Protein: TNPO2
Transportin-2 (Karyopherin beta-2b)

Gene: TNPO2
Organism: Homo sapiens
Interactions: 195
UniProt ID: O14787

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006606 - protein import into nucleus
GO:0008139 - nuclear localization sequence binding
GO:0031267 - small GTPase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

164559

RAN
GTP-binding nuclear protein Ran

4

19

Small-scale

0.897

High

164576

IMB1
Importin subunit beta-1

1

10

High-throughput

0.691

High

164623

TMA16
Translation machinery-associated protein 16

3

2

High-throughput

0.667

High

164495

XRP2
Protein XRP2

3

4

High-throughput

0.656

High

164579

MICA
MHC class I polypeptide-related sequence A

3

1

High-throughput

0.656

High

164666

TN13B
Tumor necrosis factor ligand superfamily member 13B

3

7

High-throughput

0.656

High

164498

KLHL2
Kelch-like protein 2

2

2

High-throughput

0.628

High

164571

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

3

High-throughput

0.628

High

164658

NXF1
Nuclear RNA export factor 1

2

6

Small-scale

0.624

High

164540

CD68
Macrosialin

4

2

High-throughput

0.623

High

164510

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.618

High

164515

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

9

High-throughput

0.618

High

164572

CUL3
Cullin-3

1

9

High-throughput

0.618

High

164619

TNPO1
Transportin-1

1

10

High-throughput

0.618

High

164660

XPO7
Exportin-7

1

7

High-throughput

0.618

High

137148

EXOC5
Exocyst complex component 5

2

0

High-throughput

0.613

High

164664

FZD10
Frizzled-10

2

6

High-throughput

0.611

High

164670

RNF11
RING finger protein 11

2

4

High-throughput

0.611

High

164490

GSC2
Homeobox protein goosecoid-2

2

2

High-throughput

0.606

High

164535

GCH1
GTP cyclohydrolase 1

2

1

High-throughput

0.606

High

164561

PO6F2
POU domain, class 6, transcription factor 2

2

5

High-throughput

0.606

High

164569

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

2

3

High-throughput

0.606

High

164570

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

2

3

High-throughput

0.606

High

164578

SF01
Splicing factor 1

2

3

High-throughput

0.606

High

164602

RBM45
RNA-binding protein 45

2

8

High-throughput

0.606

High

164622

BIRC7
Baculoviral IAP repeat-containing protein 7

2

8

High-throughput

0.606

High

164635

TRIM8
E3 ubiquitin-protein ligase TRIM8

2

6

High-throughput

0.606

High

164648

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

1

High-throughput

0.606

High

164659

KLHL3
Kelch-like protein 3

2

2

High-throughput

0.606

High

164624

MTNB
Methylthioribulose-1-phosphate dehydratase

2

0

High-throughput

0.601

High

164493

SCN2B
Sodium channel regulatory subunit beta-2

3

14

High-throughput

0.599

High

164499

LYPD3
Ly6/PLAUR domain-containing protein 3

3

1

High-throughput

0.599

High

164597

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

8

High-throughput

0.599

High

164603

TARG1
Trafficking regulator of GLUT4 1

3

2

High-throughput

0.599

High

164626

VSIG2
V-set and immunoglobulin domain-containing protein 2

3

8

High-throughput

0.599

High

164655

PD1L1
Programmed cell death 1 ligand 1

3

19

High-throughput

0.599

High

164665

CAH14
Carbonic anhydrase 14

3

8

High-throughput

0.599

High

164600

VSIG1
V-set and immunoglobulin domain-containing protein 1

3

9

High-throughput

0.593

High

164607

SIGL1
SIGLEC family-like protein 1

3

7

High-throughput

0.593

High

164505

EGFR
Epidermal growth factor receptor

2

11

Small-scale

0.584

High

164605

PNKD
Probable thioesterase PNKD

2

4

High-throughput

0.584

High

164644

WDR76
WD repeat-containing protein 76

2

9

High-throughput

0.584

High

164512

FUMH
Fumarate hydratase, mitochondrial

2

0

High-throughput

0.580

High

164536

OTX2
Homeobox protein OTX2

2

0

High-throughput

0.580

High

164560

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.580

High

164566

TBX2
T-box transcription factor TBX2

2

0

High-throughput

0.580

High

164573

BLMH
Bleomycin hydrolase

2

0

High-throughput

0.580

High

164636

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.580

High

164661

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.580

High

164663

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

2

0

High-throughput

0.580

High

164552

TERF1
Telomeric repeat-binding factor 1

1

3

High-throughput

0.573

High

164519

NDKA
Nucleoside diphosphate kinase A

1

2

High-throughput

0.573

High

164629

PNMA5
Paraneoplastic antigen-like protein 5

1

5

High-throughput

0.573

High

164517

TAU
Microtubule-associated protein tau

2

11

High-throughput

0.571

High

60688

F234B
Protein FAM234B

2

5

High-throughput

0.558

High

164511

GLPB
Glycophorin-B

2

4

High-throughput

0.558

High

164513

ACM4
Muscarinic acetylcholine receptor M4

2

9

High-throughput

0.558

High

164520

CD44
CD44 antigen

2

1

High-throughput

0.558

High

164526

EPHA1
Ephrin type-A receptor 1

2

5

High-throughput

0.558

High

164529

EDNRB
Endothelin receptor type B

2

3

High-throughput

0.558

High

164533

5HT2C
5-hydroxytryptamine receptor 2C

2

7

High-throughput

0.558

High

164549

BCAM
Basal cell adhesion molecule

2

2

High-throughput

0.558

High

164556

FCGRN
IgG receptor FcRn large subunit p51

2

1

High-throughput

0.558

High

164563

CD83
CD83 antigen

2

1

High-throughput

0.558

High

164587

VASN
Vasorin

2

3

High-throughput

0.558

High

164589

TM108
Transmembrane protein 108

2

1

High-throughput

0.558

High

164591

DLK2
Protein delta homolog 2

2

5

High-throughput

0.558

High

164611

F174A
Membrane protein FAM174A

2

5

High-throughput

0.558

High

164643

PACC1
Proton-activated chloride channel

2

6

High-throughput

0.558

High

164645

LRRC4
Leucine-rich repeat-containing protein 4

2

3

High-throughput

0.558

High

164502

K2C75
Keratin, type II cytoskeletal 75

2

1

High-throughput

0.553

High

164650

PDLI7
PDZ and LIM domain protein 7

2

3

High-throughput

0.553

High

164651

ANM8
Protein arginine N-methyltransferase 8

2

1

High-throughput

0.553

High

164531

TNR5
Tumor necrosis factor receptor superfamily member 5

2

14

High-throughput

0.549

High

164672

NPTN
Neuroplastin

2

12

High-throughput

0.549

High

164501

SIX3
Homeobox protein SIX3

1

1

High-throughput

0.536

High

164516

TACD2
Tumor-associated calcium signal transducer 2

1

2

High-throughput

0.536

High

164524

S1PR1
Sphingosine 1-phosphate receptor 1

1

7

High-throughput

0.536

High

164545

RANG
Ran-specific GTPase-activating protein

1

20

High-throughput

0.536

High

164548

NU153
Nuclear pore complex protein Nup153

1

20

High-throughput

0.536

High

164562

EFNB1
Ephrin-B1

1

7

High-throughput

0.536

High

164577

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.536

High

164608

SERB1
SERPINE1 mRNA-binding protein 1

1

6

High-throughput

0.536

High

164614

AQP3
Aquaporin-3

1

5

High-throughput

0.536

High

164632

OVOL2
Transcription factor Ovo-like 2

1

20

High-throughput

0.536

High

164612

MO2R1
Cell surface glycoprotein CD200 receptor 1

2

2

High-throughput

0.521

High

164525

5NTD
5'-nucleotidase

1

0

High-throughput

0.517

High

164494

TP4A3
Protein tyrosine phosphatase type IVA 3

1

20

High-throughput

0.515

High

164617

KLK6
Kallikrein-6

1

4

High-throughput

0.515

High

164674

V9HW27
Alpha-crystallin B chain

1

2

High-throughput

0.515

High

164514

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.513

High

164518

PVR
Poliovirus receptor

1

0

High-throughput

0.513

High

164598

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

164625

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.513

High

164542

RL4
Large ribosomal subunit protein uL4

1

5

Small-scale

0.501

High

164551

NUP98
Nuclear pore complex protein Nup98-Nup96

1

20

Small-scale

0.501

High

164647

A1CF
APOBEC1 complementation factor

1

4

Small-scale

0.501

High

133215

P2Y10
Putative P2Y purinoceptor 10

1

20

High-throughput

0.489

High

164491

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.489

High

164497

VAMP5
Vesicle-associated membrane protein 5

1

2

High-throughput

0.489

High

164500

MPZL1
Myelin protein zero-like protein 1

1

14

High-throughput

0.489

High

164508

GLPA
Glycophorin-A

1

4

High-throughput

0.489

High

164527

DRD4
D(4) dopamine receptor

1

9

High-throughput

0.489

High

164534

V2R
Vasopressin V2 receptor

1

8

High-throughput

0.489

High

164538

CD70
CD70 antigen

1

2

High-throughput

0.489

High

164539

CD80
T-lymphocyte activation antigen CD80

1

19

High-throughput

0.489

High

164541

BASI
Basigin

1

13

High-throughput

0.489

High

164543

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

2

High-throughput

0.489

High

164550

EFNA4
Ephrin-A4

1

7

High-throughput

0.489

High

164553

ARSF
Arylsulfatase F

1

2

High-throughput

0.489

High

164555

PAR2
Proteinase-activated receptor 2

1

11

High-throughput

0.489

High

164568

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

18

High-throughput

0.489

High

164574

MAP7
Ensconsin

1

11

High-throughput

0.489

High

164575

FXYD3
FXYD domain-containing ion transport regulator 3

1

2

High-throughput

0.489

High

164590

BTNL9
Butyrophilin-like protein 9

1

4

High-throughput

0.489

High

164595

ARMX6
Protein ARMCX6

1

4

High-throughput

0.489

High

164628

OPALI
Opalin

1

2

High-throughput

0.489

High

164631

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

5

High-throughput

0.489

High

164638

FXYD6
FXYD domain-containing ion transport regulator 6

1

2

High-throughput

0.489

High

164639

F234A
Protein FAM234A

1

5

High-throughput

0.489

High

164640

UN93B
Protein unc-93 homolog B1

1

7

High-throughput

0.489

High

164649

GPR84
G-protein coupled receptor 84

1

12

High-throughput

0.489

High

164656

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.489

High

164662

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.489

High

164671

GPR45
Probable G-protein coupled receptor 45

1

11

High-throughput

0.489

High

164507

CRYAB
Alpha-crystallin B chain

1

2

High-throughput

0.481

High

164627

BIRC8
Baculoviral IAP repeat-containing protein 8

1

8

High-throughput

0.481

High

164668

KLH20
Kelch-like protein 20

1

3

High-throughput

0.481

High

164669

ZBT32
Zinc finger and BTB domain-containing protein 32

1

20

High-throughput

0.481

High

164528

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

10

High-throughput

0.479

High

164530

BRD2
Bromodomain-containing protein 2

1

13

High-throughput

0.479

High

164532

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

164558

H4
Histone H4

1

5

High-throughput

0.479

High

164564

KIF23
Kinesin-like protein KIF23

1

10

High-throughput

0.479

High

164565

STK3
Serine/threonine-protein kinase 3

1

5

Small-scale

0.479

High

164567

G3BP1
Ras GTPase-activating protein-binding protein 1

1

7

High-throughput

0.479

High

164584

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

164592

DPPA3
Developmental pluripotency-associated protein 3

1

2

High-throughput

0.479

High

164594

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

164615

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

164618

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

164642

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.479

High

164653

TLS1
Splicing factor C9orf78

1

6

High-throughput

0.479

High

164667

R3HD2
R3H domain-containing protein 2

1

2

High-throughput

0.479

High

164673

NEMO
NF-kappa-B essential modulator

1

2

Small-scale

0.479

High

2881

A0A0C4DGF1
Zinc finger and BTB domain containing 32

1

1

High-throughput

0.470

High

164633

Q9BS75
Kelch-like protein 20

1

3

High-throughput

0.470

High

164489

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

164523

TAL1
T-cell acute lymphocytic leukemia protein 1

1

0

High-throughput

0.458

High

164583

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

164654

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.458

High

164557

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.457

High

164503

PTBP3
Polypyrimidine tract-binding protein 3

1

4

High-throughput

0.445

High

164554

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

164582

CD158
Coiled-coil domain-containing protein 158

1

1

High-throughput

0.439

High

164641

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.439

High

132782

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

0

High-throughput

0.438

High

156691

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.437

High

164170

NRP1
Neuropilin-1

1

2

High-throughput

0.437

High

164509

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

164544

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

8

High-throughput

0.437

High

164546

LPAR6
Lysophosphatidic acid receptor 6

1

18

High-throughput

0.437

High

164580

AR13B
ADP-ribosylation factor-like protein 13B

1

3

High-throughput

0.437

High

164585

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.437

High

164586

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

10

High-throughput

0.437

High

164609

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

10

High-throughput

0.437

High

164613

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

164616

LAR4B
La-related protein 4B

1

2

High-throughput

0.437

High

164646

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

5

High-throughput

0.437

High

164652

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

Small-scale

0.437

High

164547

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

164488

S27A2
Long-chain fatty acid transport protein 2

1

20

High-throughput

0.407

High

164537

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

2

0

High-throughput

0.316

High

164581

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

164599

RDIC1
Regulator of DNA class I crossover intermediates 1

2

0

High-throughput

0.316

High

164601

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

164606

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

164610

THAP6
THAP domain-containing protein 6

2

0

High-throughput

0.316

High

164621

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

2

0

High-throughput

0.316

High

164634

FUCO2
Plasma alpha-L-fucosidase

2

0

High-throughput

0.316

High

164588

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.299

High

71181

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

164492

SNG1
Synaptogyrin-1

1

0

High-throughput

0.279

Low

164496

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.279

Low

164506

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

164521

LEUK
Leukosialin

1

0

High-throughput

0.279

Low

164522

DPEP1
Dipeptidase 1

1

0

High-throughput

0.279

Low

164604

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

164620

P2RX5
P2X purinoceptor 5

1

0

High-throughput

0.279

Low

164630

TR13C
Tumor necrosis factor receptor superfamily member 13C

1

0

High-throughput

0.279

Low

164637

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

164657

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

164593

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.249

Low

164504

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.238

Low

164596

OSTA
Organic solute transporter subunit alpha

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025