Small-scale

0.513

High

408401

GAL4
Regulatory protein GAL4

1

4

Small-scale

0.501

High

473518

LEUR
Regulatory protein LEU3

1

4

Small-scale

0.501

High

743132

ARO80
Transcriptional activator ARO80

1

1

Small-scale

0.501

High

395231

GCN4
General control transcription factor GCN4

1

1

Small-scale

0.479

High

434942

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

448941

TOP2
DNA topoisomerase 2

1

7

High-throughput

0.479

High

561443

TBP
TATA-box-binding protein

1

3

High-throughput

0.479

High

569528

HAP4
Transcriptional activator HAP4

1

1

Small-scale

0.479

High

590579

HSP26
Heat shock protein 26

1

3

Small-scale

0.479

High

647730

RFA1
Replication factor A protein 1

1

8

Small-scale

0.479

High

706551

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

734896

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

739569

SPT16
FACT complex subunit SPT16

1

5

High-throughput

0.479

High

743068

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

10

High-throughput

0.479

High

743069

SMC1
Structural maintenance of chromosomes protein 1

1

6

Small-scale

0.479

High

743070

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

743077

SPT21
Protein SPT21

1

3

High-throughput

0.479

High

743087

LEO1
RNA polymerase-associated protein LEO1

1

3

Small-scale

0.479

High

743099

SCC3
Cohesin subunit SCC3

1

1

Small-scale

0.479

High

743108

SMC3
Structural maintenance of chromosomes protein 3

1

10

Small-scale

0.479

High

743112

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.479

High

743124

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

743133

IOC4
ISWI one complex protein 4

1

2

High-throughput

0.479

High

743135

DPB4
DNA polymerase epsilon subunit D

1

5

Small-scale

0.479

High

743148

MED7
Mediator of RNA polymerase II transcription subunit 7

1

1

Small-scale

0.479

High

743149

SGO1
Shugoshin

1

2

High-throughput

0.479

High

743150

ESA1
Histone acetyltransferase ESA1

1

7

Small-scale

0.479

High

743152

IOC2
ISWI one complex protein 2

1

2

High-throughput

0.479

High

737695

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

5

High-throughput

0.470

High

636444

IME1
Meiosis-inducing protein 1

1

0

Small-scale

0.458

High

735777

TFC1
Transcription factor tau 95 kDa subunit

1

0

High-throughput

0.458

High

743109

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

392440

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.445

High

448155

HAP2
Transcriptional activator HAP2

1

5

High-throughput

0.445

High

481547

HSP73
Heat shock protein SSA3

1

18

High-throughput

0.445

High

488934

SWI6
Regulatory protein SWI6

1

7

High-throughput

0.445

High

526216

HSP72
Heat shock protein SSA2

1

18

High-throughput

0.445

High

548760

MCM1
Pheromone receptor transcription factor

1

10

High-throughput

0.445

High

570795

ABF1
ARS-binding factor 1

1

1

High-throughput

0.445

High

645601

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

649935

SIN3
Transcriptional regulatory protein SIN3

1

15

High-throughput

0.445

High

653840

HSP12
12 kDa heat shock protein

1

1

High-throughput

0.445

High

671510

SWI4
Regulatory protein SWI4

1

7

High-throughput

0.445

High

675831

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.445

High

738731

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

1

High-throughput

0.445

High

741212

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

742802

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

743071

IXR1
Intrastrand cross-link recognition protein

1

20

High-throughput

0.445

High

743073

MSN2
Zinc finger protein MSN2

1

9

High-throughput

0.445

High

743080

SET3
SET domain-containing protein 3

1

14

High-throughput

0.445

High

743090

SSZ1
Ribosome-associated complex subunit SSZ1

1

13

High-throughput

0.445

High

743091

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

20

High-throughput

0.445

High

743092

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.445

High

743093

HSP7E
Heat shock protein SSC3, mitochondrial

1

12

High-throughput

0.445

High

743095

SSB2
Ribosome-associated molecular chaperone SSB2

1

18

High-throughput

0.445

High

743096

RT106
Histone chaperone RTT106

1

3

High-throughput

0.445

High

743106

TAF1
Transcription initiation factor TFIID subunit 1

1

4

High-throughput

0.445

High

743120

MOT3
Transcriptional activator/repressor MOT3

1

1

High-throughput

0.445

High

743129

GIS1
Transcriptional activator/repressor GIS1

1

9

High-throughput

0.445

High

743146

BRE1
E3 ubiquitin-protein ligase BRE1

1

13

High-throughput

0.445

High

743157

CAF1A
Chromatin assembly factor 1 subunit A

1

12

High-throughput

0.445

High

383592

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

410013

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

435857

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

441795

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

454949

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.437

High

502930

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.437

High

504114

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

512896

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514532

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.437

High

674499

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.437

High

743072

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.437

High

743088

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

743098

MAM33
Mitochondrial acidic protein MAM33

1

1

High-throughput

0.437

High

743110

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.437

High

743122

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

743151

RS10A
Small ribosomal subunit protein eS10A

1

5

High-throughput

0.437

High

743065

RTG1
Retrograde regulation protein 1

1

0

High-throughput

0.426

High

743102

AZF1
Transcription factor AZF1

1

0

High-throughput

0.426

High

743107

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

743113

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

743138

YM94
Uncharacterized protein YMR315W

1

0

High-throughput

0.426

High

394375

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.407

High

743100

DJP1
DnaJ-like protein 1

1

6

High-throughput

0.407

High

743116

JJJ1
J protein JJJ1

1

5

High-throughput

0.407

High

743134

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.407

High

743118

DMA2
E3 ubiquitin-protein ligase DMA2

1

0

High-throughput

0.279

Low

743128

NUP53
Nucleoporin NUP53

1

0

Small-scale

0.279

Low

740640

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.269

Low

743104

BUD27
Bud site selection protein 27

1

0

Small-scale

0.249

Low

743086

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.232

Low

743117

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025