Interactor 1: TFR1 (P02786)
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Gene: TFRC
Interactor 2: TRFE (P02787)
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)
Gene: TF
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.973 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11027676, 21788477, 20404192, 14691533, 16271884, 9546397, 29302006, 16354665 |
| Identification Methods | pull down, x-ray crystallography, mass spectrometry studies of complexes, surface plasmon resonance, electron paramagnetic resonance, molecular sieving, classical fluorescence spectroscopy, cosedimentation in solution, fluorescence-activated cell sorting |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PA~Transferrin, TFR_dimer~Transferrin |
| Common GO terms | GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005769 - early endosome GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit and 13 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
