Protein: FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

Gene: FIBB, FGB
Organism: Homo sapiens
Interactions: 200
UniProt ID: P02675

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0005102 - signaling receptor binding
GO:0005198 - structural molecule activity
GO:0005201 - extracellular matrix structural constituent
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

387675

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

2

16

Small-scale

0.737

High

387764

FIBG
Fibrinogen gamma chain

2

16

Small-scale

0.737

High

210658

KLK10
Kallikrein-10

1

5

High-throughput

0.691

High

387842

FNDC1
Fibronectin type III domain-containing protein 1

1

2

High-throughput

0.691

High

387774

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

2

High-throughput

0.667

High

387878

TM237
Transmembrane protein 237

3

0

High-throughput

0.638

High

227045

SYNC
Asparagine--tRNA ligase, cytoplasmic

2

1

High-throughput

0.628

High

249551

SNX3
Sorting nexin-3

2

1

High-throughput

0.628

High

343544

OXSR1
Serine/threonine-protein kinase OSR1

2

3

High-throughput

0.628

High

387776

H2B1J
Histone H2B type 1-J

2

16

High-throughput

0.628

High

387782

PO2F1
POU domain, class 2, transcription factor 1

2

1

High-throughput

0.628

High

387801

GNL1
Guanine nucleotide-binding protein-like 1

2

1

High-throughput

0.628

High

387814

RHOA
Transforming protein RhoA

2

1

High-throughput

0.628

High

387821

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

3

High-throughput

0.628

High

387823

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

5

High-throughput

0.628

High

387826

RHG01
Rho GTPase-activating protein 1

2

1

High-throughput

0.628

High

387827

PPID
Peptidyl-prolyl cis-trans isomerase D

2

1

High-throughput

0.628

High

387830

PAK1
Serine/threonine-protein kinase PAK 1

2

7

High-throughput

0.628

High

387832

PAK2
Serine/threonine-protein kinase PAK 2

2

7

High-throughput

0.628

High

387855

CCYL1
Cyclin-Y-like protein 1

2

1

High-throughput

0.628

High

387887

EIF2A
Eukaryotic translation initiation factor 2A

2

1

High-throughput

0.628

High

387892

SLK
STE20-like serine/threonine-protein kinase

2

5

High-throughput

0.628

High

387912

TES
Testin

2

2

High-throughput

0.628

High

387919

TBC24
TBC1 domain family member 24

2

1

High-throughput

0.628

High

366138

HPT
Haptoglobin

1

10

High-throughput

0.618

High

387765

FINC
Fibronectin

1

9

Small-scale

0.618

High

387788

NDKB
Nucleoside diphosphate kinase B

2

3

High-throughput

0.611

High

387920

DD19B
ATP-dependent RNA helicase DDX19B

2

3

High-throughput

0.611

High

387856

ASCC1
Activating signal cointegrator 1 complex subunit 1

3

2

High-throughput

0.609

High

387773

A4
Amyloid-beta precursor protein

2

6

Small-scale

0.602

High

387794

BLVRB
Flavin reductase

2

0

High-throughput

0.602

High

387798

CGL
Cystathionine gamma-lyase

2

0

High-throughput

0.602

High

387805

KPCI
Protein kinase C iota type

2

0

High-throughput

0.602

High

387811

ADK
Adenosine kinase

2

0

High-throughput

0.602

High

387819

VIGLN
Vigilin

2

0

High-throughput

0.602

High

387822

EF1A2
Elongation factor 1-alpha 2

2

0

High-throughput

0.602

High

387835

PMVK
Phosphomevalonate kinase

2

0

High-throughput

0.602

High

387860

CTBL1
Beta-catenin-like protein 1

2

0

High-throughput

0.602

High

387869

SYAP1
Synapse-associated protein 1

2

0

High-throughput

0.602

High

387872

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.602

High

387890

NAA50
N-alpha-acetyltransferase 50

2

0

High-throughput

0.602

High

387917

PSME2
Proteasome activator complex subunit 2

2

0

High-throughput

0.602

High

387926

TLN1
Talin-1

2

0

High-throughput

0.602

High

387791

1433T
14-3-3 protein theta

2

3

High-throughput

0.601

High

229257

ANGL7
Angiopoietin-related protein 7

1

16

High-throughput

0.575

High

387865

KLK6
Kallikrein-6

1

5

Small-scale

0.575

High

122692

KIF2A
Kinesin-like protein KIF2A

2

2

High-throughput

0.574

High

387824

RING1
E3 ubiquitin-protein ligase RING1

2

4

High-throughput

0.574

High

387840

MK06
Mitogen-activated protein kinase 6

2

2

High-throughput

0.574

High

387866

GPKOW
G-patch domain and KOW motifs-containing protein

2

1

High-throughput

0.574

High

387875

SNX27
Sorting nexin-27

2

8

High-throughput

0.574

High

387884

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

2

2

High-throughput

0.574

High

387900

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

1

High-throughput

0.574

High

387921

SNX6
Sorting nexin-6

2

1

High-throughput

0.574

High

248186

NDK8
Putative nucleoside diphosphate kinase

2

3

High-throughput

0.552

High

194445

P2RX6
P2X purinoceptor 6

1

2

High-throughput

0.536

High

300087

GLRX3
Glutaredoxin-3

1

3

High-throughput

0.536

High

322184

GLSK
Glutaminase kidney isoform, mitochondrial

1

1

High-throughput

0.536

High

351638

SG1D1
Secretoglobin family 1D member 1

1

2

High-throughput

0.536

High

387780

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.536

High

387783

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.536

High

387784

LEG3
Galectin-3

1

6

High-throughput

0.536

High

387787

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.536

High

387793

GRAN
Grancalcin

1

2

High-throughput

0.536

High

387795

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

4

High-throughput

0.536

High

387797

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

387800

SPRE
Sepiapterin reductase

1

3

High-throughput

0.536

High

387812

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

387834

SL9A5
Sodium/hydrogen exchanger 5

1

3

High-throughput

0.536

High

387849

CRDL2
Chordin-like protein 2

1

9

High-throughput

0.536

High

387852

CERS3
Ceramide synthase 3

1

2

High-throughput

0.536

High

387858

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.536

High

387862

DDX1
ATP-dependent RNA helicase DDX1

1

2

High-throughput

0.536

High

387868

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

2

High-throughput

0.536

High

387871

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.536

High

387880

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

4

High-throughput

0.536

High

387881

EGFL8
Epidermal growth factor-like protein 8

1

4

High-throughput

0.536

High

387885

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.536

High

387901

XPP1
Xaa-Pro aminopeptidase 1

1

2

High-throughput

0.536

High

387915

DBNL
Drebrin-like protein

1

4

High-throughput

0.536

High

387916

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.536

High

387792

CALR
Calreticulin

1

2

Small-scale

0.534

High

105076

APRIO
Alternative prion protein

2

4

High-throughput

0.533

High

255730

USO1
General vesicular transport factor p115

1

0

High-throughput

0.513

High

314943

DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

1

0

High-throughput

0.513

High

387778

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.513

High

387786

ICAL
Calpastatin

1

0

High-throughput

0.513

High

387808

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

0

High-throughput

0.513

High

387837

TBCE
Tubulin-specific chaperone E

1

0

High-throughput

0.513

High

387854

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.513

High

387898

CHM1A
Charged multivesicular body protein 1a

1

0

High-throughput

0.513

High

387924

CAB39
Calcium-binding protein 39

1

0

High-throughput

0.513

High

387785

ANXA7
Annexin A7

1

2

High-throughput

0.508

High

387833

GRB7
Growth factor receptor-bound protein 7

1

3

High-throughput

0.508

High

387843

HS904
Putative heat shock protein HSP 90-alpha A4

2

1

High-throughput

0.504

High

387772

VWF
von Willebrand factor

1

5

Small-scale

0.501

High

387781

NID1
Nidogen-1

1

7

Small-scale

0.501

High

387789

FBLN1
Fibulin-1

1

8

Small-scale

0.501

High

231368

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

High-throughput

0.489

High

355393

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

High-throughput

0.489

High

387779

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.489

High

387813

DSCR6
Protein ripply3

1

1

High-throughput

0.489

High

387817

SSBP2
Single-stranded DNA-binding protein 2

1

4

High-throughput

0.489

High

387818

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.489

High

387841

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

387844

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

High-throughput

0.489

High

387850

HDGR2
Hepatoma-derived growth factor-related protein 2

1

2

High-throughput

0.489

High

387851

CIR1
Corepressor interacting with RBPJ 1

1

2

High-throughput

0.489

High

387867

PIGT
GPI-anchor transamidase component PIGT

1

1

High-throughput

0.489

High

387876

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

1

High-throughput

0.489

High

387896

CP343
Cytochrome P450 3A43

1

1

High-throughput

0.489

High

387902

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.489

High

387914

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

387923

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.489

High

387927

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.489

High

387831

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.486

High

387816

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.481

High

369287

A1AT
Alpha-1-antitrypsin

1

2

High-throughput

0.479

High

369419

AACT
Alpha-1-antichymotrypsin

1

2

High-throughput

0.479

High

369570

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.479

High

387767

VTDB
Vitamin D-binding protein

1

2

High-throughput

0.479

High

387768

TRFE
Serotransferrin

1

3

High-throughput

0.479

High

387769

HEMO
Hemopexin

1

2

High-throughput

0.479

High

387777

CLUS
Clusterin

1

1

High-throughput

0.479

High

387803

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

2

High-throughput

0.479

High

387888

TRI31
E3 ubiquitin-protein ligase TRIM31

1

5

High-throughput

0.479

High

387909

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

8

Small-scale

0.479

High

387891

MIS12
Protein MIS12 homolog

1

1

High-throughput

0.470

High

387802

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

High-throughput

0.464

High

387839

SMN
Survival motor neuron protein

1

1

High-throughput

0.464

High

387863

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

1

High-throughput

0.464

High

319274

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

361513

CERU
Ceruloplasmin

1

0

High-throughput

0.458

High

387766

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

387770

STAT
Statherin

1

0

High-throughput

0.458

High

387838

PROL4
Proline-rich protein 4

1

0

High-throughput

0.458

High

219587

B2L11
Bcl-2-like protein 11

1

3

High-throughput

0.445

High

261051

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.445

High

387775

F13B
Coagulation factor XIII B chain

1

5

Small-scale

0.445

High

387825

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

387910

RN181
E3 ubiquitin-protein ligase RNF181

1

1

Small-scale

0.439

High

277237

PITX3
Pituitary homeobox 3

1

5

Small-scale

0.437

High

323075

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.437

High

387807

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.437

High

387829

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.437

High

387845

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

2

High-throughput

0.437

High

387846

FBW10
F-box/WD repeat-containing protein 10

1

4

High-throughput

0.437

High

387857

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

387864

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

387893

ASB7
Ankyrin repeat and SOCS box protein 7

1

3

High-throughput

0.437

High

387897

SP110
Sp110 nuclear body protein

1

3

High-throughput

0.437

High

387907

ASB6
Ankyrin repeat and SOCS box protein 6

1

3

High-throughput

0.437

High

387911

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

387879

THIOM
Thioredoxin, mitochondrial

1

5

High-throughput

0.417

High

104714

F6XY72
nucleoside-diphosphate kinase

1

3

High-throughput

0.407

High

387847

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.407

High

142175

PIR
Pirin

2

0

High-throughput

0.328

High

211470

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

2

0

High-throughput

0.328

High

220668

DENR
Density-regulated protein

2

0

High-throughput

0.328

High

281704

VP26A
Vacuolar protein sorting-associated protein 26A

2

0

High-throughput

0.328

High

295272

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

High-throughput

0.328

High

329199

LETM1
Mitochondrial proton/calcium exchanger protein

2

0

High-throughput

0.328

High

387804

FEN1
Flap endonuclease 1

2

0

High-throughput

0.328

High

387815

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

High-throughput

0.328

High

387820

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

2

0

High-throughput

0.328

High

387836

SF3A1
Splicing factor 3A subunit 1

2

0

High-throughput

0.328

High

387859

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

2

0

High-throughput

0.328

High

387861

LZIC
Protein LZIC

2

0

High-throughput

0.328

High

387874

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

2

0

High-throughput

0.328

High

387882

VRK1
Serine/threonine-protein kinase VRK1

2

0

High-throughput

0.328

High

387883

PYM1
Partner of Y14 and mago

2

0

High-throughput

0.328

High

387886

ITPA
Inosine triphosphate pyrophosphatase

2

0

High-throughput

0.328

High

387889

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.328

High

387895

ARMT1
Damage-control phosphatase ARMT1

2

0

High-throughput

0.328

High

387899

UBE2T
Ubiquitin-conjugating enzyme E2 T

2

0

High-throughput

0.328

High

387905

RBM12
RNA-binding protein 12

2

0

High-throughput

0.328

High

387906

PNPO
Pyridoxine-5'-phosphate oxidase

2

0

High-throughput

0.328

High

387918

MCTS1
Malignant T-cell-amplified sequence 1

2

0

High-throughput

0.328

High

387922

RRP44
Exosome complex exonuclease RRP44

2

0

High-throughput

0.328

High

387925

SBDS
Ribosome maturation protein SBDS

2

0

High-throughput

0.328

High

177987

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

0

High-throughput

0.279

Low

387790

TCEA1
Transcription elongation factor A protein 1

1

0

High-throughput

0.279

Low

387796

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.279

Low

387799

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.279

Low

387809

PAPOA
Poly(A) polymerase alpha

1

0

High-throughput

0.279

Low

387810

DUS3
Dual specificity protein phosphatase 3

1

0

High-throughput

0.279

Low

387828

SCRN1
Secernin-1

1

0

High-throughput

0.279

Low

387853

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.279

Low

387870

K1143
Uncharacterized protein KIAA1143

1

0

High-throughput

0.279

Low

387873

BT3L4
Transcription factor BTF3 homolog 4

1

0

High-throughput

0.279

Low

387877

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

387894

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

High-throughput

0.279

Low

387903

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.279

Low

387904

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.279

Low

387908

HPF1
Histone PARylation factor 1

1

0

High-throughput

0.279

Low

387913

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.279

Low

300873

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.269

Low

387771

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.265

Low

387806

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

387848

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025