HitPredict

Interactor 1: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	29386386, 18460542
Identification Methods	enzymatic study, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 130 Hs			1 259
+	Hs
		470533 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00
+	Hs
		470285 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		717932 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		391572 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		717876 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		555322 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		1151374 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1185208 H2A3_HUMAN (1-130): 3.34e-68: 203: 99.23		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		470514 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		391856 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1216249 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1087089 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		555611 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1307111 H2A1J_HUMAN (1-128): 1.18e-67: 201: 97.66		TRI31_HUMAN (32-246): 2.35e-32: 124: 17.27
+	Hs
		391666 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Mm
		1145461 H2A2C_MOUSE (1-130): 1.54e-65: 196: 95.39		CHFR_MOUSE (8-187): 3.69e-31: 123: 17.30
+	Hs
		555425 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		282470 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		RNF8_HUMAN (24-130): 3e-10: 61.7: 28.04
+	Hs
		282668 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		RNF8_HUMAN (24-130): 3e-10: 61.7: 28.04
+	Hs
		282515 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		RNF8_HUMAN (24-130): 3e-10: 61.7: 28.04