HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: CNR1 (P21554)
Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)
Gene: CNR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11168387
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007584 - response to nutrient
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 472
+	Hs
		599336 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		CNR1_HUMAN (1-472): 1.31e-117: 354: 100.00
+	Hs
		444665 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		CNR1_HUMAN (1-472): 1.31e-117: 354: 100.00
+	Hs
		598724 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		S1PR1_HUMAN (120-416): 1.02e-79: 254: 28.76
+	Hs
		444664 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		S1PR1_HUMAN (120-416): 1.02e-79: 254: 28.76
+	Hs
		391305 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77
+	Hs
		429011 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77
+	Hs
		391347 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		OPRD_HUMAN (64-443): 1.38e-67: 222: 15.84
+	Hs
		428884 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77
+	Hs
		598719 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		S1PR1_HUMAN (120-416): 1.02e-79: 254: 28.76
+	Hs
		450984 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRD_HUMAN (64-443): 1.38e-67: 222: 15.84
+	Hs
		450979 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRM_HUMAN (67-452): 1.36e-64: 215: 14.76
+	Hs
		428911 GNAT2_HUMAN (1-355): 1.04e-166: 470: 69.86		ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77
+	Hs
		304718 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		S1PR2_HUMAN (85-414): 7.16e-72: 233: 26.21
+	Hs
		598736 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		S1PR1_HUMAN (120-416): 1.02e-79: 254: 28.76
+	Hs
		580402 GNAZ_HUMAN (1-354): 6.56e-160: 453: 66.38		DRD5_HUMAN (133-421): 3.75e-68: 227: 19.82
+	Hs
		686617 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		CCR1_HUMAN (118-442): 4.1e-64: 213: 15.52
+	Hs
		602214 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		DRD5_HUMAN (133-421): 3.75e-68: 227: 19.82
+	Hs
		429010 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		ADRB2_HUMAN (98-432): 9.49e-71: 231: 19.77
+	Hs
		602211 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		DRD5_HUMAN (133-421): 3.75e-68: 227: 19.82
+	Hs
		686657 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		CCR1_HUMAN (118-442): 4.1e-64: 213: 15.52