Protein: TPIS
Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase)

Gene: TPIS, TPI1
Organism: Saccharomyces cerevisiae S288C
Interactions: 143
UniProt ID: P00942

Gene Ontology (top 5):
GO:0004807 - triose-phosphate isomerase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

368366

TPIS
Triosephosphate isomerase

4

7

Small-scale

0.893

High

368411

SIS1
Protein SIS1

4

1

High-throughput

0.678

High

368392

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.624

High

368400

HSC82
ATP-dependent molecular chaperone HSC82

2

3

High-throughput

0.611

High

368456

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

368393

HSP72
Heat shock protein SSA2

2

3

High-throughput

0.571

High

368425

HSP7F
Heat shock protein homolog SSE1

2

3

High-throughput

0.571

High

368471

FAR11
Factor arrest protein 11

2

0

High-throughput

0.563

High

368383

LTE1
Guanine nucleotide exchange factor LTE1

1

1

High-throughput

0.536

High

368405

GAP1
General amino-acid permease GAP1

1

0

Small-scale

0.529

High

368469

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

368476

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

368482

ACL4
Assembly chaperone of RPL4

1

0

High-throughput

0.513

High

368388

NFT1
ABC transporter NFT1

1

1

High-throughput

0.494

High

368470

RHO5
GTP-binding protein RHO5

1

1

Small-scale

0.481

High

368391

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

358921

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.479

High

359097

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

High-throughput

0.479

High

359392

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.479

High

361400

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.479

High

367633

ENO1
Enolase 1

1

4

High-throughput

0.479

High

367833

ENO2
Enolase 2

1

4

High-throughput

0.479

High

368367

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

368369

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.479

High

368377

SC160
Protein SCP160

1

2

High-throughput

0.479

High

368378

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.479

High

368384

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.479

High

368402

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.479

High

368408

HSP74
Heat shock protein SSA4

1

2

High-throughput

0.479

High

368414

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

368422

PYC2
Pyruvate carboxylase 2

1

1

High-throughput

0.479

High

368435

MCM7
DNA replication licensing factor MCM7

1

1

High-throughput

0.479

High

368446

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.479

High

368447

HMF1
Protein HMF1

1

1

High-throughput

0.479

High

368449

MMF1
Protein MMF1, mitochondrial

1

1

High-throughput

0.479

High

368465

VID30
GID complex subunit 1

1

1

High-throughput

0.479

High

368475

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

368479

COFI
Cofilin

1

1

High-throughput

0.479

High

368480

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

368484

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.479

High

360917

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

Small-scale

0.458

High

364847

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

365508

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

368368

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

368370

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

368371

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

368372

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

368373

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

368374

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

368375

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

368376

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

368379

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

368380

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

368381

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

368382

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

368385

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

368386

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

368387

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

368390

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

368395

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

368396

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

368398

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

368399

TAL1
Transaldolase

1

0

High-throughput

0.458

High

368401

STI1
Heat shock protein STI1

1

0

High-throughput

0.458

High

368404

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

0

High-throughput

0.458

High

368406

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.458

High

368407

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

368409

TKT1
Transketolase 1

1

0

High-throughput

0.458

High

368410

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.458

High

368412

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

368413

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.458

High

368415

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

368417

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.458

High

368420

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.458

High

368421

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

368423

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.458

High

368424

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

368427

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

368429

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

368431

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.458

High

368433

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

368434

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.458

High

368437

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

368438

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

368439

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

368440

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

High-throughput

0.458

High

368441

DNPEP
Aspartyl aminopeptidase 4

1

0

High-throughput

0.458

High

368442

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

368444

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

368445

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

368451

TM108
Protein TMA108

1

0

High-throughput

0.458

High

368454

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

368455

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

368457

DUG1
Cys-Gly metallodipeptidase DUG1

1

0

High-throughput

0.458

High

368460

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

368461

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

368462

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

368463

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.458

High

368464

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.458

High

368467

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

368468

SHY1
Cytochrome oxidase assembly protein SHY1

1

0

Small-scale

0.458

High

368472

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

368473

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.458

High

368477

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

368481

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

368487

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.458

High

368489

ZEO1
Protein ZEO1

1

0

High-throughput

0.458

High

368490

SGO1
Shugoshin

1

0

High-throughput

0.458

High

368491

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

368493

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

368494

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

368498

HSP42
Heat shock protein 42

1

0

High-throughput

0.458

High

368394

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

368448

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

368389

YK104
Putative uncharacterized protein YKR104W

1

1

High-throughput

0.439

High

368418

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

368419

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.437

High

368474

ACT
Actin

1

1

Small-scale

0.437

High

368497

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.437

High

368452

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.298

High

368397

BPT1
Bile pigment transporter 1

1

0

High-throughput

0.282

High

368430

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

368488

YO075
Uncharacterized ABC transporter ATP-binding protein/permease YOL075C

1

0

High-throughput

0.282

High

368478

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.251

Low

368403

TPM1
Tropomyosin-1

1

0

Small-scale

0.249

Low

368416

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

368426

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

368428

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

368436

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

368453

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

368459

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

368466

YGL7
Uncharacterized protein YGL117W

1

0

High-throughput

0.249

Low

368483

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low

368485

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

368486

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

368492

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

368495

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

368432

YET1
Endoplasmic reticulum transmembrane protein 1

1

0

High-throughput

0.232

Low

368443

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low

368450

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

368458

YJE9
Uncharacterized protein YJL049W

1

0

High-throughput

0.232

Low

368496

MAM3
Protein MAM3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025