Protein: MPP10
U3 small nucleolar RNA-associated protein MPP10 (U3 snoRNA-associated protein MPP10) (M phase phosphoprotein 10)

Gene: MPP10
Organism: Saccharomyces cerevisiae S288C
Interactions: 156
UniProt ID: P47083

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

865154

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

7

2

Small-scale

0.968

High

747026

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

5

5

Small-scale

0.940

High

149846

RS9A
Small ribosomal subunit protein uS4A

2

5

Small-scale

0.754

High

678416

PWP2
Periodic tryptophan protein 2

7

5

Small-scale

0.747

High

798256

ENP1
Essential nuclear protein 1

8

2

Small-scale

0.747

High

817592

UTP7
U3 small nucleolar RNA-associated protein 7

7

1

Small-scale

0.747

High

677469

KRR1
KRR1 small subunit processome component

6

1

Small-scale

0.732

High

825534

UTP25
U3 small nucleolar RNA-associated protein 25

5

1

Small-scale

0.729

High

865204

NOP14
Nucleolar complex protein 14

5

1

Small-scale

0.723

High

865191

SAS10
Something about silencing protein 10

5

1

Small-scale

0.723

High

844521

UTP10
U3 small nucleolar RNA-associated protein 10

8

0

Small-scale

0.722

High

865200

NOP58
Nucleolar protein 58

5

2

Small-scale

0.718

High

865179

RRP9
Ribosomal RNA-processing protein 9

5

7

Small-scale

0.716

High

865162

DHR1
Probable ATP-dependent RNA helicase DHR1

8

0

Small-scale

0.709

High

865166

UTP14
U3 small nucleolar RNA-associated protein 14

5

1

Small-scale

0.709

High

865144

UTP22
U3 small nucleolar RNA-associated protein 22

6

0

Small-scale

0.707

High

865180

NOC4
Nucleolar complex protein 4

5

2

Small-scale

0.702

High

865147

UTP8
U3 small nucleolar RNA-associated protein 8

6

0

Small-scale

0.699

High

865156

UTP6
U3 small nucleolar RNA-associated protein 6

5

0

Small-scale

0.698

High

806539

UTP9
U3 small nucleolar RNA-associated protein 9

5

0

Small-scale

0.688

High

865173

UTP21
U3 small nucleolar RNA-associated protein 21

4

6

Small-scale

0.686

High

865188

UTP16
U3 small nucleolar RNA-associated protein 16

4

0

Small-scale

0.670

High

585308

FBRL
rRNA 2'-O-methyltransferase fibrillarin

3

1

Small-scale

0.656

High

865161

UTP5
U3 small nucleolar RNA-associated protein 5

3

2

Small-scale

0.656

High

865163

UTP15
U3 small nucleolar RNA-associated protein 15

3

5

Small-scale

0.656

High

865168

RRP5
rRNA biogenesis protein RRP5

3

1

Small-scale

0.656

High

865183

UTP4
U3 small nucleolar RNA-associated protein 4

3

7

Small-scale

0.656

High

392975

HSP82
ATP-dependent molecular chaperone HSP82

3

2

High-throughput

0.640

High

865159

HAS1
ATP-dependent RNA helicase HAS1

2

3

High-throughput

0.637

High

512528

RS6A
Small ribosomal subunit protein eS6A

3

1

Small-scale

0.633

High

689544

RS7A
Small ribosomal subunit protein eS7A

3

1

Small-scale

0.633

High

823354

UTP18
U3 small nucleolar RNA-associated protein 18

3

0

Small-scale

0.628

High

865182

BFR2
Protein BFR2

2

1

Small-scale

0.621

High

435595

RS9B
Small ribosomal subunit protein uS4B

1

5

Small-scale

0.618

High

779138

DHR2
Probable ATP-dependent RNA helicase DHR2

2

1

Small-scale

0.614

High

758386

UTP11
U3 small nucleolar RNA-associated protein 11

2

1

Small-scale

0.611

High

865157

UTP17
NET1-associated nuclear protein 1

2

7

Small-scale

0.611

High

865172

UTP13
U3 small nucleolar RNA-associated protein 13

2

8

Small-scale

0.611

High

865194

UTP12
U3 small nucleolar RNA-associated protein 12

2

5

Small-scale

0.611

High

865169

FCF1
rRNA-processing protein FCF1

2

1

Small-scale

0.601

High

865175

SGD1
Suppressor of glycerol defect protein 1

2

0

High-throughput

0.588

High

826193

FAF1
Protein FAF1

2

0

Small-scale

0.585

High

865140

NOL10
Ribosome biogenesis protein ENP2

2

0

Small-scale

0.585

High

524411

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.584

High

674709

RS2
Small ribosomal subunit protein uS5

2

2

Small-scale

0.584

High

802877

DBP8
ATP-dependent RNA helicase DBP8

2

2

Small-scale

0.584

High

865149

ESF2
Pre-rRNA-processing protein ESF2

2

1

Small-scale

0.584

High

865189

BMS1
Ribosome biogenesis protein BMS1

2

4

High-throughput

0.584

High

865192

RRP6
Exosome complex exonuclease RRP6

2

3

High-throughput

0.584

High

865137

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.582

High

512106

RS4A
Small ribosomal subunit protein eS4A

1

1

Small-scale

0.575

High

782371

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.575

High

441995

RS14A
Small ribosomal subunit protein uS11A

2

1

Small-scale

0.571

High

754303

DCA13
Protein SOF1

2

6

Small-scale

0.571

High

865198

NOP56
Nucleolar protein 56

2

2

Small-scale

0.571

High

763588

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

Small-scale

0.559

High

852574

ROK1
ATP-dependent RNA helicase ROK1

2

0

Small-scale

0.559

High

865150

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

865151

NAT10
RNA cytidine acetyltransferase

2

0

High-throughput

0.559

High

865177

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

2

0

Small-scale

0.559

High

865174

MRD1
Multiple RNA-binding domain-containing protein 1

1

1

Small-scale

0.536

High

503127

RS22A
Small ribosomal subunit protein uS8A

2

2

High-throughput

0.533

High

627856

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

5

High-throughput

0.515

High

865196

UTP23
rRNA-processing protein UTP23

1

1

Small-scale

0.515

High

722060

XPO1
Exportin-1

1

0

High-throughput

0.513

High

745598

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.493

High

805981

RT107
Regulator of Ty1 transposition protein 107

1

0

Small-scale

0.486

High

749690

TYE7
Transcription factor TYE7

1

1

High-throughput

0.481

High

865181

HDA2
HDA1 complex subunit 2

1

1

High-throughput

0.481

High

792857

ANM1
Protein arginine N-methyltransferase 1

1

0

Small-scale

0.480

High

435200

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

513095

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.479

High

632699

DBP4
ATP-dependent RNA helicase HCA4

1

3

Small-scale

0.479

High

679835

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

707517

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

735054

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

753456

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

782079

RL1D1
Ribosome biogenesis protein UTP30

1

3

High-throughput

0.479

High

792126

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

802758

RRP3
ATP-dependent rRNA helicase RRP3

1

3

Small-scale

0.479

High

803884

CIC1
Proteasome-interacting protein CIC1

1

3

High-throughput

0.479

High

804724

RRP4
Exosome complex component RRP4

1

1

High-throughput

0.479

High

811998

RS14B
Small ribosomal subunit protein uS11B

1

1

Small-scale

0.479

High

824740

MLP2
Protein MLP2

1

1

High-throughput

0.479

High

826028

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.479

High

826627

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

863110

RRP41
Exosome complex component SKI6

1

2

High-throughput

0.479

High

864466

MTR4
ATP-dependent RNA helicase DOB1

1

2

High-throughput

0.479

High

865139

RS7B
Small ribosomal subunit protein eS7B

1

1

Small-scale

0.479

High

865145

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

865146

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

865152

NOP15
Ribosome biogenesis protein 15

1

3

High-throughput

0.479

High

865158

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

865171

RRP45
Exosome complex component RRP45

1

2

High-throughput

0.479

High

865176

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

865185

RRP44
Exosome complex exonuclease DIS3

1

1

High-throughput

0.479

High

865193

MAK21
Ribosome biogenesis protein MAK21

1

2

High-throughput

0.479

High

865195

RRP42
Exosome complex component RRP42

1

2

High-throughput

0.479

High

865197

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.479

High

597194

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.460

High

844470

GZF3
Protein GZF3

1

0

High-throughput

0.460

High

436455

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

514714

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

646461

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

647157

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

672911

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

673200

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

709853

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

804937

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

808284

RRP8
25S rRNA

1

0

High-throughput

0.458

High

808851

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

818317

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

825060

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

825618

AIR1
Protein AIR1

1

0

Small-scale

0.458

High

836184

DIM1
Dimethyladenosine transferase

1

0

Small-scale

0.458

High

864926

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

865138

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

865141

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

865142

TRF5
Poly(A) RNA polymerase protein 1

1

0

Small-scale

0.458

High

865143

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

865148

MPP6
M-phase phosphoprotein 6 homolog

1

0

High-throughput

0.458

High

865153

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

865165

BUD22
Bud site selection protein 22

1

0

High-throughput

0.458

High

865170

HRQ1
ATP-dependent helicase HRQ1

1

0

Small-scale

0.458

High

865178

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

865184

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

865186

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

865187

SGO1
Shugoshin

1

0

High-throughput

0.458

High

865190

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

865199

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

865201

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

865202

EFG1P
rRNA-processing protein EFG1

1

0

High-throughput

0.458

High

865205

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

816518

SNU13
13 kDa ribonucleoprotein-associated protein

1

2

Small-scale

0.445

High

819146

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

735644

SMY1
Kinesin-related protein SMY1

1

1

High-throughput

0.439

High

753116

NIP80
Protein NIP100

1

1

High-throughput

0.439

High

383780

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

433724

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

504296

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

579663

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

752452

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

812449

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

865155

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

865203

RS22B
Small ribosomal subunit protein uS8B

1

2

High-throughput

0.437

High

503508

RS28B
Small ribosomal subunit protein eS28B

1

0

Small-scale

0.426

High

746293

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.269

Low

737003

CDC3
Cell division control protein 3

1

0

High-throughput

0.251

Low

858507

STB2
Protein STB2

1

0

High-throughput

0.251

Low

804854

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

865160

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

865164

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

865167

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

810843

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low

826447

DJP1
DnaJ-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025