HitPredict

Interactor 1: RLA2 (P05319)
Large ribosomal subunit protein P2A (P2A) (60S acidic ribosomal protein P2-alpha) (A2) (L12eIB) (L44) (YP2alpha)
Gene: RPP2A

Interactor 2: RLA3 (P10622)
Large ribosomal subunit protein P1B (P1B) (60S acidic ribosomal protein P1-beta) (Ax) (L12eIIB) (L44') (YP1beta)
Gene: RPP1B

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	14617190, 37968396, 20225338, 12410829
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ribosomal_60s~Ribosomal_60s
Common GO terms	GO:0002181 - cytoplasmic translation GO:0003735 - structural constituent of ribosome GO:0022625 - cytosolic large ribosomal subunit GO:0030295 - protein kinase activator activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 106 Sc			1 106
+	At
		1227633 RLA24_ARATH (1-106): 2.05e-24: 90.8: 39.64		RLA11_ARATH (1-106): 2.21e-31: 108: 36.70
+	Ce
		136456 RLA2_CAEEL (1-106): 2.51e-26: 95.4: 48.60		RLA1_CAEEL (3-106): 2.64e-28: 100: 43.40
+	Hs
		400202 RLA2_HUMAN (1-106): 4.16e-24: 90: 45.22		RLA1_HUMAN (1-106): 3.72e-30: 105: 35.14
+	Dm
		401205 RLA2_DROME (1-64): 4.9e-21: 82.3: 44.62		RLA1_DROME (2-106): 6.25e-33: 112: 38.89
+	Ca
		1124293 Q5ANH5_CANAL (1-106): 1.08e-25: 93.8: 64.87		RLA1_CANAL (2-106): 4.55e-24: 89.8: 57.14
+	Sc
		357410 RLA4_YEAST (1-106): 4.76e-23: 87.3: 61.82		RLA1_YEAST (2-106): 1.51e-26: 95.9: 55.24
+	Sc
		357442 RLA4_YEAST (1-106): 4.76e-23: 87.3: 61.82		RLA3_YEAST (1-106): 1.08e-25: 94: 100.00
+	Sc
		399691 RLA2_YEAST (14-106): 5.18e-19: 76.9: 100.00		RLA1_YEAST (2-106): 1.51e-26: 95.9: 55.24