HitPredict - High confidence protein-protein interactions

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: ARF (Q8N726)
Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF)
Gene: CDKN2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.666

Property	Details
Experiments	12640129, 9724636, 35140242, 22653443
Identification Methods	coimmunoprecipitation, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002039 - p53 binding GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus and 15 others more... GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation GO:0010628 - positive regulation of gene expression GO:0032991 - protein-containing complex GO:0043065 - positive regulation of apoptotic process GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050821 - protein stabilization GO:0051726 - regulation of cell cycle GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0090398 - cellular senescence GO:0097371 - MDM2/MDM4 family protein binding GO:0097718 - disordered domain specific binding
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	132

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024