Protein: TPIS
Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)

Gene: TPIS, TPI1
Organism: Homo sapiens
Interactions: 189
UniProt ID: P60174

Gene Ontology (top 5):
GO:0004807 - triose-phosphate isomerase activity
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006094 - gluconeogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

949125

TPIS
Triosephosphate isomerase

1

7

Small-scale

0.710

High

241240

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.656

High

361187

SODC
Superoxide dismutase [Cu-Zn]

2

1

High-throughput

0.611

High

563506

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

949214

HYPK
Huntingtin-interacting protein K

2

0

Small-scale

0.585

High

402567

ALDOA
Fructose-bisphosphate aldolase A

2

1

High-throughput

0.584

High

363060

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

353165

AGR2
Anterior gradient protein 2 homolog

2

0

Small-scale

0.576

High

949157

EZH2
Histone-lysine N-methyltransferase EZH2

2

0

High-throughput

0.576

High

934355

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.571

High

949205

DDX24
ATP-dependent RNA helicase DDX24

2

1

High-throughput

0.561

High

400566

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.559

High

830443

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

949202

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

928397

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

486679

FGR
Tyrosine-protein kinase Fgr

2

0

High-throughput

0.547

High

949131

RAC1
Ras-related C3 botulinum toxin substrate 1

2

0

High-throughput

0.547

High

949161

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.547

High

949186

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.547

High

949155

SETB1
Histone-lysine N-methyltransferase SETDB1

1

1

High-throughput

0.541

High

464890

SP1
Transcription factor Sp1

1

0

High-throughput

0.537

High

550947

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.537

High

180762

TIF1A
Transcription intermediary factor 1-alpha

1

3

High-throughput

0.536

High

861539

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

High-throughput

0.536

High

949194

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.536

High

949176

SLX4
Structure-specific endonuclease subunit SLX4

2

1

High-throughput

0.533

High

135567

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

583512

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

High-throughput

0.513

High

640830

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.513

High

787956

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

949156

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

949187

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

949197

ARI3A
AT-rich interactive domain-containing protein 3A

1

0

High-throughput

0.513

High

949209

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

949225

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

949158

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

690869

1433T
14-3-3 protein theta

1

4

High-throughput

0.501

High

949227

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

843434

HD
Huntingtin

1

0

High-throughput

0.493

High

949196

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.489

High

421823

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

302447

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

445799

ENOA
Alpha-enolase

1

4

High-throughput

0.479

High

573412

ENPL
Endoplasmin

1

3

High-throughput

0.479

High

606517

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

640659

ZP3
Zona pellucida sperm-binding protein 3

1

1

Small-scale

0.479

High

660015

COF1
Cofilin-1

1

1

Small-scale

0.479

High

713988

PML
Protein PML

1

3

High-throughput

0.479

High

798913

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

828726

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

861963

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

949128

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.479

High

949130

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

Small-scale

0.479

High

949132

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.479

High

949135

VIGLN
Vigilin

1

1

High-throughput

0.479

High

949138

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.479

High

949139

SOS2
Son of sevenless homolog 2

1

1

High-throughput

0.479

High

949151

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

949165

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

949188

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

949189

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.479

High

949193

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.479

High

949198

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

949201

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

949204

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.479

High

949206

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.479

High

949216

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

949217

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

949221

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.479

High

227451

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

259698

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

272024

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

297533

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.458

High

315349

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319581

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324688

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

371601

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

375331

RASK
GTPase KRas

1

0

High-throughput

0.458

High

411671

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

443037

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

459520

PROF1
Profilin-1

1

0

High-throughput

0.458

High

476125

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

485020

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

533814

MCF2
Proto-oncogene DBL

1

0

High-throughput

0.458

High

542755

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.458

High

553153

KCRB
Creatine kinase B-type

1

0

High-throughput

0.458

High

570866

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

588342

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

623214

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

629696

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

667689

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

681313

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

685475

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.458

High

695072

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

697823

CALR
Calreticulin

1

0

High-throughput

0.458

High

702908

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

715506

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

717423

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.458

High

762282

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

861091

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

868991

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

872128

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

876457

K2C6C
Keratin, type II cytoskeletal 6C

1

0

Small-scale

0.458

High

887885

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

892653

DNLI4
DNA ligase 4

1

0

High-throughput

0.458

High

898418

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

912823

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

926906

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

949126

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

949127

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

949129

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

949133

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

949134

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

949136

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

949140

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

949141

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

949142

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

949144

ILF3
Interleukin enhancer-binding factor 3

1

0

Small-scale

0.458

High

949145

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

949146

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

949147

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

949148

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

949149

CUL1
Cullin-1

1

0

High-throughput

0.458

High

949153

CUL7
Cullin-7

1

0

High-throughput

0.458

High

949154

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

949159

CT451
Cancer/testis antigen family 45 member A1

1

0

High-throughput

0.458

High

949162

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

949163

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

949166

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

949167

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

949168

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

949169

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.458

High

949171

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

949172

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

949177

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

949182

F184A
Protein FAM184A

1

0

High-throughput

0.458

High

949183

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

949185

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

949190

CDCA5
Sororin

1

0

Small-scale

0.458

High

949192

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

949195

NECD
Necdin

1

0

High-throughput

0.458

High

949200

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

949207

SHRPN
Sharpin

1

0

Small-scale

0.458

High

949208

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

949210

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

949211

ANLN
Anillin

1

0

High-throughput

0.458

High

949213

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

949218

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

949219

PRP19
Pre-mRNA-processing factor 19

1

0

High-throughput

0.458

High

949220

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

949223

NINL
Ninein-like protein

1

0

High-throughput

0.458

High

949226

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

327886

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.445

High

765299

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

906846

CCL11
Eotaxin

1

0

High-throughput

0.438

High

949143

ZP4
Zona pellucida sperm-binding protein 4

1

1

Small-scale

0.437

High

949170

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

949174

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

949184

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.437

High

244942

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

529455

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

653228

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

949150

DAG1
Dystroglycan 1

1

0

Small-scale

0.426

High

949164

RNLS
Renalase

1

0

Small-scale

0.426

High

886688

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

949178

RHG24
Rho GTPase-activating protein 24

2

0

High-throughput

0.298

High

949212

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

702755

5HT2C
5-hydroxytryptamine receptor 2C

1

0

High-throughput

0.282

High

719501

BKRB2
B2 bradykinin receptor

1

0

High-throughput

0.282

High

724019

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

773840

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

949199

PYGO2
Pygopus homolog 2

1

0

High-throughput

0.279

Low

105667

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

239783

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

767831

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

949152

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

949160

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.249

Low

949173

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

949179

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

949180

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

949181

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

949191

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

949215

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

949224

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

949222

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

1

0

High-throughput

0.238

Low

949137

P
P protein

1

0

High-throughput

0.232

Low

949175

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low

949203

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025