HitPredict

Interactor 1: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	29386386, 33589814
Identification Methods	enzymatic study, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 130 Hs			1 406
+	Hs
		555425 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		1151374 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		1185208 H2A3_HUMAN (1-130): 3.34e-68: 203: 99.23		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		470514 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		391856 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		1216249 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		1087089 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		470285 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		717932 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		391572 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		717876 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		555322 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		391861 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		470533 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		1087090 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		391879 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		391581 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		749544 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Mm
		1145461 H2A2C_MOUSE (1-130): 1.54e-65: 196: 95.39		CHFR_MOUSE (24-278): 1.38e-34: 137: 15.69
+	Hs
		555327 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63