Protein: TF2H2
General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit)

Gene: TF2H2, GTF2H2
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q13888

Gene Ontology (top 5):
GO:0000438 - core TFIIH complex portion of holo TFIIH complex
GO:0000439 - transcription factor TFIIH core complex
GO:0002031 - G protein-coupled receptor internalization
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622806

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

13

2

Small-scale

0.980

High

1118806

TF2H3
General transcription factor IIH subunit 3

9

3

Small-scale

0.975

High

744659

TF2H1
General transcription factor IIH subunit 1

10

2

Small-scale

0.972

High

611667

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

7

4

Small-scale

0.961

High

1118815

TF2H5
General transcription factor IIH subunit 5

8

1

Small-scale

0.753

High

897266

CDK7
Cyclin-dependent kinase 7

11

2

Small-scale

0.753

High

1118821

TF2H4
General transcription factor IIH subunit 4

7

3

Small-scale

0.743

High

908745

MAT1
CDK-activating kinase assembly factor MAT1

3

2

Small-scale

0.660

High

908699

CCNH
Cyclin-H

3

1

Small-scale

0.633

High

704744

ERCC5
DNA excision repair protein ERCC-5

2

1

Small-scale

0.611

High

1118816

RN135
E3 ubiquitin-protein ligase RNF135

2

0

High-throughput

0.602

High

1118835

ZN232
Zinc finger protein 232

2

0

High-throughput

0.602

High

520028

ANDR
Androgen receptor

2

3

Small-scale

0.595

High

1118836

LHX6
LIM/homeobox protein Lhx6

2

0

High-throughput

0.585

High

1118814

T2H2L
General transcription factor IIH subunit 2-like protein

2

3

High-throughput

0.584

High

1098345

ERCC8
DNA excision repair protein ERCC-8

1

1

Small-scale

0.578

High

241638

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1118813

SWAP1
ATPase SWSAP1

1

0

High-throughput

0.513

High

1118826

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1118833

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.513

High

708896

T2EA
General transcription factor IIE subunit 1

1

1

Small-scale

0.501

High

596094

H12
Histone H1.2

1

0

High-throughput

0.493

High

137537

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

4

High-throughput

0.481

High

1118823

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

1

High-throughput

0.481

High

1118828

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

1118832

DNM3L
DNA

1

0

Small-scale

0.480

High

132474

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.479

High

172798

XPO1
Exportin-1

1

3

High-throughput

0.479

High

396079

ESR1
Estrogen receptor

1

3

High-throughput

0.479

High

879071

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

1106328

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

1118805

TF2H2
General transcription factor IIH subunit 2

1

3

High-throughput

0.479

High

1118808

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1118809

CDK10
Cyclin-dependent kinase 10

1

2

High-throughput

0.479

High

1118820

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1118827

CLK4
Dual specificity protein kinase CLK4

1

1

High-throughput

0.479

High

1118829

PRD11
PR domain-containing protein 11

1

1

High-throughput

0.479

High

1118831

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.460

High

247891

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

371985

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

770385

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.458

High

830707

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

938096

ANM2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.458

High

958638

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.458

High

1024566

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1107703

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1113064

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1118807

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1118818

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1118822

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1118824

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1118830

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1118817

FA43A
Protein FAM43A

1

1

High-throughput

0.439

High

1118810

CCD40
Coiled-coil domain-containing protein 40

1

1

High-throughput

0.437

High

1118819

DLRB2
Dynein light chain roadblock-type 2

1

1

High-throughput

0.437

High

1118825

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1118811

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1064985

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

289351

CTAG2
Cancer/testis antigen 2

1

0

High-throughput

0.279

Low

608263

EGLN
Endoglin

1

0

High-throughput

0.279

Low

718397

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

345790

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

710233

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.249

Low

838936

RHG25
Rho GTPase-activating protein 25

1

0

High-throughput

0.249

Low

1118812

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1118834

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1118837

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025