Protein: PSB8
Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)

Gene: PSB8, PSMB8
Organism: Homo sapiens
Interactions: 85
UniProt ID: P28062

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004175 - endopeptidase activity
GO:0004298 - threonine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

681105

PSA2
Proteasome subunit alpha type-2

6

20

Small-scale

0.935

High

700477

PSB7
Proteasome subunit beta type-7

5

19

Small-scale

0.910

High

700431

PSB9
Proteasome subunit beta type-9

4

19

Small-scale

0.885

High

700487

POMP
Proteasome maturation protein

3

15

Small-scale

0.868

High

633602

PSB1
Proteasome subunit beta type-1

3

20

Small-scale

0.850

High

700434

PSB6
Proteasome subunit beta type-6

3

19

Small-scale

0.849

High

680776

PSA1
Proteasome subunit alpha type-1

3

20

Small-scale

0.847

High

681574

PSA4
Proteasome subunit alpha type-4

3

20

Small-scale

0.847

High

700433

PSB4
Proteasome subunit beta type-4

3

19

Small-scale

0.843

High

700443

PSB3
Proteasome subunit beta type-3

3

20

Small-scale

0.843

High

700460

PSME4
Proteasome activator complex subunit 4

3

12

Small-scale

0.839

High

700448

PSA6
Proteasome subunit alpha type-6

2

20

Small-scale

0.793

High

700486

PSME2
Proteasome activator complex subunit 2

2

20

Small-scale

0.789

High

700461

PCH2
Pachytene checkpoint protein 2 homolog

2

20

High-throughput

0.783

High

700455

PSME1
Proteasome activator complex subunit 1

2

20

Small-scale

0.754

High

700430

PSB8
Proteasome subunit beta type-8

2

19

Small-scale

0.754

High

700432

PSA5
Proteasome subunit alpha type-5

2

20

High-throughput

0.737

High

700481

CLPB
Mitochondrial disaggregase

2

2

High-throughput

0.694

High

165265

PSA7
Proteasome subunit alpha type-7

1

20

High-throughput

0.691

High

681258

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.691

High

700435

PSB5
Proteasome subunit beta type-5

1

19

High-throughput

0.691

High

178000

LSM1
U6 snRNA-associated Sm-like protein LSm1

3

2

High-throughput

0.661

High

700439

PSB10
Proteasome subunit beta type-10

1

19

Small-scale

0.621

High

700453

REL
Proto-oncogene c-Rel

2

8

High-throughput

0.606

High

700457

TRAF3
TNF receptor-associated factor 3

2

6

High-throughput

0.606

High

700463

UBAP2
Ubiquitin-associated protein 2

2

1

High-throughput

0.606

High

700468

IKBD
NF-kappa-B inhibitor delta

2

6

High-throughput

0.606

High

700473

TET5B
Terminal nucleotidyltransferase 5B

2

3

High-throughput

0.606

High

700480

DUS23
Dual specificity protein phosphatase 23

2

3

High-throughput

0.606

High

700485

WWOX
WW domain-containing oxidoreductase

2

2

High-throughput

0.606

High

700492

SNX5
Sorting nexin-5

2

1

High-throughput

0.606

High

700449

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.580

High

700456

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

700474

GNA1
Glucosamine 6-phosphate N-acetyltransferase

2

0

High-throughput

0.580

High

700478

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

563245

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.536

High

610537

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.536

High

700438

TCPZ
T-complex protein 1 subunit zeta

1

4

High-throughput

0.536

High

700442

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.536

High

700445

TCPD
T-complex protein 1 subunit delta

1

4

High-throughput

0.536

High

700450

TCPB
T-complex protein 1 subunit beta

1

5

High-throughput

0.536

High

700471

PSMG2
Proteasome assembly chaperone 2

1

12

High-throughput

0.536

High

700479

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.536

High

361125

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.515

High

415365

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.515

High

421544

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

700436

GRN
Progranulin

1

1

High-throughput

0.515

High

700440

HD
Huntingtin

1

5

High-throughput

0.515

High

700446

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

700458

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.515

High

700464

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.515

High

700489

RNF11
RING finger protein 11

1

15

High-throughput

0.515

High

700447

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

700483

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

700488

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

700437

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.489

High

467235

MDR1
ATP-dependent translocase ABCB1

1

1

Small-scale

0.481

High

700444

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.481

High

271918

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.479

High

289119

PRDM1
PR domain zinc finger protein 1

1

1

Small-scale

0.479

High

533882

IRF1
Interferon regulatory factor 1

1

9

Small-scale

0.479

High

606272

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

700454

UBE3A
Ubiquitin-protein ligase E3A

1

20

High-throughput

0.479

High

700466

NHLC2
NHL repeat-containing protein 2

1

3

High-throughput

0.479

High

700467

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

700469

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

700476

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

3

Small-scale

0.479

High

301349

WFS1
Wolframin

1

1

High-throughput

0.470

High

700451

TAP1
Antigen peptide transporter 1

1

5

Small-scale

0.464

High

700452

TAP2
Antigen peptide transporter 2

1

5

Small-scale

0.464

High

700459

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

20

High-throughput

0.445

High

700470

RNF34
E3 ubiquitin-protein ligase RNF34

1

6

High-throughput

0.445

High

700484

KLH11
Kelch-like protein 11

1

1

High-throughput

0.445

High

700490

FBX7
F-box only protein 7

1

8

High-throughput

0.445

High

700491

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

20

High-throughput

0.445

High

700465

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

700462

TMM31
Transmembrane protein 31

1

8

High-throughput

0.407

High

67293

YJEN3
YjeF N-terminal domain-containing protein 3

2

0

High-throughput

0.316

High

700482

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

325285

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

700441

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

700472

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.279

Low

245874

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.268

Low

700475

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025