HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: PFKAP (Q01813)
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)
Gene: PFKP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 784
+	Hs
		384121 NTRK1_HUMAN (1-796): 0: 621: 100.00		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		507955 FGFR1_HUMAN (195-794): 0: 545: 26.34		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		966706 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		607944 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		601497 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		437757 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Mm
		519479 PTK7_MOUSE (201-781): 5.12e-148: 462: 27.17		PFKAL_MOUSE (19-779): 0: 1023: 69.42
+	Hs
		435613 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		411357 INSR_HUMAN (493-777): 3e-68: 248: 42.62		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		966789 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		411276 INSR_HUMAN (493-777): 3e-68: 248: 42.62		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		384225 NTRK1_HUMAN (1-796): 0: 621: 100.00		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571668 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		571725 DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03