Protein: MARK4
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)

Gene: MARK4
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q96L34

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000930 - gamma-tubulin complex
GO:0001578 - microtubule bundle formation
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

692118

MARK3
MAP/microtubule affinity-regulating kinase 3

2

16

High-throughput

0.811

High

835732

KPCI
Protein kinase C iota type

2

11

Small-scale

0.799

High

1154423

STK11
Serine/threonine-protein kinase STK11

1

19

High-throughput

0.715

High

717940

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

9

High-throughput

0.691

High

889177

RBM25
RNA-binding protein 25

1

9

High-throughput

0.691

High

955482

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.691

High

1396675

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

0

Small-scale

0.687

High

1049668

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

463709

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.665

High

877203

KC1D
Casein kinase I isoform delta

1

8

High-throughput

0.665

High

530232

TAU
Microtubule-associated protein tau

3

11

Small-scale

0.655

High

728388

AKT1
RAC-alpha serine/threonine-protein kinase

1

15

Small-scale

0.647

High

1371504

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

4

Small-scale

0.646

High

655891

TBG1
Tubulin gamma-1 chain

2

8

Small-scale

0.635

High

996519

ACTS
Actin, alpha skeletal muscle

1

4

Small-scale

0.618

High

1095439

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

18

Small-scale

0.618

High

1106041

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

4

High-throughput

0.618

High

1270497

MARK2
Serine/threonine-protein kinase MARK2

1

16

High-throughput

0.618

High

1396677

PAR6G
Partitioning defective 6 homolog gamma

1

4

High-throughput

0.618

High

1396681

PAR6A
Partitioning defective 6 homolog alpha

1

8

High-throughput

0.618

High

1396683

PNMA2
Paraneoplastic antigen Ma2

3

8

High-throughput

0.604

High

391409

FRIL
Ferritin light chain

2

2

High-throughput

0.601

High

971885

1433E
14-3-3 protein epsilon

2

20

Small-scale

0.601

High

990611

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.601

High

771209

APJ
Apelin receptor

1

0

High-throughput

0.584

High

1396679

MANS1
MANSC domain-containing protein 1

2

2

High-throughput

0.574

High

1146102

K1H1
Keratin, type I cuticular Ha1

1

4

High-throughput

0.573

High

1203228

ODFP2
Outer dense fiber protein 2

1

12

Small-scale

0.561

High

280781

PR40A
Pre-mRNA-processing factor 40 homolog A

1

8

High-throughput

0.536

High

322858

MTCL2
Microtubule cross-linking factor 2

1

16

High-throughput

0.536

High

457621

TBB5
Tubulin beta chain

1

5

Small-scale

0.536

High

610437

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.536

High

903456

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

3

High-throughput

0.536

High

966752

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

977565

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

9

High-throughput

0.536

High

1144126

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.536

High

1259427

TBA1A
Tubulin alpha-1A chain

1

4

Small-scale

0.536

High

1272195

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

1

High-throughput

0.536

High

1336445

PNMA1
Paraneoplastic antigen Ma1

1

8

High-throughput

0.536

High

1365575

MY18A
Unconventional myosin-XVIIIa

1

13

High-throughput

0.536

High

1371052

ARHG2
Rho guanine nucleotide exchange factor 2

1

5

High-throughput

0.536

High

1371604

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

High-throughput

0.536

High

1396674

DOCK7
Dedicator of cytokinesis protein 7

1

1

High-throughput

0.536

High

1396678

RNF41
E3 ubiquitin-protein ligase NRDP1

1

8

High-throughput

0.536

High

1396684

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1396685

MTCL1
Microtubule cross-linking factor 1

1

16

High-throughput

0.536

High

1396686

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

422899

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.515

High

1279479

KCD20
BTB/POZ domain-containing protein KCTD20

1

0

High-throughput

0.513

High

1396676

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

536354

MTAP2
Microtubule-associated protein 2

1

13

Small-scale

0.501

High

698346

MAP4
Microtubule-associated protein 4

1

11

Small-scale

0.501

High

861729

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

11

High-throughput

0.501

High

1322627

RPTOR
Regulatory-associated protein of mTOR

1

11

Small-scale

0.501

High

880464

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.493

High

190462

COPT1
High affinity copper uptake protein 1

1

3

High-throughput

0.489

High

965828

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

3

High-throughput

0.481

High

1205936

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

11

High-throughput

0.481

High

1230204

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.481

High

1277358

NT2NA
Notch homolog 2 N-terminal-like protein A

1

6

High-throughput

0.481

High

169708

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.480

High

404876

PRIO
Major prion protein

1

0

Small-scale

0.480

High

761823

HSP74
Heat shock 70 kDa protein 4

1

7

Small-scale

0.479

High

772961

MYH9
Myosin-9

1

11

Small-scale

0.479

High

773251

MYH10
Myosin-10

1

11

Small-scale

0.479

High

1115002

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1390206

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

1

High-throughput

0.479

High

1396682

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

9

High-throughput

0.479

High

1055346

APLP2
Amyloid beta precursor like protein 2

1

3

High-throughput

0.470

High

106478

APRIO
Alternative prion protein

1

4

Small-scale

0.457

High

284710

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

1

1

High-throughput

0.439

High

1295650

HPS6
BLOC-2 complex member HPS6

1

0

High-throughput

0.438

High

174586

TRI66
Tripartite motif-containing protein 66

1

7

High-throughput

0.437

High

58903

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.426

High

1396680

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025