HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 22731250, 22074660, 23307557, 19339993, 9891054, 9744860, 12501250, 9288740, 17438265, 17906639, 14612423, 15965232, 14759370, 12724314, 10490106, 23870121, 23796514, 11433299, 15664194, 25753752 and 63 others

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Identification Methods affinity chromatography technology, enzymatic study, unspecified method, pull down, x-ray crystallography, isothermal titration calorimetry, anti tag coimmunoprecipitation, classical fluorescence spectroscopy, nuclear magnetic resonance, molecular sieving and 4 others

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Interaction Type physical association, direct interaction, association, acetylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Creb_binding~P53_TAD, P53_TAD~zf-TAZ, Creb_binding~TAD2, TAD2~zf-TAZ
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001756 - somitogenesis
GO:0002039 - p53 binding
GO:0003677 - DNA binding
and 15 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024