HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SHD (Q96IW2)
SH2 domain-containing adapter protein D
Gene: SHD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 340
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (93-340): 1.58e-54: 188: 17.51
+	Hs
		208972 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NCK2_HUMAN (4-335): 5.61e-55: 185: 15.45
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (103-340): 1.42e-53: 185: 19.20
+	Hs
		383823 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHB_HUMAN (56-339): 2.52e-53: 184: 41.09
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (168-340): 2.04e-51: 180: 20.56
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (105-340): 1.54e-51: 180: 17.53
+	Hs
		383587 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NCK1_HUMAN (4-336): 5.26e-53: 180: 16.58
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (96-340): 1.01e-50: 178: 18.36
+	Hs
		383805 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB14_HUMAN (58-337): 3.58e-50: 177: 16.21
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (117-340): 5.02e-50: 175: 22.13
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (145-340): 4.99e-47: 168: 18.54
+	Hs
		383699 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BLK_HUMAN (126-340): 2.69e-46: 165: 19.20
+	Hs
		384022 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV3_HUMAN (122-339): 1.34e-44: 165: 17.60
+	Hs
		383740 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC2_HUMAN (49-340): 1.68e-43: 159: 19.67
+	Hs
		383905 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC3_HUMAN (110-338): 2.22e-43: 159: 22.22
+	Hs
		383673 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL2_HUMAN (152-337): 2.96e-41: 155: 26.18
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (181-338): 1.9e-44: 153: 22.01
+	Hs
		337300 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL1_HUMAN (152-339): 2.1e-39: 150: 24.23
+	Hs
		383794 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTK6_HUMAN (172-340): 8.92e-39: 144: 23.73
+	Hs
		275161 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRAP2_HUMAN (211-321): 5.36e-19: 88.3: 27.03