Protein: CRYAB
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)

Gene: CRYAB
Organism: Homo sapiens
Interactions: 183
UniProt ID: P02511

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001666 - response to hypoxia
GO:0002088 - lens development in camera-type eye
GO:0005198 - structural molecule activity
GO:0005212 - structural constituent of eye lens

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

384597

CRYAB
Alpha-crystallin B chain

27

15

Small-scale

0.993

High

384351

CRYAA
Alpha-crystallin A chain

19

15

Small-scale

0.991

High

384604

HSPB1
Heat shock protein beta-1

14

16

Small-scale

0.986

High

384675

HSPB2
Heat shock protein beta-2

5

15

Small-scale

0.929

High

384605

A4
Amyloid-beta precursor protein

7

2

Small-scale

0.745

High

384745

HSPB8
Heat shock protein beta-8

1

15

Small-scale

0.713

High

347454

BAG3
BAG family molecular chaperone regulator 3

4

9

Small-scale

0.703

High

384633

SYUA
Alpha-synuclein

4

4

Small-scale

0.696

High

384632

CTNB1
Catenin beta-1

4

4

Small-scale

0.691

High

384739

NYNRI
Protein NYNRIN

4

3

High-throughput

0.691

High

384610

CRGD
Gamma-crystallin D

4

13

Small-scale

0.685

High

384639

CRBB2
Beta-crystallin B2

3

13

Small-scale

0.678

High

384650

GEMI4
Gem-associated protein 4

3

1

High-throughput

0.667

High

384676

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

3

1

High-throughput

0.667

High

384686

C2D1A
Coiled-coil and C2 domain-containing protein 1A

3

5

High-throughput

0.667

High

384723

RBM24
RNA-binding protein 24

3

2

High-throughput

0.667

High

384744

CDC23
Cell division cycle protein 23 homolog

3

3

High-throughput

0.667

High

384749

PRLD1
PRELI domain-containing protein 1, mitochondrial

3

1

High-throughput

0.667

High

384636

CASP3
Caspase-3

3

10

Small-scale

0.664

High

279609

CISY
Citrate synthase, mitochondrial

3

4

Small-scale

0.655

High

384713

SEH1
Nucleoporin SEH1

3

8

High-throughput

0.650

High

156384

HSPB6
Heat shock protein beta-6

1

15

Small-scale

0.647

High

384609

CRGC
Gamma-crystallin C

2

13

Small-scale

0.643

High

384705

SMCR8
Guanine nucleotide exchange protein SMCR8

3

0

High-throughput

0.638

High

384720

TIRR
Tudor-interacting repair regulator protein

3

0

High-throughput

0.638

High

384607

CRBA1
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]

2

13

Small-scale

0.634

High

384710

TFG
Protein TFG

2

2

High-throughput

0.628

High

384714

GMCL1
Germ cell-less protein-like 1

2

3

High-throughput

0.628

High

384742

DDX20
Probable ATP-dependent RNA helicase DDX20

2

8

Small-scale

0.620

High

384626

CCND1
G1/S-specific cyclin-D1

2

5

Small-scale

0.619

High

384613

TPC2B
Trafficking protein particle complex subunit 2B

3

0

High-throughput

0.613

High

384640

MAP1B
Microtubule-associated protein 1B

2

8

High-throughput

0.611

High

384674

CC85B
Coiled-coil domain-containing protein 85B

2

3

High-throughput

0.611

High

384717

LENG8
Leukocyte receptor cluster member 8

2

5

High-throughput

0.611

High

384682

LBH
Protein LBH

2

0

Small-scale

0.609

High

66573

CC85C
Coiled-coil domain-containing protein 85C

3

3

High-throughput

0.609

High

384634

MDHM
Malate dehydrogenase, mitochondrial

2

4

Small-scale

0.602

High

384695

GPBP1
Vasculin

2

0

High-throughput

0.602

High

384747

OAZ3
Ornithine decarboxylase antizyme 3

2

0

High-throughput

0.602

High

384752

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.602

High

322568

FBX21
F-box only protein 21

2

0

High-throughput

0.585

High

384603

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

384645

CASP7
Caspase-7

2

10

Small-scale

0.584

High

384678

KRA61
Keratin-associated protein 6-1

2

0

High-throughput

0.580

High

377023

NEU2
Vasopressin-neurophysin 2-copeptin

2

0

Small-scale

0.577

High

384602

MAS
Proto-oncogene Mas

2

4

High-throughput

0.574

High

384638

GDF5
Growth/differentiation factor 5

2

1

High-throughput

0.574

High

384622

VEGFA
Vascular endothelial growth factor A, long form

2

1

Small-scale

0.563

High

384658

BAX
Apoptosis regulator BAX

1

6

Small-scale

0.561

High

384659

B2CL1
Bcl-2-like protein 1

1

6

Small-scale

0.561

High

384625

CRYGS
Gamma-crystallin S

1

13

Small-scale

0.554

High

384731

GORS2
Golgi reassembly-stacking protein 2

2

2

High-throughput

0.553

High

384627

PSA3
Proteasome subunit alpha type-3

1

4

Small-scale

0.552

High

384671

SCN5A
Sodium channel protein type 5 subunit alpha

1

0

Small-scale

0.549

High

384624

CAN3
Calpain-3

1

2

High-throughput

0.541

High

384662

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.541

High

133837

FOXN3
Forkhead box protein N3

1

3

High-throughput

0.536

High

301789

ANXA9
Annexin A9

1

4

High-throughput

0.536

High

348923

LATS1
Serine/threonine-protein kinase LATS1

1

9

High-throughput

0.536

High

370507

FOS
Protein c-Fos

1

1

High-throughput

0.536

High

384618

ADT3
ADP/ATP translocase 3

1

10

High-throughput

0.536

High

384630

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

384660

FSTL1
Follistatin-related protein 1

1

1

High-throughput

0.536

High

384661

FOXD4
Forkhead box protein D4

1

3

High-throughput

0.536

High

384697

TEX14
Inactive serine/threonine-protein kinase TEX14

1

11

High-throughput

0.536

High

384724

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

11

High-throughput

0.536

High

384729

S2532
Solute carrier family 25 member 32

1

12

High-throughput

0.536

High

384735

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

384743

PHF11
PHD finger protein 11

1

5

High-throughput

0.536

High

384722

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

Small-scale

0.529

High

384649

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.518

High

384612

ANXA4
Annexin A4

1

3

High-throughput

0.515

High

384651

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.515

High

384669

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.515

High

384706

PRUN2
Protein prune homolog 2

1

1

High-throughput

0.515

High

384715

HSFY1
Heat shock transcription factor, Y-linked

1

2

High-throughput

0.515

High

194442

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

384601

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.513

High

384606

7B2
Neuroendocrine protein 7B2

1

0

High-throughput

0.513

High

384648

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

384657

AMPD2
AMP deaminase 2

1

0

High-throughput

0.513

High

384691

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.513

High

384692

TSN33
Tetraspanin-33

1

0

High-throughput

0.513

High

384694

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.513

High

384704

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.513

High

384711

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

384721

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.513

High

384725

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

384740

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.513

High

384751

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

384619

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

4

Small-scale

0.512

High

384620

CADH1
Cadherin-1

1

0

Small-scale

0.512

High

365926

LALBA
Alpha-lactalbumin

1

1

Small-scale

0.501

High

384621

GFAP
Glial fibrillary acidic protein

1

9

Small-scale

0.501

High

384623

DESM
Desmin

1

9

Small-scale

0.501

High

384629

MIP
Lens fiber major intrinsic protein

1

1

Small-scale

0.501

High

384643

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

1

Small-scale

0.501

High

384653

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

Small-scale

0.501

High

384654

HBA
Hemoglobin subunit alpha

1

2

Small-scale

0.501

High

137166

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.493

High

384681

FNDC1
Fibronectin type III domain-containing protein 1

1

5

High-throughput

0.489

High

384701

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

1

High-throughput

0.489

High

384707

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

123309

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.481

High

164507

TNPO2
Transportin-2

1

2

High-throughput

0.481

High

295971

TPC6A
Trafficking protein particle complex subunit 6A

1

2

High-throughput

0.481

High

384679

KR195
Keratin-associated protein 19-5

1

2

High-throughput

0.481

High

384696

KRA81
Keratin-associated protein 8-1

1

3

High-throughput

0.481

High

384753

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.481

High

361040

SODC
Superoxide dismutase [Cu-Zn]

1

0

Small-scale

0.480

High

240440

PRKN
E3 ubiquitin-protein ligase parkin

1

5

Small-scale

0.479

High

384608

NFL
Neurofilament light polypeptide

1

9

High-throughput

0.479

High

384614

BCL2
Apoptosis regulator Bcl-2

1

6

Small-scale

0.479

High

384615

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

384631

HSP74
Heat shock 70 kDa protein 4

1

5

Small-scale

0.479

High

384637

CASP2
Caspase-2

1

11

Small-scale

0.479

High

384641

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

384646

CASP9
Caspase-9

1

10

Small-scale

0.479

High

384647

CASP6
Caspase-6

1

10

Small-scale

0.479

High

384656

XIAP
E3 ubiquitin-protein ligase XIAP

1

3

Small-scale

0.479

High

384663

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

384667

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

384672

MDC1
Mediator of DNA damage checkpoint protein 1

1

5

High-throughput

0.479

High

384673

CASP8
Caspase-8

1

10

Small-scale

0.479

High

384685

CROCC
Rootletin

1

9

High-throughput

0.479

High

384688

CASPC
Inactive caspase-12

1

10

Small-scale

0.479

High

384690

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

384693

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

10

High-throughput

0.479

High

384702

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

384708

ASB5
Ankyrin repeat and SOCS box protein 5

1

7

High-throughput

0.479

High

384709

TITIN
Titin

1

12

Small-scale

0.479

High

384712

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.479

High

384716

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

4

Small-scale

0.479

High

384730

FA83D
Protein FAM83D

1

3

High-throughput

0.479

High

384732

PIDD1
p53-induced death domain-containing protein 1

1

3

Small-scale

0.479

High

384733

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

2

High-throughput

0.479

High

384748

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

Small-scale

0.479

High

384687

CORO6
Coronin-6

1

1

High-throughput

0.470

High

384689

ATL4
ADAMTS-like protein 4

1

1

High-throughput

0.470

High

384741

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

Small-scale

0.460

High

275800

CAD16
Cadherin-16

1

0

Small-scale

0.458

High

384599

ALBU
Albumin

1

0

Small-scale

0.458

High

384616

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

384617

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

384628

CD40L
CD40 ligand

1

0

Small-scale

0.458

High

384644

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

384655

CRADD
Death domain-containing protein CRADD

1

0

Small-scale

0.458

High

384665

SMAD4
Mothers against decapentaplegic homolog 4

1

0

Small-scale

0.458

High

384668

BMPR2
Bone morphogenetic protein receptor type-2

1

0

Small-scale

0.458

High

384718

TPPC9
Trafficking protein particle complex subunit 9

1

0

High-throughput

0.458

High

384734

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

384737

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.458

High

384600

ALDOA
Fructose-bisphosphate aldolase A

1

4

High-throughput

0.457

High

384670

DCTN1
Dynactin subunit 1

1

10

High-throughput

0.457

High

384683

Q5BJH1
PSAP protein

1

2

High-throughput

0.457

High

216605

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.445

High

384635

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

384652

LYSC
Lysozyme C

1

1

Small-scale

0.445

High

384664

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

384738

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

4

High-throughput

0.445

High

105070

APRIO
Alternative prion protein

1

1

Small-scale

0.439

High

384680

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.437

High

384728

TM168
Transmembrane protein 168

1

1

Small-scale

0.437

High

384736

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

384746

COHA1
Collagen alpha-1(XVII) chain

1

1

High-throughput

0.437

High

384698

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

0

High-throughput

0.426

High

384703

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

0

High-throughput

0.426

High

384750

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

377347

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

Small-scale

0.408

High

384666

SQSTM
Sequestosome-1

1

5

Small-scale

0.408

High

384700

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

376939

NGF
Beta-nerve growth factor

1

0

Small-scale

0.391

High

384611

FGF2
Fibroblast growth factor 2

1

0

Small-scale

0.391

High

142195

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.282

High

384642

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

384677

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

384684

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

384699

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

384719

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

384727

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

384598

APOC2
Apolipoprotein C-II

1

0

Small-scale

0.261

Low

384726

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025