HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0030425 - dendrite GO:0042803 - protein homodimerization activity GO:0043025 - neuronal cell body GO:0043547 - positive regulation of GTPase activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 317
+	Hs
		384596 NTRK1_HUMAN (1-796): 0: 621: 100.00		WDR5_HUMAN (3-219): 3.42e-62: 202: 26.70
+	Hs
		384438 NTRK1_HUMAN (1-796): 0: 621: 100.00		LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43
+	Hs
		385480 NTRK1_HUMAN (1-796): 0: 621: 100.00		TBL1R_HUMAN (188-316): 1.53e-14: 76: 15.86
+	Hs
		609202 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43
+	Hs
		435605 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		411353 INSR_HUMAN (493-777): 3e-68: 248: 42.62		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		929718 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		666573 LTK_HUMAN (502-790): 3.09e-60: 221: 41.64		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		169170 MUSK_HUMAN (171-374): 2.86e-13: 75.8: 18.61		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Hs
		994668 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		SNR40_HUMAN (226-317): 2.08e-15: 77.7: 22.34
+	Hs
		1313658 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		KTNB1_HUMAN (10-213): 1.19e-17: 85.5: 28.29