HitPredict

Interactor 1: AT1A1 (P05023)
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1)
Gene: ATP1A1

Interactor 2: AT1B1 (P05026)
Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)
Gene: ATP1B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.963

The method score is based on:

Property Details
Experiments 31732153, 33961781, 30021884, 35271311, 35681168, 21228272, 25012180
Identification Methods affinity chromatography technology, proximity labelling technology, cross-linking study, thermal shift binding, classical fluorescence spectroscopy, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cation_ATPase_C~Na_K-ATPase
Common GO terms GO:0005391 - P-type sodium:potassium-exchanging transporter activity
GO:0005886 - plasma membrane
GO:0005890 - sodium:potassium-exchanging ATPase complex
GO:0006883 - intracellular sodium ion homeostasis
GO:0010248 - establishment or maintenance of transmembrane electrochemical gradient
and 19 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1023
Hs

1 303
+ Mm
+ Oc
+ Ss
+ Hs
+ Gg
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Oc
+ Ss
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024