Protein: TSR1
Ribosome biogenesis protein TSR1 (20S rRNA accumulation protein 1)

Gene: TSR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 132
UniProt ID: Q07381

Gene Ontology (top 5):
GO:0000461 - endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000479 - endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

820401

RIO2
Serine/threonine-protein kinase RIO2

15

4

Small-scale

0.981

High

756697

LTV1
Protein LTV1

7

0

Small-scale

0.907

High

798326

ENP1
Essential nuclear protein 1

17

2

Small-scale

0.762

High

1059254

NOB1
20S-pre-rRNA D-site endonuclease NOB1

8

1

Small-scale

0.749

High

836205

DIM1
Dimethyladenosine transferase

8

1

Small-scale

0.747

High

1059261

RRP12
Ribosomal RNA-processing protein 12

6

2

Small-scale

0.732

High

1059266

PNO1
Pre-rRNA-processing protein PNO1

6

2

Small-scale

0.729

High

709474

HRR25
Casein kinase I homolog HRR25

5

4

Small-scale

0.718

High

918616

SLX9
Ribosome biogenesis protein SLX9

6

0

Small-scale

0.699

High

435639

RS9B
Small ribosomal subunit protein uS4B

3

4

High-throughput

0.662

High

436194

RS13
Small ribosomal subunit protein uS15

3

3

High-throughput

0.656

High

689688

RS7A
Small ribosomal subunit protein eS7A

3

3

High-throughput

0.656

High

512675

RS6A
Small ribosomal subunit protein eS6A

3

3

High-throughput

0.640

High

513245

RS8A
Small ribosomal subunit protein eS8A

3

2

Small-scale

0.640

High

525303

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.633

High

1059256

BMS1
Ribosome biogenesis protein BMS1

1

1

High-throughput

0.618

High

511861

RS24A
Small ribosomal subunit protein eS24A

2

2

High-throughput

0.611

High

655521

RS3A2
Small ribosomal subunit protein eS1B

2

5

High-throughput

0.611

High

688950

RS5
Small ribosomal subunit protein uS7

2

1

High-throughput

0.611

High

444633

DED1
ATP-dependent RNA helicase DED1

2

2

Small-scale

0.601

High

815437

RS26B
Small ribosomal subunit protein eS26B

2

1

High-throughput

0.601

High

383916

RS17A
Small ribosomal subunit protein eS17A

3

3

High-throughput

0.599

High

1059267

HRP1
Nuclear polyadenylated RNA-binding protein 4

2

1

High-throughput

0.588

High

149976

RS9A
Small ribosomal subunit protein uS4A

2

4

High-throughput

0.584

High

403670

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

1

High-throughput

0.584

High

435391

RS3
Small ribosomal subunit protein uS3

2

3

High-throughput

0.584

High

442132

RS14A
Small ribosomal subunit protein uS11A

2

4

High-throughput

0.584

High

512164

RS4A
Small ribosomal subunit protein eS4A

2

1

High-throughput

0.584

High

514857

RS18A
Small ribosomal subunit protein uS13A

2

2

High-throughput

0.584

High

570158

RL3
Large ribosomal subunit protein uL3

2

2

Small-scale

0.584

High

674858

RS2
Small ribosomal subunit protein uS5

2

3

High-throughput

0.584

High

747604

RSSA1
Small ribosomal subunit protein uS2A

2

6

High-throughput

0.584

High

753609

RS3A1
Small ribosomal subunit protein eS1A

2

5

High-throughput

0.584

High

792271

GBLP
Small ribosomal subunit protein RACK1

2

6

High-throughput

0.584

High

802412

RS20
Small ribosomal subunit protein uS10

2

2

High-throughput

0.584

High

874553

RS12
Small ribosomal subunit protein eS12

2

1

High-throughput

0.584

High

1033590

RS15
Small ribosomal subunit protein uS19

2

2

High-throughput

0.584

High

1059260

RIO1
Serine/threonine-protein kinase RIO1

2

4

High-throughput

0.584

High

455287

RS19A
Small ribosomal subunit protein eS19A

3

4

High-throughput

0.578

High

809425

STM1
Suppressor protein STM1

2

0

High-throughput

0.576

High

757847

PP2C3
Protein phosphatase 2C homolog 3

2

0

High-throughput

0.563

High

923065

TR112
Multifunctional methyltransferase subunit TRM112

2

0

Small-scale

0.559

High

503265

RS22A
Small ribosomal subunit protein uS8A

2

3

High-throughput

0.558

High

570313

RS17B
Small ribosomal subunit protein eS17B

2

3

High-throughput

0.558

High

546460

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.552

High

381287

H2B1
Histone H2B.1

1

4

High-throughput

0.536

High

722295

XPO1
Exportin-1

1

1

High-throughput

0.536

High

1043295

HAS1
ATP-dependent RNA helicase HAS1

1

6

High-throughput

0.536

High

1059252

NOP6
Nucleolar protein 6

1

1

High-throughput

0.536

High

1059253

NOP12
Nucleolar protein 12

1

1

High-throughput

0.536

High

1059265

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.536

High

585391

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.515

High

657004

BUR1
Serine/threonine-protein kinase BUR1

1

2

High-throughput

0.515

High

789845

YC16
UPF0743 protein YCR087C-A

1

1

High-throughput

0.515

High

825433

PRK1
Actin-regulating kinase PRK1

1

2

High-throughput

0.515

High

918837

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.515

High

923263

ESF2
Pre-rRNA-processing protein ESF2

1

3

High-throughput

0.515

High

1046262

UTP15
U3 small nucleolar RNA-associated protein 15

1

6

High-throughput

0.515

High

1059257

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.515

High

1059259

YRA1
RNA annealing protein YRA1

1

2

High-throughput

0.515

High

376244

RAS2
Ras-like protein 2

1

0

High-throughput

0.513

High

454493

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

694657

SPT5
Transcription elongation factor SPT5

1

0

Small-scale

0.513

High

776657

DEF1
RNA polymerase II degradation factor 1

1

0

Small-scale

0.513

High

810672

SSN3
Meiotic mRNA stability protein kinase SSN3

1

0

High-throughput

0.513

High

815248

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.513

High

816913

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.513

High

1049106

YM94
Uncharacterized protein YMR315W

1

0

Small-scale

0.513

High

700300

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.493

High

807930

BFR1
Nuclear segregation protein BFR1

1

0

High-throughput

0.493

High

843279

KRI1
Protein KRI1

1

0

High-throughput

0.493

High

1056397

TSR2
Pre-rRNA-processing protein TSR2

1

0

High-throughput

0.493

High

436531

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

502754

RS21A
Small ribosomal subunit protein eS21A

1

2

High-throughput

0.479

High

513915

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.479

High

514193

RS16B
Small ribosomal subunit protein uS9B

1

2

High-throughput

0.479

High

646547

RAD53
Serine/threonine-protein kinase RAD53

1

3

High-throughput

0.479

High

666554

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.479

High

671171

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

677585

KRR1
KRR1 small subunit processome component

1

3

High-throughput

0.479

High

677970

YCQ6
Uncharacterized protein YCR016W

1

1

High-throughput

0.479

High

678256

BUD23
18S rRNA

1

1

High-throughput

0.479

High

692635

NSR1
Nuclear localization sequence-binding protein

1

1

High-throughput

0.479

High

708320

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

710009

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

734212

EF2
Elongation factor 2

1

1

Small-scale

0.479

High

735186

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

763856

SKI2
Antiviral helicase SKI2

1

3

High-throughput

0.479

High

778558

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

795555

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

802747

RS27B
Small ribosomal subunit protein eS27B

1

3

High-throughput

0.479

High

812021

RS14B
Small ribosomal subunit protein uS11B

1

4

High-throughput

0.479

High

815389

RS26A
Small ribosomal subunit protein eS26A

1

1

High-throughput

0.479

High

844631

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

858078

RSSA2
Small ribosomal subunit protein uS2B

1

6

High-throughput

0.479

High

864971

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

870688

RS7B
Small ribosomal subunit protein eS7B

1

3

High-throughput

0.479

High

897516

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.479

High

925090

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

1031058

NOP3
Serine/arginine

1

5

High-throughput

0.479

High

1038757

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

1046054

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

1051616

HRQ1
ATP-dependent helicase HRQ1

1

4

Small-scale

0.479

High

1059258

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

1059262

RS21B
Small ribosomal subunit protein eS21B

1

2

High-throughput

0.479

High

393413

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.458

High

557637

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

0

High-throughput

0.458

High

594591

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

639901

DAL82
Protein DAL82

1

0

High-throughput

0.458

High

649679

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.458

High

803280

OTU2
OTU domain-containing protein 2

1

0

High-throughput

0.458

High

1054851

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

481783

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

676395

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

752793

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

819924

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

410360

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433870

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

455449

RS19B
Small ribosomal subunit protein eS19B

1

4

High-throughput

0.437

High

502675

RS25B
Small ribosomal subunit protein eS25B

1

2

High-throughput

0.437

High

503524

RS28B
Small ribosomal subunit protein eS28B

1

2

High-throughput

0.437

High

504439

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

812699

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

831864

RS29A
Small ribosomal subunit protein uS14A

1

1

High-throughput

0.437

High

831891

RS29B
Small ribosomal subunit protein uS14B

1

1

High-throughput

0.437

High

918471

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

1059255

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

1059263

RS25A
Small ribosomal subunit protein eS25A

1

2

High-throughput

0.437

High

1059264

RS28A
Small ribosomal subunit protein eS28A

1

2

High-throughput

0.437

High

592527

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

514371

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

550699

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025