HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	23443559
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~P53
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 2610
+	Hs
		386980 P53_HUMAN (1-393): 0: 619: 100.00		HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66
+	Hs
		387650 P53_HUMAN (1-393): 0: 619: 100.00		HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40
+	Hs
		303994 P53_HUMAN (1-393): 0: 619: 100.00		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		387302 P53_HUMAN (1-393): 0: 619: 100.00		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		387553 P53_HUMAN (1-393): 0: 619: 100.00		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125079 P53_HUMAN (1-393): 0: 619: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		387482 P53_HUMAN (1-393): 0: 619: 100.00		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		175932 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40
+	Hs
		175909 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		125008 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		1294857 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		175923 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		1327910 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		386580 P53_HUMAN (1-393): 0: 619: 100.00		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		386782 P53_HUMAN (1-393): 0: 619: 100.00		UBE3C_HUMAN (2405-2610): 9.09e-23: 109: 32.37
+	Mm
		356871 P53_MOUSE (1-393): 0: 589: 77.35		HUWE1_MOUSE (2405-2609): 1.01e-18: 96.7: 33.33