HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene: WRN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0042803 - protein homodimerization activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 1432
+	Hs
		384450 NTRK1_HUMAN (1-796): 0: 621: 100.00		RECQ1_HUMAN (461-1117): 3.09e-152: 478: 26.11
+	Hs
		385116 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX42_HUMAN (309-900): 1.25e-131: 432: 13.75
+	Hs
		385053 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX46_HUMAN (278-1201): 6e-120: 402: 12.60
+	Hs
		133833 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX3X_HUMAN (354-901): 6.63e-119: 389: 14.85
+	Hs
		385284 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX17_HUMAN (469-955): 1.98e-117: 387: 16.54
+	Hs
		384224 NTRK1_HUMAN (1-796): 0: 621: 100.00		DDX5_HUMAN (469-892): 8.41e-112: 368: 16.96
+	Hs
		385599 NTRK1_HUMAN (1-796): 0: 621: 100.00		EXD2_HUMAN (73-227): 1.43e-11: 71.2: 32.72
+	Rn
		112169 INSR_RAT (493-777): 7.31e-66: 241: 41.95		M0R9C6_RAT (294-920): 1.73e-107: 357: 13.55