Protein: CCND2
G1/S-specific cyclin-D2

Gene: CCND2
Organism: Homo sapiens
Interactions: 144
UniProt ID: P30279

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549067

CDK4
Cyclin-dependent kinase 4

18

20

Small-scale

0.987

High

718771

CDN1A
Cyclin-dependent kinase inhibitor 1

17

20

Small-scale

0.987

High

718803

CDK5
Cyclin-dependent kinase 5

12

20

Small-scale

0.985

High

718802

CDK6
Cyclin-dependent kinase 6

7

20

Small-scale

0.962

High

667568

CDK2
Cyclin-dependent kinase 2

7

20

Small-scale

0.957

High

718778

CDN1B
Cyclin-dependent kinase inhibitor 1B

6

20

Small-scale

0.952

High

718781

CDN1C
Cyclin-dependent kinase inhibitor 1C

3

20

High-throughput

0.861

High

443207

CDK1
Cyclin-dependent kinase 1

1

20

High-throughput

0.691

High

442610

RB
Retinoblastoma-associated protein

4

18

Small-scale

0.688

High

718806

RBL2
Retinoblastoma-like protein 2

3

18

High-throughput

0.667

High

718837

Q96TE0
Cyclin-dependent kinase inhibitor 1B

1

20

Small-scale

0.665

High

718774

CDN2A
Cyclin-dependent kinase inhibitor 2A

3

8

Small-scale

0.655

High

169970

AURKA
Aurora kinase A

1

9

High-throughput

0.647

High

400350

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.647

High

666947

CCNE1
G1/S-specific cyclin-E1

1

5

High-throughput

0.647

High

718762

CCND2
G1/S-specific cyclin-D2

1

6

High-throughput

0.647

High

718764

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

High-throughput

0.647

High

718779

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

20

High-throughput

0.647

High

718784

CDK7
Cyclin-dependent kinase 7

1

20

Small-scale

0.647

High

718785

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

20

High-throughput

0.647

High

718819

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.647

High

718822

MK14
Mitogen-activated protein kinase 14

1

20

High-throughput

0.647

High

718839

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

6

High-throughput

0.647

High

718846

LATS2
Serine/threonine-protein kinase LATS2

1

6

High-throughput

0.647

High

718804

H11
Histone H1.1

2

9

Small-scale

0.602

High

718767

PCGF2
Polycomb group RING finger protein 2

1

3

Small-scale

0.589

High

718808

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

10

High-throughput

0.579

High

718852

FBXL2
F-box/LRR-repeat protein 2

1

10

Small-scale

0.561

High

718813

DMP1
Dentin matrix acidic phosphoprotein 1

1

0

Small-scale

0.537

High

550869

PCNA
Proliferating cell nuclear antigen

1

5

High-throughput

0.536

High

718783

PEX5
Peroxisomal targeting signal 1 receptor

1

6

High-throughput

0.536

High

718826

CYTSA
Cytospin-A

1

2

High-throughput

0.536

High

718829

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

718836

NEB2
Neurabin-2

1

2

High-throughput

0.536

High

458290

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.518

High

295458

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

2

Small-scale

0.501

High

362178

ABL1
Tyrosine-protein kinase ABL1

1

3

Small-scale

0.501

High

410651

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

4

High-throughput

0.501

High

521215

ARAF
Serine/threonine-protein kinase A-Raf

1

5

High-throughput

0.501

High

593285

PGFRA
Platelet-derived growth factor receptor alpha

1

3

High-throughput

0.501

High

648433

FGFR4
Fibroblast growth factor receptor 4

1

3

High-throughput

0.501

High

693244

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.501

High

718773

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

High-throughput

0.501

High

718775

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

8

High-throughput

0.501

High

718776

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

9

High-throughput

0.501

High

718790

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

718805

TF65
Transcription factor p65

1

4

High-throughput

0.501

High

718823

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

High-throughput

0.501

High

718832

TSC1
Hamartin

1

2

High-throughput

0.501

High

718833

KAT2A
Histone acetyltransferase KAT2A

1

12

High-throughput

0.501

High

718842

GLIS2
Zinc finger protein GLIS2

1

2

High-throughput

0.501

High

718847

RASF1
Ras association domain-containing protein 1

1

1

High-throughput

0.501

High

718855

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.501

High

718830

TEX11
Testis-expressed protein 11

1

1

High-throughput

0.481

High

162910

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

571180

HGF
Hepatocyte growth factor

1

0

High-throughput

0.480

High

591229

CD44
CD44 antigen

1

0

High-throughput

0.480

High

718768

MERL
Merlin

1

0

High-throughput

0.480

High

718810

GRM1
Metabotropic glutamate receptor 1

1

0

High-throughput

0.480

High

718816

BECN1
Beclin-1

1

0

High-throughput

0.480

High

718818

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.480

High

718850

SRTD1
SERTA domain-containing protein 1

1

0

Small-scale

0.480

High

131133

CLIC1
Chloride intracellular channel protein 1

1

1

Small-scale

0.479

High

131337

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

8

Small-scale

0.479

High

210871

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.479

High

226711

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

7

Small-scale

0.479

High

228970

AKAP8
A-kinase anchor protein 8

1

4

Small-scale

0.479

High

240850

PRKN
E3 ubiquitin-protein ligase parkin

1

7

Small-scale

0.479

High

415376

HSPB1
Heat shock protein beta-1

1

7

Small-scale

0.479

High

442244

GELS
Gelsolin

1

3

Small-scale

0.479

High

578396

BRAF
Serine/threonine-protein kinase B-raf

1

6

High-throughput

0.479

High

610240

PRS6A
26S proteasome regulatory subunit 6A

1

7

Small-scale

0.479

High

647484

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.479

High

681266

PSA3
Proteasome subunit alpha type-3

1

3

Small-scale

0.479

High

694707

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.479

High

700988

PSB6
Proteasome subunit beta type-6

1

3

Small-scale

0.479

High

718763

DNJA1
DnaJ homolog subfamily A member 1

1

3

Small-scale

0.479

High

718766

HS71L
Heat shock 70 kDa protein 1-like

1

4

Small-scale

0.479

High

718769

RFA3
Replication protein A 14 kDa subunit

1

3

Small-scale

0.479

High

718770

PRS7
26S proteasome regulatory subunit 7

1

5

Small-scale

0.479

High

718772

STA5A
Signal transducer and activator of transcription 5A

1

5

Small-scale

0.479

High

718777

PRS6B
26S proteasome regulatory subunit 6B

1

4

Small-scale

0.479

High

718780

TSC2
Tuberin

1

5

Small-scale

0.479

High

718782

F10A1
Hsc70-interacting protein

1

4

Small-scale

0.479

High

718786

XPO2
Exportin-2

1

7

Small-scale

0.479

High

718788

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

5

Small-scale

0.479

High

718791

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

718792

PRS4
26S proteasome regulatory subunit 4

1

4

Small-scale

0.479

High

718793

PRS8
26S proteasome regulatory subunit 8

1

6

Small-scale

0.479

High

718796

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

Small-scale

0.479

High

718799

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

13

Small-scale

0.479

High

718800

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.479

High

718801

TBB4B
Tubulin beta-4B chain

1

2

Small-scale

0.479

High

718807

FLII
Protein flightless-1 homolog

1

4

Small-scale

0.479

High

718811

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.479

High

718812

SKP2
S-phase kinase-associated protein 2

1

10

Small-scale

0.479

High

718814

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

10

Small-scale

0.479

High

718825

ACTBL
Beta-actin-like protein 2

1

1

Small-scale

0.479

High

718827

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

718828

H2AV
Histone H2A.V

1

1

Small-scale

0.479

High

718831

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

1

Small-scale

0.479

High

718834

DTBP1
Dysbindin

1

3

Small-scale

0.479

High

718841

TBB6
Tubulin beta-6 chain

1

2

Small-scale

0.479

High

718844

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

7

Small-scale

0.479

High

718848

TBA8
Tubulin alpha-8 chain

1

2

Small-scale

0.479

High

718856

STRAP
Serine-threonine kinase receptor-associated protein

1

12

Small-scale

0.479

High

718857

TLN2
Talin-2

1

1

Small-scale

0.479

High

718858

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

1

Small-scale

0.479

High

128160

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.458

High

158124

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.458

High

223986

GET3
ATPase GET3

1

0

Small-scale

0.458

High

275848

ZPR1
Zinc finger protein ZPR1

1

0

Small-scale

0.458

High

418850

H2A1B
Histone H2A type 1-B/E

1

0

Small-scale

0.458

High

443676

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

Small-scale

0.458

High

445134

S10A6
Protein S100-A6

1

0

Small-scale

0.458

High

476568

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.458

High

666738

MYL9
Myosin regulatory light polypeptide 9

1

0

Small-scale

0.458

High

718787

PSA
Puromycin-sensitive aminopeptidase

1

0

Small-scale

0.458

High

718789

IF6
Eukaryotic translation initiation factor 6

1

0

Small-scale

0.458

High

718794

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

Small-scale

0.458

High

718795

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.458

High

718797

DYLT1
Dynein light chain Tctex-type 1

1

0

Small-scale

0.458

High

718798

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

Small-scale

0.458

High

718809

CBX3
Chromobox protein homolog 3

1

0

Small-scale

0.458

High

718815

DCTN2
Dynactin subunit 2

1

0

Small-scale

0.458

High

718817

PLEC
Plectin

1

0

Small-scale

0.458

High

718820

SEPT7
Septin-7

1

0

Small-scale

0.458

High

718821

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

Small-scale

0.458

High

718835

NUDC1
NudC domain-containing protein 1

1

0

Small-scale

0.458

High

718838

PFD5
Prefoldin subunit 5

1

0

Small-scale

0.458

High

718843

API5
Apoptosis inhibitor 5

1

0

Small-scale

0.458

High

718851

PFD2
Prefoldin subunit 2

1

0

Small-scale

0.458

High

718853

PSME2
Proteasome activator complex subunit 2

1

0

Small-scale

0.458

High

471998

MET
Hepatocyte growth factor receptor

1

1

High-throughput

0.457

High

622531

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.457

High

718845

NPDC1
Neural proliferation differentiation and control protein 1

1

2

Small-scale

0.457

High

710082

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.261

Low

718765

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.261

Low

718824

ABCB5
ATP-binding cassette sub-family B member 5

1

0

High-throughput

0.261

Low

718840

TTYH2
Protein tweety homolog 2

1

0

High-throughput

0.261

Low

718854

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.261

Low

251863

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

Small-scale

0.249

Low

718849

TMOD3
Tropomodulin-3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025