Protein: KLK6
Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme)

Gene: KLK6
Organism: Homo sapiens
Interactions: 192
UniProt ID: Q92876

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

422771

A4
Amyloid-beta precursor protein

2

14

Small-scale

0.759

High

240200

KLK8
Kallikrein-8

1

13

High-throughput

0.665

High

1306937

TMPS6
Transmembrane protease serine 6

1

18

High-throughput

0.665

High

1369675

LOXL4
Lysyl oxidase homolog 4

1

10

High-throughput

0.665

High

1369718

CDYL
Chromodomain Y-like protein

2

8

High-throughput

0.621

High

791600

SYUA
Alpha-synuclein

2

3

Small-scale

0.611

High

1369680

STAC
SH3 and cysteine-rich domain-containing protein

1

3

High-throughput

0.594

High

387740

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

5

Small-scale

0.575

High

387865

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

5

Small-scale

0.575

High

1369666

KLK6
Kallikrein-6

1

12

Small-scale

0.575

High

1241920

FBX42
F-box only protein 42

2

3

High-throughput

0.574

High

840859

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

0

High-throughput

0.556

High

1040069

PAX2
Paired box protein Pax-2

1

1

High-throughput

0.541

High

1369683

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.541

High

552338

ADT3
ADP/ATP translocase 3

1

17

High-throughput

0.536

High

733409

CCR1
C-C chemokine receptor type 1

1

6

High-throughput

0.536

High

997066

TBA4A
Tubulin alpha-4A chain

1

18

High-throughput

0.536

High

1055626

GABPA
GA-binding protein alpha chain

1

5

High-throughput

0.536

High

1108645

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.536

High

1306979

CERS3
Ceramide synthase 3

1

4

High-throughput

0.536

High

1369672

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.536

High

1369678

STRBP
Spermatid perinuclear RNA-binding protein

1

1

High-throughput

0.536

High

1369684

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

7

High-throughput

0.536

High

1369691

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.536

High

1369714

PHF11
PHD finger protein 11

1

3

High-throughput

0.536

High

1369722

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.536

High

1369724

RN115
E3 ubiquitin-protein ligase RNF115

1

2

High-throughput

0.536

High

1294947

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.518

High

2019

A0A0A0MR05
Target of rapamycin complex subunit LST8

1

1

High-throughput

0.515

High

132202

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.515

High

164617

TNPO2
Transportin-2

1

4

High-throughput

0.515

High

180004

BET1
BET1 homolog

1

1

High-throughput

0.515

High

250741

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.515

High

252618

TSN2
Tetraspanin-2

1

2

High-throughput

0.515

High

347853

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.515

High

447278

NPM
Nucleophosmin

1

1

High-throughput

0.515

High

447822

TPM3
Tropomyosin alpha-3 chain

1

3

High-throughput

0.515

High

479610

DOPO
Dopamine beta-hydroxylase

1

2

High-throughput

0.515

High

485810

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

3

High-throughput

0.515

High

590470

GATA1
Erythroid transcription factor

1

1

High-throughput

0.515

High

635415

CO9A1

1

3

High-throughput

0.515

High

881576

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.515

High

904045

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.515

High

913971

RBM5
RNA-binding protein 5

1

1

High-throughput

0.515

High

914159

HXK3
Hexokinase-3

1

2

High-throughput

0.515

High

944715

KLF3
Krueppel-like factor 3

1

3

High-throughput

0.515

High

964696

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.515

High

983401

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

4

High-throughput

0.515

High

1086067

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.515

High

1095916

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.515

High

1103924

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

1

High-throughput

0.515

High

1119766

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

3

High-throughput

0.515

High

1125317

FASTK
Fas-activated serine/threonine kinase

1

6

High-throughput

0.515

High

1127820

KRT81
Keratin, type II cuticular Hb1

1

1

High-throughput

0.515

High

1133136

LASP1
LIM and SH3 domain protein 1

1

4

High-throughput

0.515

High

1153376

MK11
Mitogen-activated protein kinase 11

1

2

High-throughput

0.515

High

1158645

PCSK7
Proprotein convertase subtilisin/kexin type 7

1

7

High-throughput

0.515

High

1198963

ACSM3
Acyl-coenzyme A synthetase ACSM3, mitochondrial

1

2

High-throughput

0.515

High

1219418

TUT7
Terminal uridylyltransferase 7

1

1

High-throughput

0.515

High

1239368

ESRP1
Epithelial splicing regulatory protein 1

1

5

High-throughput

0.515

High

1271302

5MP2
eIF5-mimic protein 2

1

1

High-throughput

0.515

High

1272370

FA2H
Fatty acid 2-hydroxylase

1

5

High-throughput

0.515

High

1272767

G2E3
G2/M phase-specific E3 ubiquitin-protein ligase

1

3

High-throughput

0.515

High

1280838

Q7Z783
Protein sprouty homolog 2

1

1

High-throughput

0.515

High

1286585

SDCG8
Serologically defined colon cancer antigen 8

1

4

High-throughput

0.515

High

1288410

TSN33
Tetraspanin-33

1

1

High-throughput

0.515

High

1307761

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

High-throughput

0.515

High

1307866

TMTC1
Protein O-mannosyl-transferase TMTC1

1

11

High-throughput

0.515

High

1329636

EFNMT
eEF1A lysine and N-terminal methyltransferase

1

1

High-throughput

0.515

High

1365634

LAR4B
La-related protein 4B

1

2

High-throughput

0.515

High

1369668

RNF34
E3 ubiquitin-protein ligase RNF34

1

3

High-throughput

0.515

High

1369681

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

5

High-throughput

0.515

High

1369682

SMAD5
Mothers against decapentaplegic homolog 5

1

1

High-throughput

0.515

High

1369685

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

1

High-throughput

0.515

High

1369690

RBM4
RNA-binding protein 4

1

2

High-throughput

0.515

High

1369693

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

5

High-throughput

0.515

High

1369694

SPY4
Protein sprouty homolog 4

1

1

High-throughput

0.515

High

1369699

CARD9
Caspase recruitment domain-containing protein 9

1

1

High-throughput

0.515

High

1369701

TLE6
Transducin-like enhancer protein 6

1

6

High-throughput

0.515

High

1369703

XPO5
Exportin-5

1

5

High-throughput

0.515

High

1369708

RFOX1
RNA binding protein fox-1 homolog 1

1

2

High-throughput

0.515

High

1369709

TSAP1
tRNA selenocysteine 1-associated protein 1

1

1

High-throughput

0.515

High

1369710

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

1

2

High-throughput

0.515

High

1369712

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.515

High

1369713

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

5

High-throughput

0.515

High

1369717

BAIP2
BAR/IMD domain-containing adapter protein 2

1

2

High-throughput

0.515

High

1369720

COF2
Cofilin-2

1

2

High-throughput

0.515

High

1369723

KLH20
Kelch-like protein 20

1

1

High-throughput

0.515

High

340768

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

0

High-throughput

0.513

High

750512

LSP1
Lymphocyte-specific protein 1

1

1

High-throughput

0.494

High

216502

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.493

High

621928

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.493

High

636747

PTN
Pleiotrophin

1

0

High-throughput

0.493

High

665279

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.493

High

876272

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

0

High-throughput

0.493

High

923474

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

1

0

High-throughput

0.493

High

960511

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.493

High

965134

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.493

High

991658

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.493

High

997913

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.493

High

1032028

TFAP4
Transcription factor AP-4

1

0

High-throughput

0.493

High

1081427

INCA1
Protein INCA1

1

0

High-throughput

0.493

High

1103641

PHLP
Phosducin-like protein

1

0

High-throughput

0.493

High

1209026

ERIC3
Glutamate-rich protein 3

1

0

High-throughput

0.493

High

1211631

SPT46
Spermatogenesis-associated protein 46

1

0

High-throughput

0.493

High

1239775

FAP20
Fanconi anemia core complex-associated protein 20

1

0

High-throughput

0.493

High

1334438

ACBD4
Acyl-CoA-binding domain-containing protein 4

1

0

High-throughput

0.493

High

1337113

CHDH
Choline dehydrogenase, mitochondrial

1

0

High-throughput

0.493

High

1348738

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.493

High

1358423

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

0

High-throughput

0.493

High

1358922

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.493

High

1369670

TET5B
Terminal nucleotidyltransferase 5B

1

0

High-throughput

0.493

High

1369671

ALKB8
tRNA

1

0

High-throughput

0.493

High

1369687

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.493

High

1369688

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.493

High

1369692

BEX2
Protein BEX2

1

0

High-throughput

0.493

High

1369695

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.493

High

1369696

TWSG1
Twisted gastrulation protein homolog 1

1

0

High-throughput

0.493

High

1369697

CK054
Ester hydrolase C11orf54

1

0

High-throughput

0.493

High

1369698

RN208
RING finger protein 208

1

0

High-throughput

0.493

High

1369707

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.493

High

1369715

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.493

High

1369719

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

0

High-throughput

0.493

High

1369721

INVS
Inversin

1

0

High-throughput

0.493

High

1369725

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

0

High-throughput

0.493

High

325343

OR2A4
Olfactory receptor 2A4

1

4

High-throughput

0.489

High

1181335

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

1218736

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

1315971

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

1333754

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.489

High

1369669

PIGT
GPI-anchor transamidase component PIGT

1

4

High-throughput

0.489

High

1369705

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

1

High-throughput

0.489

High

1358077

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

275816

CAD16
Cadherin-16

1

19

High-throughput

0.470

High

286696

STX11
Syntaxin-11

1

1

High-throughput

0.470

High

320919

TOX
Thymocyte selection-associated high mobility group box protein TOX

1

4

High-throughput

0.470

High

475650

K1C19
Keratin, type I cytoskeletal 19

1

4

High-throughput

0.470

High

536281

PPAL
Lysosomal acid phosphatase

1

3

High-throughput

0.470

High

596839

EPB42
Protein 4.2

1

3

High-throughput

0.470

High

660697

IF4B
Eukaryotic translation initiation factor 4B

1

1

High-throughput

0.470

High

731814

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

4

High-throughput

0.470

High

867713

RGR
RPE-retinal G protein-coupled receptor

1

6

High-throughput

0.470

High

1131586

MFS10
Major facilitator superfamily domain-containing protein 10

1

1

High-throughput

0.470

High

1204733

ARMX4
Armadillo repeat-containing X-linked protein 4

1

6

High-throughput

0.470

High

1231704

LEG9C
Galectin-9C

1

1

High-throughput

0.470

High

1253322

D19L3
Protein C-mannosyl-transferase DPY19L3

1

1

High-throughput

0.470

High

1288033

PRP39
Pre-mRNA-processing factor 39

1

6

High-throughput

0.470

High

1292829

Q86WV2
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.470

High

1322334

ZN444
Zinc finger protein 444

1

1

High-throughput

0.470

High

1369676

TNIP3
TNFAIP3-interacting protein 3

1

2

High-throughput

0.470

High

1369677

PRAM
PML-RARA-regulated adapter molecule 1

1

2

High-throughput

0.470

High

1369686

CNPY3
Protein canopy homolog 3

1

1

High-throughput

0.470

High

1369689

SPON2
Spondin-2

1

5

High-throughput

0.470

High

1369702

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

3

High-throughput

0.470

High

1369706

SEM4G
Semaphorin-4G

1

12

High-throughput

0.470

High

1369711

PDXL2
Podocalyxin-like protein 2

1

1

High-throughput

0.470

High

261239

NSMA
Sphingomyelin phosphodiesterase 2

1

5

High-throughput

0.445

High

384319

CO4A1

1

5

Small-scale

0.445

High

388656

C1QA
Complement C1q subcomponent subunit A

1

4

High-throughput

0.445

High

388790

C1QC
Complement C1q subcomponent subunit C

1

7

High-throughput

0.445

High

471602

CO4A2

1

5

Small-scale

0.445

High

712119

CO4A5

1

5

Small-scale

0.445

High

866440

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

1

1

Small-scale

0.445

High

920926

CO4A4

1

5

Small-scale

0.445

High

1033919

CO4A3
Collagen alpha-3(IV) chain

1

5

Small-scale

0.445

High

1120069

CO4A6

1

5

Small-scale

0.445

High

1369679

MYCBP
c-Myc-binding protein

1

2

High-throughput

0.445

High

1369716

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

2

High-throughput

0.407

High

73680

B2RAF7
HCG1818547

1

0

High-throughput

0.268

Low

284489

CLD11
Claudin-11

1

0

High-throughput

0.268

Low

333800

O95332
LOC57228 protein

1

0

High-throughput

0.268

Low

692243

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.268

Low

1186898

KR195
Keratin-associated protein 19-5

1

0

High-throughput

0.268

Low

1187899

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.268

Low

1193232

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.268

Low

1196856

Q4VB01
HOXB1 protein

1

0

High-throughput

0.268

Low

1242380

PBIR3
PABIR family member 1

1

0

High-throughput

0.268

Low

1251546

THADA
tRNA

1

0

High-throughput

0.268

Low

1251836

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

1273262

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.268

Low

1294037

CTSRD
Cation channel sperm-associated auxiliary subunit delta

1

0

High-throughput

0.268

Low

1307083

KRA81
Keratin-associated protein 8-1

1

0

High-throughput

0.268

Low

1314595

IHO1
Interactor of HORMAD1 protein 1

1

0

High-throughput

0.268

Low

1351632

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.268

Low

1352079

LMX1A
LIM homeobox transcription factor 1-alpha

1

0

High-throughput

0.268

Low

1361057

ASB13
Ankyrin repeat and SOCS box protein 13

1

0

High-throughput

0.268

Low

1369667

NGN1
Neurogenin-1

1

0

High-throughput

0.268

Low

1369673

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.268

Low

1369674

Q96EJ4
PLAC8 protein

1

0

High-throughput

0.268

Low

1369700

S26A1
Sulfate anion transporter 1

1

0

High-throughput

0.268

Low

1369704

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025