HitPredict

Interactor 1: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Interactor 2: ERCC6 (Q03468)
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
Gene: ERCC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	11003660, 30021884
Identification Methods	affinity chromatography technology, proximity labelling technology, far western blotting, cross-linking study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 130 Hs			1 1493
+	Hs
		976461 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		ERCC6_HUMAN (1-1493): 0: 1168: 100.00
+	Hs
		391728 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD9_HUMAN (3-1492): 0: 774: 18.73
+	Hs
		470387 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		391704 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		1059795 H2A1H_HUMAN (1-128): 1.81e-67: 201: 98.44		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		1059717 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		1059647 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		391675 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		1018640 H2A1H_HUMAN (1-128): 1.81e-67: 201: 98.44		CHD3_HUMAN (303-1446): 0: 759: 19.68
+	Hs
		555466 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		CHD4_HUMAN (303-1439): 0: 766: 18.35
+	Hs
		391915 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD8_HUMAN (2-1474): 0: 725: 16.46
+	Hs
		555654 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		CHD8_HUMAN (2-1474): 0: 725: 16.46
+	Hs
		470278 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		SMCA1_HUMAN (369-1372): 0: 700: 20.58
+	Hs
		229279 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		SMCA5_HUMAN (368-1383): 0: 698: 20.75
+	Hs
		229433 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		SMCA5_HUMAN (368-1383): 0: 698: 20.75
+	Hs
		555306 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		SMCA1_HUMAN (369-1372): 0: 700: 20.58
+	Hs
		229296 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		SMCA5_HUMAN (368-1383): 0: 698: 20.75
+	Hs
		151474 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		CHD2_HUMAN (107-1433): 0: 681: 19.17
+	Hs
		555359 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		SMCA4_HUMAN (228-1324): 0: 677: 19.90
+	Hs
		555358 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		SMCA2_HUMAN (228-1247): 0: 660: 19.72