HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: GLSL (Q9UI32)
Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)
Gene: GLS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32807901
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~P53
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0042981 - regulation of apoptotic process GO:0072593 - reactive oxygen species metabolic process
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 602
+	Hs
		386632 P53_HUMAN (1-393): 0: 619: 100.00		ANK3_HUMAN (268-602): 2.18e-50: 190: 15.98
+	Hs
		387827 P53_HUMAN (1-393): 0: 619: 100.00		MYO16_HUMAN (275-602): 8.1e-47: 179: 17.01
+	Mm
		250857 P53_MOUSE (1-393): 0: 589: 77.35		BARD1_MOUSE (402-602): 2.2e-41: 162: 23.38
+	Hs
		386546 P53_HUMAN (1-393): 0: 619: 100.00		ANK2_HUMAN (485-602): 8.63e-29: 124: 22.88
+	Hs
		386364 P53_HUMAN (1-393): 0: 619: 100.00		DAPK1_HUMAN (277-572): 7.6e-27: 118: 15.10
+	Hs
		387535 P53_HUMAN (1-393): 0: 619: 100.00		EHMT1_HUMAN (392-563): 8.71e-21: 99.3: 14.94
+	Hs
		387379 P53_HUMAN (1-393): 0: 619: 100.00		BARD1_HUMAN (514-601): 1.02e-19: 95.5: 24.72
+	Hs
		276130 P53_HUMAN (1-393): 0: 619: 100.00		PSD10_HUMAN (394-560): 2.03e-19: 89.3: 14.79
+	Hs
		387751 P53_HUMAN (1-393): 0: 619: 100.00		ANR26_HUMAN (483-584): 8.64e-15: 80.4: 21.57
+	Mm
		356900 P53_MOUSE (1-393): 0: 589: 77.35		PSD10_MOUSE (394-560): 3.81e-20: 91.6: 15.39
+	Mm
		356872 P53_MOUSE (1-393): 0: 589: 77.35		DAPK1_MOUSE (469-601): 1.07e-17: 89.7: 15.71
+	Mm
		93499 P53_MOUSE (1-393): 0: 589: 77.35		ANR11_MOUSE (472-592): 5.33e-15: 80.9: 29.75