Protein: TRFE
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)

Gene: TRFE, TF
Organism: Homo sapiens
Interactions: 190
UniProt ID: P02787

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005769 - early endosome
GO:0005770 - late endosome
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

390406

TFR1
Transferrin receptor protein 1

8

1

Small-scale

0.973

High

390836

TRFL
Lactotransferrin

2

1

High-throughput

0.754

High

390860

IBP3
Insulin-like growth factor-binding protein 3

1

0

Small-scale

0.687

High

183378

MATN3
Matrilin-3

3

1

High-throughput

0.667

High

390946

SYT17
Synaptotagmin-17

3

1

High-throughput

0.667

High

390970

TFR2
Transferrin receptor protein 2

1

1

Small-scale

0.647

High

390843

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

390864

GLRA2
Glycine receptor subunit alpha-2

3

0

High-throughput

0.638

High

390918

GDPD1
Lysophospholipase D GDPD1

3

0

High-throughput

0.638

High

390915

S38A6
Solute carrier family 38 member 6

3

0

High-throughput

0.634

High

390935

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

390835

TRFE
Serotransferrin

1

1

High-throughput

0.618

High

229861

EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3

2

2

High-throughput

0.611

High

370878

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.611

High

390968

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

390955

SH24A
SH2 domain-containing protein 4A

3

1

High-throughput

0.609

High

211903

SPIT1
Kunitz-type protease inhibitor 1

2

1

High-throughput

0.606

High

390919

SYT2
Synaptotagmin-2

2

1

High-throughput

0.606

High

390878

CD81
CD81 antigen

2

1

Small-scale

0.601

High

390859

LEG3
Galectin-3

2

0

Small-scale

0.585

High

138550

CLD5
Claudin-5

2

0

High-throughput

0.580

High

181226

PGRC2
Membrane-associated progesterone receptor component 2

2

0

High-throughput

0.580

High

213673

AQP9
Aquaporin-9

2

0

High-throughput

0.580

High

390898

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

390899

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.580

High

390910

CPLX4
Complexin-4

2

0

High-throughput

0.580

High

390920

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.580

High

390923

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.580

High

390942

SORT
Sortilin

2

0

High-throughput

0.580

High

390950

S26A6
Solute carrier family 26 member 6

2

0

High-throughput

0.580

High

390956

DDX31
ATP-dependent DNA helicase DDX31

2

2

High-throughput

0.574

High

390849

CXB1
Gap junction beta-1 protein

2

3

High-throughput

0.553

High

390952

ELOV4
Very long chain fatty acid elongase 4

2

1

High-throughput

0.553

High

390850

TAU
Microtubule-associated protein tau

2

1

Small-scale

0.552

High

387193

APOA1
Apolipoprotein A-I

2

0

High-throughput

0.547

High

388870

FINC
Fibronectin

2

0

Small-scale

0.547

High

378754

KVD40
Immunoglobulin kappa variable 2D-40

1

0

High-throughput

0.546

High

132979

MATN2
Matrilin-2

1

2

High-throughput

0.536

High

210667

KLK10
Kallikrein-10

1

4

High-throughput

0.536

High

390839

ESR1
Estrogen receptor

1

1

High-throughput

0.536

High

390852

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

390858

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

390870

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

390900

FNDC1
Fibronectin type III domain-containing protein 1

1

1

High-throughput

0.536

High

390924

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

390938

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

390944

EGFL8
Epidermal growth factor-like protein 8

1

2

High-throughput

0.536

High

390967

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

377845

GAST
Gastrin [Cleaved into: Gastrin-71

1

0

Small-scale

0.531

High

390855

DRD2
D(2) dopamine receptor

1

0

High-throughput

0.518

High

193383

GPR42
G-protein coupled receptor 42

1

2

High-throughput

0.515

High

194451

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

231372

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.513

High

254722

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.513

High

351644

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

390876

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

390914

NRSN1
Neurensin-1

1

0

High-throughput

0.513

High

390921

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

0

High-throughput

0.513

High

390928

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.513

High

390929

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

390949

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

390963

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.513

High

377808

IGF2
Insulin-like growth factor 2

1

1

Small-scale

0.501

High

390842

IGF1
Insulin-like growth factor 1

1

1

Small-scale

0.501

High

390866

CALR
Calreticulin

1

2

Small-scale

0.501

High

390867

CALX
Calnexin

1

2

Small-scale

0.501

High

390848

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

3

High-throughput

0.500

High

318186

DDHD2
Triacylglycerol hydrolase DDHD2

1

1

High-throughput

0.489

High

335223

CXB5
Gap junction beta-5 protein

1

3

High-throughput

0.489

High

390875

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

2

High-throughput

0.489

High

390905

SFXN4
Sideroflexin-4

1

2

High-throughput

0.489

High

390922

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.489

High

390926

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.489

High

390930

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

390933

SMIM8
Small integral membrane protein 8

1

1

High-throughput

0.489

High

390936

ZN558
Zinc finger protein 558

1

1

High-throughput

0.489

High

390943

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

390972

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

390881

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.486

High

390891

TBB3
Tubulin beta-3 chain

1

2

High-throughput

0.481

High

390976

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

1

High-throughput

0.481

High

390977

LAMC3
Laminin subunit gamma-3

1

1

High-throughput

0.481

High

390847

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.480

High

253267

JAK2
Tyrosine-protein kinase JAK2

1

2

High-throughput

0.479

High

361516

CERU
Ceruloplasmin

1

1

High-throughput

0.479

High

366143

HPT
Haptoglobin

1

1

High-throughput

0.479

High

369291

A1AT
Alpha-1-antitrypsin

1

2

High-throughput

0.479

High

369422

AACT
Alpha-1-antichymotrypsin

1

2

High-throughput

0.479

High

387768

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

3

High-throughput

0.479

High

387931

FIBG
Fibrinogen gamma chain

1

3

High-throughput

0.479

High

390266

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.479

High

390851

CLUS
Clusterin

1

1

High-throughput

0.479

High

390853

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.479

High

390856

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

390863

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

4

High-throughput

0.479

High

390868

LCN1
Lipocalin-1

1

1

High-throughput

0.479

High

390869

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.479

High

390882

HBB
Hemoglobin subunit beta

1

2

High-throughput

0.479

High

390904

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.479

High

390961

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

390962

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

390974

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

Small-scale

0.479

High

390975

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

390885

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.460

High

390901

F209A
Protein FAM209A

1

0

High-throughput

0.460

High

390945

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

369799

CO3
Complement C3

1

0

High-throughput

0.458

High

387498

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.458

High

389638

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

390837

HEMO
Hemopexin

1

0

High-throughput

0.458

High

390838

STAT
Statherin

1

0

High-throughput

0.458

High

390857

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

390865

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

390894

PROL4
Proline-rich protein 4

1

0

High-throughput

0.458

High

390896

HFE
Hereditary hemochromatosis protein

1

0

Small-scale

0.458

High

390841

TBB4A
Tubulin beta-4A chain

1

2

High-throughput

0.457

High

229258

ANGL7
Angiopoietin-related protein 7

1

3

High-throughput

0.445

High

379062

IGKC
Immunoglobulin kappa constant

1

1

High-throughput

0.445

High

379184

IGHG1
Immunoglobulin heavy constant gamma 1

1

3

High-throughput

0.445

High

379602

IGHA1
Immunoglobulin heavy constant alpha 1

1

3

High-throughput

0.445

High

389911

ALBU
Albumin

1

1

High-throughput

0.445

High

390845

HEP2
Heparin cofactor 2

1

2

High-throughput

0.445

High

390862

RYR1
Ryanodine receptor 1

1

1

High-throughput

0.445

High

390892

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

390927

RENT1
Regulator of nonsense transcripts 1

1

1

High-throughput

0.445

High

390973

PRG3
Proteoglycan 3

1

2

High-throughput

0.445

High

105084

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

390840

GCR
Glucocorticoid receptor

1

1

Small-scale

0.437

High

390890

SP140
Nuclear body protein SP140

1

3

High-throughput

0.437

High

390907

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

390951

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.437

High

261054

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

389776

TTHY
Transthyretin

1

0

High-throughput

0.426

High

390844

F13B
Coagulation factor XIII B chain

1

0

Small-scale

0.426

High

390846

CATL1
Procathepsin L

1

0

High-throughput

0.426

High

390879

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

390888

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.426

High

390893

K2C72
Keratin, type II cytoskeletal 72

1

0

High-throughput

0.426

High

390954

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.426

High

390903

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

390908

SETX
Probable helicase senataxin

1

1

High-throughput

0.407

High

390871

CAH8
Carbonic anhydrase-related protein

3

0

High-throughput

0.347

High

390916

STPG2
Sperm-tail PG-rich repeat-containing protein 2

3

0

High-throughput

0.347

High

390959

SAS10
Something about silencing protein 10

3

0

High-throughput

0.347

High

390895

MK06
Mitogen-activated protein kinase 6

2

0

High-throughput

0.328

High

390917

CCD82
Coiled-coil domain-containing protein 82

2

0

High-throughput

0.328

High

71833

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

0

High-throughput

0.316

High

390909

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.316

High

390934

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.316

High

390939

RMD3
Regulator of microtubule dynamics protein 3

2

0

High-throughput

0.316

High

390971

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.316

High

390925

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.282

High

390932

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

355396

NSD2
Histone-lysine N-methyltransferase NSD2

1

0

High-throughput

0.279

Low

390861

CCNA2
Cyclin-A2

1

0

High-throughput

0.279

Low

390873

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

390877

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

390884

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.279

Low

390886

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.279

Low

390887

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.279

Low

390897

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

390902

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

0

High-throughput

0.279

Low

390911

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

390912

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.279

Low

390937

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

0

High-throughput

0.279

Low

390960

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.279

Low

390966

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

390953

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.269

Low

390947

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.261

Low

390958

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.251

Low

390969

TIM
Protein timeless homolog

1

0

High-throughput

0.251

Low

360704

COX3
Cytochrome c oxidase subunit 3

1

0

Small-scale

0.249

Low

390854

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.249

Low

390872

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

390874

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

390880

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

390889

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.249

Low

390906

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

390931

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.249

Low

390941

EYA1
Protein phosphatase EYA1

1

0

High-throughput

0.249

Low

390957

NGB
Neuroglobin

1

0

High-throughput

0.249

Low

390964

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

390965

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.249

Low

390883

3BP2
SH3 domain-binding protein 2

1

0

High-throughput

0.238

Low

219590

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.232

Low

344056

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

390913

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

390940

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low

390948

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025