Interactor 1: EDN1 (P05305)
Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1]
Gene: EDN1

Interactor 2: EDNRA (P25101)
Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR)
Gene: EDNRA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 7509919, 23597562
Identification Methods pull down, scintillation proximity assay
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~Endothelin
Common GO terms GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001701 - in utero embryonic development
GO:0001975 - response to amphetamine
GO:0003094 - glomerular filtration
GO:0003253 - cardiac neural crest cell migration involved in outflow tract morphogenesis
and 34 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 212
Hs

1 427
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024