HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: L2GL1 (Q15334)
Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)
Gene: LLGL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030424 - axon GO:0031901 - early endosome membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 1064
+	Hs
		1071535 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		L2GL1_HUMAN (1-1064): 0: 1391: 100.00
+	Hs
		1071534 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		L2GL1_HUMAN (1-1064): 0: 1391: 100.00
+	Hs
		434202 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		L2GL1_HUMAN (1-1064): 0: 1391: 100.00
+	Hs
		435650 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		L2GL1_HUMAN (1-1064): 0: 1391: 100.00