HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	28213521, 8183561, 10092678, 25921289, 29715200, 9856458, 12446789, 10708759, 8226808
Identification Methods	affinity chromatography technology, pull down, two hybrid, coimmunoprecipitation, competition binding
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 583
+	Mm
		957230 NTRK1_MOUSE (1-796): 0: 600: 85.86		SHC1_MOUSE (1-583): 0: 527: 94.51
+	Hs
		507872 FGFR1_HUMAN (195-794): 0: 545: 26.34		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		385029 NTRK1_HUMAN (1-796): 0: 621: 100.00		SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53
+	Rn
		728445 NTRK1_RAT (1-796): 0: 592: 85.61		SHC1_RAT (111-583): 1.45e-142: 422: 94.72
+	Hs
		385257 NTRK1_HUMAN (1-796): 0: 621: 100.00		SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47
+	Mm
		1112475 NTRK1_MOUSE (1-796): 0: 600: 85.86		SHC3_MOUSE (128-582): 1.14e-111: 343: 53.26
+	Hs
		384538 NTRK1_HUMAN (1-796): 0: 621: 100.00		VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97
+	Hs
		384213 NTRK1_HUMAN (1-796): 0: 621: 100.00		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		384316 NTRK1_HUMAN (1-796): 0: 621: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		385265 NTRK1_HUMAN (1-796): 0: 621: 100.00		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		129160 NTRK1_HUMAN (1-796): 0: 621: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		507829 FGFR1_HUMAN (195-794): 0: 545: 26.34		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Rn
		728446 NTRK1_RAT (1-796): 0: 592: 85.61		SH2B1_RAT (370-582): 1.94e-33: 138: 24.78
+	Hs
		208983 FGFR1_HUMAN (195-794): 0: 545: 26.34		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		507832 FGFR1_HUMAN (195-794): 0: 545: 26.34		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		384619 NTRK1_HUMAN (1-796): 0: 621: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		507870 FGFR1_HUMAN (195-794): 0: 545: 26.34		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		129184 FGFR1_HUMAN (195-794): 0: 545: 26.34		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Rn
		728442 NTRK1_RAT (1-796): 0: 592: 85.61		GRB2_RAT (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		507939 FGFR1_HUMAN (195-794): 0: 545: 26.34		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48