HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: ITM2B (Q9Y287)
Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]
Gene: ITM2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	16027166, 34446781, 32814053
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 266
+	Mm
		292577 A4_MOUSE (1-770): 0: 1016: 96.62		ITM2B_MOUSE (1-266): 3.23e-150: 421: 95.49
+	Hs
		212280 A4_HUMAN (19-770): 0: 999: 100.00		ITM2A_HUMAN (1-265): 3.5e-122: 350: 40.82
+	Hs
		395856 A4_HUMAN (19-770): 0: 999: 100.00		ITM2C_HUMAN (1-265): 2.84e-120: 345: 43.12
+	Hs
		987563 APLP2_HUMAN (3-769): 0: 858: 49.17		ITM2B_HUMAN (1-266): 1.45e-148: 417: 100.00