HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 870
+	Hs
		384691 NTRK1_HUMAN (1-796): 0: 621: 100.00		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		507913 FGFR1_HUMAN (195-794): 0: 545: 26.34		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		607921 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		601480 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		508270 FGFR1_HUMAN (195-794): 0: 545: 26.34		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		609215 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		608198 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		601616 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		609615 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		128396 NTRK1_HUMAN (1-796): 0: 621: 100.00		DNM1L_HUMAN (6-743): 0: 787: 39.13
+	At
		1324891 BRL3_ARATH (96-427): 1.78e-20: 99.3: 10.88		DRP1E_ARATH (537-740): 9.28e-33: 137: 11.68