HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: CD11B (P21127)
Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)
Gene: CDK11B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38580884
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription GO:0042981 - regulation of apoptotic process GO:0051726 - regulation of cell cycle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 795
+	Hs
		387758 P53_HUMAN (1-393): 0: 619: 100.00		CD11A_HUMAN (1-795): 0: 561: 96.86
+	Hs
		386119 P53_HUMAN (1-393): 0: 619: 100.00		CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96
+	Hs
		385923 P53_HUMAN (1-393): 0: 619: 100.00		CDK1_HUMAN (435-726): 7.24e-138: 411: 41.84
+	Hs
		386533 P53_HUMAN (1-393): 0: 619: 100.00		CDK5_HUMAN (435-729): 1.29e-137: 410: 41.55
+	Mm
		356844 P53_MOUSE (1-393): 0: 589: 77.35		CDK2_MOUSE (435-731): 8.4e-145: 431: 38.15
+	Hs
		175828 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96
+	Hs
		175808 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		CDK1_HUMAN (435-726): 7.24e-138: 411: 41.84
+	Hs
		386332 P53_HUMAN (1-393): 0: 619: 100.00		CDK7_HUMAN (436-760): 1.13e-72: 243: 38.69