HitPredict

Interactor 1: FGF1 (P05230)
Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1)
Gene: FGF1

Interactor 2: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 18199118, 10748122, 8692946, 28769084, 1709094, 18261743, 1697263, 8756477, 1383494, 1309595, 8576175, 22955284, 11714710, 8321198, 9624181, 11030354, 33961781, 1722683, 10830168, 7730326 and 3 others

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Identification Methods unspecified method, pull down, x-ray crystallography, affinity chromatography technology, cross-linking study, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FGF~I-set
Common GO terms GO:0001525 - angiogenesis
GO:0001759 - organ induction
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005829 - cytosol
and 4 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024