HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: ACTN2 (P35609)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	25277244
Identification Methods	two hybrid, reverse ras recruitment system
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005925 - focal adhesion GO:0030018 - Z disc GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 894
+	Hs
		388189 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		ACTN1_HUMAN (8-894): 0: 658: 79.48
+	Hs
		211460 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		ACTN4_HUMAN (18-894): 0: 619: 77.89
+	Mm
		1186643 HSPB2_MOUSE (1-181): 3.51e-43: 144: 33.88		ACTN1_MOUSE (8-894): 0: 655: 79.26
+	Hs
		725711 HSPB8_HUMAN (1-180): 1.08e-42: 143: 37.17		ACTN2_HUMAN (1-894): 0: 652: 100.00
+	Dm
		113825 M9NHC5_DROME (72-185): 1.69e-31: 113: 33.33		ACTN_DROME (8-894): 0: 621: 66.34
+	Hs
		388383 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		SPTB2_HUMAN (232-802): 2.32e-09: 63.5: 9.98
+	Mm
		1143725 HSPB2_MOUSE (1-181): 3.51e-43: 144: 33.88		SPTB2_MOUSE (232-802): 1.8e-09: 63.9: 9.98
+	Ce
		110563 Q86GU1_CAEEL (47-176): 1.43e-34: 123: 34.59		H2L2C8_CAEEL (207-893): 1.76e-11: 70.1: 14.12