Protein: GLYC
Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)

Gene: GLYC, SHMT1
Organism: Homo sapiens
Interactions: 52
UniProt ID: P34896

Gene Ontology (top 5):
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0004372 - glycine hydroxymethyltransferase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

713432

GLYC
Serine hydroxymethyltransferase, cytosolic

3

5

High-throughput

0.861

High

713433

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

5

High-throughput

0.811

High

713436

MK09
Mitogen-activated protein kinase 9

4

0

High-throughput

0.668

High

649044

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

1

High-throughput

0.628

High

640338

DDX6
Probable ATP-dependent RNA helicase DDX6

2

3

High-throughput

0.606

High

713446

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

2

0

High-throughput

0.602

High

713454

DPYL5
Dihydropyrimidinase-related protein 5

2

0

High-throughput

0.602

High

226661

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

713453

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

507544

PIM1
Serine/threonine-protein kinase pim-1

1

1

High-throughput

0.541

High

713442

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.536

High

713449

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

713459

DOCK5
Dedicator of cytokinesis protein 5

1

1

High-throughput

0.536

High

304527

PRS23
Serine protease 23

1

0

High-throughput

0.518

High

483642

ST1A3
Sulfotransferase 1A3

1

1

High-throughput

0.515

High

515809

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

713439

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.513

High

713440

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

713441

AMPD2
AMP deaminase 2

1

0

High-throughput

0.513

High

713462

FBX2
F-box only protein 2

1

0

High-throughput

0.513

High

713463

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

483652

ST1A4
Sulfotransferase 1A4

1

1

High-throughput

0.481

High

243311

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

496423

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.479

High

552060

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

650490

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

713434

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

713435

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

713437

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

1

Small-scale

0.479

High

713438

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

713443

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

713444

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

713445

ABRX2
BRISC complex subunit Abraxas 2

1

1

Small-scale

0.479

High

713448

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

713450

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

713451

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

713457

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

713461

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

271689

DEDD
Death effector domain-containing protein

1

0

High-throughput

0.460

High

214116

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

713455

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.458

High

713458

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

401504

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

566006

INAR1
Interferon alpha/beta receptor 1

1

2

Small-scale

0.437

High

607898

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.437

High

713447

NBEL2
Neurobeachin-like protein 2

1

0

High-throughput

0.426

High

713452

FRMD6
FERM domain-containing protein 6

1

0

High-throughput

0.426

High

713456

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.426

High

713460

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.316

High

241274

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

0

High-throughput

0.279

Low

199225

LEU1
Leukemia-associated protein 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024