Protein: IL1RA
Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra)

Gene: IL1RA, IL1RN
Organism: Homo sapiens
Interactions: 59
UniProt ID: P18510

Gene Ontology (top 5):
GO:0005125 - cytokine activity
GO:0005149 - interleukin-1 receptor binding
GO:0005150 - interleukin-1, type I receptor binding
GO:0005151 - interleukin-1, type II receptor binding
GO:0005152 - interleukin-1 receptor antagonist activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575743

IL1R1
Interleukin-1 receptor type 1

3

9

Small-scale

0.853

High

615205

IL1R2
Interleukin-1 receptor type 2

2

9

Small-scale

0.754

High

391562

FRIH
Ferritin heavy chain

2

1

High-throughput

0.628

High

615228

CDK15
Cyclin-dependent kinase 15

2

2

High-throughput

0.628

High

615231

SC22C
Vesicle-trafficking protein SEC22c

3

2

High-throughput

0.609

High

615251

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.602

High

615241

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

615244

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.549

High

292544

RENR
Renin receptor

1

2

High-throughput

0.536

High

602728

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

615206

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

615209

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

615212

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.536

High

615236

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.536

High

615240

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.536

High

615243

KLH11
Kelch-like protein 11

1

2

High-throughput

0.536

High

615247

PHF11
PHD finger protein 11

1

2

High-throughput

0.536

High

615253

RN115
E3 ubiquitin-protein ligase RNF115

1

2

High-throughput

0.536

High

615242

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.529

High

615238

BTBD1
BTB/POZ domain-containing protein 1

1

1

High-throughput

0.515

High

615216

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

615220

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.513

High

615224

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

615237

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

615248

CSN3
COP9 signalosome complex subunit 3

1

1

Small-scale

0.501

High

615219

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.493

High

615221

RIFK
Riboflavin kinase

1

0

High-throughput

0.493

High

325278

OR2A4
Olfactory receptor 2A4

1

3

High-throughput

0.489

High

615211

SSBP2
Single-stranded DNA-binding protein 2

1

4

High-throughput

0.489

High

615217

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

615222

PIGT
GPI-anchor transamidase component PIGT

1

2

High-throughput

0.489

High

615226

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.489

High

615230

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

3

High-throughput

0.489

High

615250

SSUH2
Protein SSUH2 homolog

1

3

High-throughput

0.489

High

615233

CSN4
COP9 signalosome complex subunit 4

1

0

Small-scale

0.480

High

615207

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

615214

TF65
Transcription factor p65

1

6

Small-scale

0.479

High

615215

CSN1
COP9 signalosome complex subunit 1

1

0

Small-scale

0.458

High

615252

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

261080

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.445

High

615213

COAA1

1

1

High-throughput

0.445

High

615229

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.445

High

337438

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.426

High

388491

CRP

1

0

High-throughput

0.426

High

554152

BMP4
Bone morphogenetic protein 4

1

0

High-throughput

0.426

High

615223

PSMG2
Proteasome assembly chaperone 2

1

0

High-throughput

0.426

High

615227

OPALI
Opalin

1

0

High-throughput

0.426

High

615239

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.426

High

615245

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.426

High

615249

POMP
Proteasome maturation protein

1

0

High-throughput

0.426

High

615254

SNX11
Sorting nexin-11

1

0

High-throughput

0.426

High

615246

TCAL9
Transcription elongation factor A protein-like 9

1

1

High-throughput

0.407

High

615208

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

615210

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

615232

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.279

Low

615234

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

615218

RWDD4
RWD domain-containing protein 4

1

0

High-throughput

0.232

Low

615225

ZN428
Zinc finger protein 428

1

0

High-throughput

0.232

Low

615235

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025