HitPredict

Interactor 1: FGF1 (P05230)
Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1)
Gene: FGF1

Interactor 2: PGBM (P98160)
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]
Gene: HSPG2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 24509440
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, enzyme linked immunosorbent assay
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FGF~I-set, FGF~Ig_3
Common GO terms	GO:0001525 - angiogenesis GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0030154 - cell differentiation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 155 Hs			1 4391
+	Hs
		601115 FGF7_HUMAN (13-153): 1.87e-65: 199: 35.66		PGBM_HUMAN (22-4391): 0: 2697: 100.00
+	Hs
		447034 FGF2_HUMAN (1-154): 7.49e-63: 196: 54.14		PGBM_HUMAN (22-4391): 0: 2697: 100.00
+	Hs
		441822 FGF4_HUMAN (15-151): 3.89e-55: 174: 35.51		PGBM_HUMAN (22-4391): 0: 2697: 100.00
+	Hs
		399150 FGF1_HUMAN (1-155): 2.95e-74: 220: 100.00		EGFLA_HUMAN (4143-4391): 4.03e-14: 81.6: 29.92
+	Hs
		129653 FGF4_HUMAN (15-151): 3.89e-55: 174: 35.51		AGRIN_HUMAN (4151-4365): 7.12e-18: 94.4: 32.14
+	Hs
		172633 FGF4_HUMAN (15-151): 3.89e-55: 174: 35.51		LAMA5_HUMAN (725-800): 4.51e-10: 68.7: 29.11
+	Hs
		441810 FGF4_HUMAN (15-151): 3.89e-55: 174: 35.51		LAMA1_HUMAN (3800-4223): 5.66e-09: 65: 12.14