HitPredict - High confidence protein-protein interactions

Interactor 1: IL5 (P05113)
Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)
Gene: IL5

Interactor 2: IL5 (P05113)
Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)
Gene: IL5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.90	0.823

Property	Details
Experiments	7534492, 8483502, 2361960
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, reverse phase chromatography
Interaction Type	direct interaction, physical association, association, disulfide bond

Property	Details
Interacting Pfam domains	IL5~IL5
Common GO terms	GO:0002639 - positive regulation of immunoglobulin production GO:0005125 - cytokine activity GO:0005137 - interleukin-5 receptor binding GO:0005576 - extracellular region GO:0005615 - extracellular space and 10 others more... GO:0006954 - inflammatory response GO:0006955 - immune response GO:0008083 - growth factor activity GO:0030890 - positive regulation of B cell proliferation GO:0038043 - interleukin-5-mediated signaling pathway GO:0045645 - positive regulation of eosinophil differentiation GO:0045893 - positive regulation of DNA-templated transcription GO:0046427 - positive regulation of receptor signaling pathway via JAK-STAT GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation GO:0071803 - positive regulation of podosome assembly
Homologous interactions	0

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Last updated: 15 Jul 2024